Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

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Change in retinal structural anatomy during the preclinical stage of Alzheimer's disease
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring - Tập 10 - Trang 196-209 - 2018
Cláudia Y. Santos, Lenworth N. Johnson, Stuart E. Sinoff, Elena K. Festa, William C. Heindel, Peter J. Snyder
AbstractIntroductionWe conducted a 27‐month longitudinal study of mid‐life adults with preclinical Alzheimer's disease (AD), using spectral domain optical coherence tomography to compare changes in volume and thickness in all retinal neuronal layers to those of age‐matched healthy control subjects.MethodsFifty‐six older adults (mean age = 65.36 years) with multiple risk factors for AD completed sp... hiện toàn bộ
Advances in Alzheimer's imaging are changing the experience of Alzheimer's disease
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring - Tập 10 - Trang 285-300 - 2018
Shana D. Stites, Richard Milne, Jason Karlawish
AbstractNeuroimaging is advancing a new definition of Alzheimer's disease (AD). Using imaging biomarkers, clinicians may begin to diagnose the disease by identifying pathology and neurodegeneration in either cognitively impaired or unimpaired adults. This “biomarker‐based” diagnosis may allow clinicians novel opportunities to use interventions that either delay the onset or slow the progression of... hiện toàn bộ
Amyloid burden, cortical thickness, and cognitive function in the Wisconsin Registry for Alzheimer's Prevention
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring - Tập 1 - Trang 160-169 - 2015
Benjamin M. Doherty, Stephanie A. Schultz, Jennifer M. Oh, Rebecca L. Koscik, N. Maritza Dowling, Todd E. Barnhart, Dhanabalan Murali, Catherine L. Gallagher, Cynthia M. Carlsson, Barbara B. Bendlin, Asenath LaRue, Bruce P. Hermann, Howard A. Rowley, Sanjay Asthana, Mark A. Sager, Brad T. Christian, Sterling C. Johnson, Ozioma C. Okonkwo
AbstractThere is a growing interest in understanding how amyloid β (Aβ) accumulation in preclinical Alzheimer's disease relates to brain morphometric measures and cognition. Existing investigations in this area have been primarily conducted in older cognitively normal (CN) individuals. Therefore, not much is known about the associations between Aβ burden, cortical thickness, and cognition in midli... hiện toàn bộ
Relationship between the Activities of Daily Living Questionnaire and the Montreal Cognitive Assessment
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring - Tập 4 - Trang 43-46 - 2016
January Durant, Gabriel C. Leger, Sarah J. Banks, Justin B. Miller
AbstractIntroductionThe Activities of Daily Living Questionnaire (ADL‐Q) is an informant report questionnaire assessing functional impairment in daily living skills. Previous research has demonstrated correlations between ADL‐Q and cognitive screening measures among patients with dementia. This study examined the relationship between ADL‐Q and the Montreal Cognitive Assessment (MoCA), a brief cogn... hiện toàn bộ
Factors affecting the harmonization of disease‐related metabolic brain pattern expression quantification in [18F]FDG‐PET (PETMETPAT)
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring - Tập 11 - Trang 472-482 - 2019
Rosalie V. Kogan, Bas A. de Jong, Remco J. Renken, Sanne K. Meles, Paul J.H. van Snick, Sandeep Golla, Sjoerd Rijnsdorp, Daniela Perani, Klaus L. Leenders, Ronald Boellaard
AbstractIntroductionThe implementation of spatial‐covariance [18F]fluorodeoxyglucose positron emission tomography–based disease‐related metabolic brain patterns as biomarkers has been hampered by intercenter imaging differences. Within the scope of the JPND‐PETMETPAT working group, we illustrate the impact of these differences on Parkinson's disease–related pattern (PDRP) expression scores.Methods... hiện toàn bộ
Reduced future‐oriented decision making in individuals with subjective cognitive decline: A functional MRI study
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring - Tập 6 - Trang 222-231 - 2017
Xiaochen Hu, Franziska Uhle, Klaus Fliessbach, Michael Wagner, Ying Han, Bernd Weber, Frank Jessen
AbstractIntroductionSubjective cognitive decline (SCD) refers to an at‐risk state of Alzheimer's disease and subtle cognitive deficits that have been observed in this condition. Currently, it is unknown whether complex cognitive processes relevant to everyday life, such as future‐oriented choice behavior, are also altered in SCD.MethodsTwenty SCD participants and 24 control (CO) participants took ... hiện toàn bộ
Tau positron emission tomography imaging in tauopathies: The added hurdle of off‐target binding
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring - Tập 10 - Trang 232-236 - 2018
Laetitia Lemoine, Antoine Leuzy, Konstantinos Chiotis, Elena Rodriguez-Vieitez, Agneta Nordberg
AbstractLigands targeting tau for use with positron emission tomography have rapidly been developed during the past several years, enabling the in vivo study of tau pathology in patients with Alzheimer's disease and related non‐Alzheimer's disease tauopathies. Several candidate compounds have been developed, showing good in vitro characteristics with respect to their ability to bind tau deposits; ... hiện toàn bộ
Sensitivity of composite scores to amyloid burden in preclinical Alzheimer's disease: Introducing the Z‐scores of Attention, Verbal fluency, and Episodic memory for Nondemented older adults composite score
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring - Tập 2 - Trang 19-26 - 2016
Yen Ying Lim, Peter J. Snyder, Robert H. Pietrzak, Albulene Ukiqi, Victor L. Villemagne, David Ames, Olivier Salvado, Pierrick Bourgeat, Ralph N. Martins, Colin L. Masters, Christopher C. Rowe, Paul Maruff
AbstractIntroductionCognitive composite scores developed for preclinical Alzheimer's disease (AD) often consist of multiple cognitive domains as they may provide greater sensitivity to detect β‐amyloid (Aβ)–related cognitive decline than episodic memory (EM) composite scores alone. However, this has never been empirically tested. We compared the rate of cognitive decline associated with high Aβ (A... hiện toàn bộ
Cerebrospinal fluid biomarkers for Alzheimer's disease in Down syndrome
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring - Tập 8 - Trang 1-10 - 2017
Alain D. Dekker, Juan Fortea, Rafael Blesa, Peter P. De Deyn
AbstractDown syndrome (DS), present in nearly six million people, is associated with an extremely high risk to develop Alzheimer's disease (AD). Amyloid‐β and tau pathology are omnipresent from age 40 years onward, but clinical symptoms do not appear in all DS individuals. Dementia diagnostics is complex in this population, illustrating the great need for predictive biomarkers. Although blood biom... hiện toàn bộ
Qualitative and quantitative assessment of self‐reported cognitive difficulties in nondemented elders: Association with medical help seeking, cognitive deficits, and β‐amyloid imaging
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring - Tập 5 - Trang 23-34 - 2016
Renaud La Joie, Audrey Perrotin, Stéphanie Egret, Florence Pasquier, Clémence Tomadesso, Florence Mézenge, Béatrice Desgranges, Vincent de La Sayette, Gaël Chételat
AbstractIntroductionSubjective cognitive decline (SCD) could help identify early stages of Alzheimer's disease. However, SCD is multidetermined and protean, and the type of cognitive complaint associated with preclinical Alzheimer's disease needs refinement.MethodsA total of 185 nondemented elders recruited from either the community or from a memory clinic filled a questionnaire. We searched for i... hiện toàn bộ
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