Qualitative and quantitative assessment of self‐reported cognitive difficulties in nondemented elders: Association with medical help seeking, cognitive deficits, and β‐amyloid imaging

Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring - Tập 5 - Trang 23-34 - 2016
Renaud La Joie1,2,3,4, Audrey Perrotin1,2,3,4, Stéphanie Egret1,2,3,4, Florence Pasquier5,6, Clémence Tomadesso1,2,3,4, Florence Mézenge1,2,3,4, Béatrice Desgranges1,2,3,4, Vincent de La Sayette1,2,3,7, Gaël Chételat1,2,3,4
1INSERM, U1077, Caen, France
2Université de Caen Normandie, UMR-S1077, Caen, France
3Ecole Pratique des Hautes Etudes, UMR-S1077, Caen, France
4CHU de Caen, U1077, Caen, France
5Department of Neurology, Memory Research and Resources Clinic, University Hospital of Lille, Lille, France
6Université de Lille Nord de France, Lille, France
7CHU de Caen, Service de Neurologie, Caen, France

Tóm tắt

AbstractIntroductionSubjective cognitive decline (SCD) could help identify early stages of Alzheimer's disease. However, SCD is multidetermined and protean, and the type of cognitive complaint associated with preclinical Alzheimer's disease needs refinement.MethodsA total of 185 nondemented elders recruited from either the community or from a memory clinic filled a questionnaire. We searched for item responses associated with medical help seeking, cognitive deficits, and β‐amyloidosis.ResultsCompared with community‐recruited control subjects (n = 74), help‐seeking patients reported a stronger multidomain SCD that was mostly unrelated to the presence of detectable cognitive deficits. Only a few items, notably assessing temporal disorientation, distinguished help‐seeking patients with (n = 78) or without (n = 33) memory deficits. Associations between SCD and β‐amyloidosis were not restricted to the memory domain and varied across clinical stages.DiscussionDetailed evaluation of SCD could provide accessible indication of the presence of β‐amyloid or cognitive deficits, which might prove useful for early diagnosis and clinical trial enrichment strategies.

Tài liệu tham khảo

10.1176/ajp.139.9.1136 10.1001/archneur.1990.00530110043015 10.1001/archneur.56.3.303 10.1016/j.jalz.2011.03.003 10.1016/j.jalz.2016.02.002 10.1111/acps.12336 10.3233/JAD-150202 10.1016/j.jalz.2016.08.011 10.1016/j.jagp.2015.01.008 10.1016/j.neuropsychologia.2012.08.011 10.1001/archneurol.2011.666 Mielke M.M., 2012, Indicators of amyloid burden in a population‐based study of cognitively normal elderly, Neurology, 9, 1570, 10.1212/WNL.0b013e31826e2696 10.1007/s12031-016-0810-z 10.1016/j.dadm.2016.07.002 10.1097/WAD.0000000000000144 10.1126/scitranslmed.3007941 10.1001/jama.2015.4668 10.1093/bmb/ldu029 10.1016/S0165-0327(01)00453-0 10.1016/j.jalz.2014.01.001 10.1016/j.jalz.2016.09.012 10.3233/JAD-150154 McNair D.M., 1983, Self‐assessment of cognitive deficits. Assessment in geriatric psychopharmacology 10.1002/ana.24462 10.3233/JAD-150087 10.1523/JNEUROSCI.0150-15.2015 10.1016/j.neuron.2014.01.026 10.1016/j.neuroimage.2011.11.036 10.1097/WAD.0b013e3181cfc78b 10.1080/01688639708403858 10.1002/gps.930080712 10.1093/brain/awv112 Winter J.C.F., 2010, Five‐point likert items: T test versus Mann‐Whitney‐Wilcoxon, Pract Assess Res Eval, 15, 1 Baglin J., 2014, Improving your exploratory factor analysis for ordinal data: a demonstration using FACTOR, Pract Assess Res Eval, 19, 1 10.1155/2012/725329 10.1017/S1041610212001846 10.1177/1533317514539032 10.1002/gps.4272 10.1017/S1041610213002263 10.1097/WAD.0b013e31816bbd27 10.1007/s13760-016-0604-7 10.1016/j.trci.2015.04.002 10.1007/s004019900166 10.1136/jnnp.64.4.552 10.1038/nrn3338 10.3233/JAD-160204 10.1016/j.neurobiolaging.2013.08.017 10.1017/S135561771400068X 10.2174/1567205011666141001120903 10.1016/j.dadm.2015.09.004 10.1097/WAD.0b013e3182420bdf
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Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

Tập 5

23-34

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