Amyloid burden, cortical thickness, and cognitive function in the Wisconsin Registry for Alzheimer's Prevention

Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring - Tập 1 - Trang 160-169 - 2015
Benjamin M. Doherty1,2, Stephanie A. Schultz1,2, Jennifer M. Oh1,2, Rebecca L. Koscik3, N. Maritza Dowling2,4, Todd E. Barnhart5, Dhanabalan Murali5, Catherine L. Gallagher1,2,6, Cynthia M. Carlsson1,2,3, Barbara B. Bendlin1,2,3, Asenath LaRue3, Bruce P. Hermann2,3,6, Howard A. Rowley2,7, Sanjay Asthana1,2,3, Mark A. Sager2,3, Brad T. Christian2,5, Sterling C. Johnson1,2,3, Ozioma C. Okonkwo1,2,3
1Geriatric Research Education and Clinical Center, William S. Middleton Memorial VA Hospital, Madison, WI, USA
2Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
3Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
4Department of Biostatistics & Medical Informatics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
5Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
6Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
7Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA

Tóm tắt

AbstractThere is a growing interest in understanding how amyloid β (Aβ) accumulation in preclinical Alzheimer's disease relates to brain morphometric measures and cognition. Existing investigations in this area have been primarily conducted in older cognitively normal (CN) individuals. Therefore, not much is known about the associations between Aβ burden, cortical thickness, and cognition in midlife. We examined this question in 109, CN, late to middle‐aged adults (mean age = 60.72 ± 5.65 years) from the Wisconsin Registry for Alzheimer's Prevention. They underwent Pittsburgh Compound B (PiB) and anatomical magnetic resonance (MR) imaging, and a comprehensive cognitive examination. Blinded visual rating of the PiB scans was used to classify the participants as Aβ+ or Aβ−. Cortical thickness measurements were derived from the MR images. The Aβ+ group exhibited significant thinning of the entorhinal cortex and accelerated age‐associated thinning of the parahippocampal gyrus compared with the Aβ− group. The Aβ+ group also had numerically lower, but nonsignificant, test scores on all cognitive measures, and significantly faster age‐associated cognitive decline on measures of Speed & Flexibility, Verbal Ability, and Visuospatial Ability. Our findings suggest that early Aβ aggregation is associated with deleterious changes in brain structure and cognitive function, even in midlife, and that the temporal lag between Aβ deposition and the inception of neurodegenerative/cognitive changes might be narrower than currently thought.

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Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

Tập 1

160-169

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