Reduced future‐oriented decision making in individuals with subjective cognitive decline: A functional MRI study

Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring - Tập 6 - Trang 222-231 - 2017
Xiaochen Hu1,2, Franziska Uhle1,3, Klaus Fliessbach2,3, Michael Wagner2,3, Ying Han4, Bernd Weber5,6, Frank Jessen1,3
1Department of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Cologne, Germany
2Department of Psychiatry and Psychotherapy, University Hospital of Bonn, Bonn, Germany
3German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany
4Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China
5Department of Epileptology, University Hospital of Bonn, Bonn, Germany
6Center for Economics and Neuroscience, University of Bonn, Bonn, Germany

Tóm tắt

AbstractIntroductionSubjective cognitive decline (SCD) refers to an at‐risk state of Alzheimer's disease and subtle cognitive deficits that have been observed in this condition. Currently, it is unknown whether complex cognitive processes relevant to everyday life, such as future‐oriented choice behavior, are also altered in SCD.MethodsTwenty SCD participants and 24 control (CO) participants took part in a functional magnetic resonance imaging task on intertemporal decisions, with and without simultaneous episodic future imagination.ResultsSCD participants showed reduced future‐oriented choices. Future imagination increased future‐oriented choices and was associated with increased brain activation in medial frontal polar cortex, right insular cortex, and anterior cingulate cortex in CO only, not SCD. In addition, more future‐oriented choices were associated with hippocampal activation during choice processing in CO only.DiscussionSubtle neuronal network disruptions in SCD may underlie their myopic future decisions and lack of modulation of choice behavior by episodic future imagination.

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Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

Tập 6

222-231

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