Application of advanced brain positron emission tomography–based molecular imaging for a biological framework in neurodegenerative proteinopathies

Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring - Tập 11 - Trang 327-332 - 2019
Daniela Perani1,2, Leonardo Iaccarino3,1, Andreas H. Jacobs4,5
1In Vivo Human Molecular and Structural Neuroimaging Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy
2Nuclear Medicine Unit, San Raffaele Hospital, Milan, Italy
3Vita-Salute San Raffaele University, Milan, Italy
4European Institute for Molecular Imaging, University of Münster, Münster, Germany
5Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, Germany

Tóm tắt

AbstractIntroductionA rapid transition from a clinical‐based classification to a pathology‐based classification of neurodegenerative conditions, largely promoted by the increasing availability of imaging biomarkers, is emerging. The Framework for Innovative Multi‐tracer molecular Brain Imaging, funded by the EU Joint Program ‐ Neurodegenerative Disease Research 2016 “Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration,” aimed at providing a roadmap for the applications of established and new molecular imaging techniques in dementia.MethodsWe consider current and future implications of adopting a pathology‐based framework for the use and development of positron emission tomography techniques.ResultsThis approach will enhance efforts to understand the multifactorial etiology of Alzheimer's disease and other dementias.DiscussionThe availability of pathology biomarkers will soon transform clinical and research practice. Crucially, a comprehensive understanding of strengths and caveats of these techniques will promote an informed use to take full advantage of these tools.

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Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

Tập 11

327-332

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