Physiology
SCIE-ISI SCOPUS (2004-2023)
1548-9213
1548-9221
Mỹ
Cơ quản chủ quản: AMER PHYSIOLOGICAL SOC , American Physiological Society
Lĩnh vực:
Physiology
Các bài báo tiêu biểu
Hydroxylation of HIF-1: Oxygen Sensing at the Molecular Level The ability to sense and respond to changes in oxygenation represents a fundamental property of all metazoan cells. The discovery of the transcription factor HIF-1 has led to the identification of protein hydroxylation as a mechanism by which changes in Po2 are transduced to effect changes in gene expression.
Tập 19 Số 4 - Trang 176-182 - 2004
Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1Metazoan organisms are dependent on a continuous supply of O2 for survival. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that regulates oxygen homeostasis and plays key roles in development, physiology, and disease. HIF-1 activity is induced in response to continuous hypoxia, intermittent hypoxia, growth factor stimulation, and Ca2+ s... ...
Tập 24 Số 2 - Trang 97-106 - 2009
Signaling in Muscle Atrophy and HypertrophyMuscle performance is influenced by turnover of contractile proteins. Production of new myofibrils and degradation of existing proteins is a delicate balance, which, depending on the condition, can promote muscle growth or loss. Protein synthesis and protein degradation are coordinately regulated by pathways that are influenced by mechanical stress, physical activity, availability of nutri... ...
Tập 23 Số 3 - Trang 160-170 - 2008
The mTOR Pathway in the Control of Protein SynthesisSignaling through mammalian target of rapamycin (mTOR) is activated by amino acids, insulin, and growth factors, and impaired by nutrient or energy deficiency. mTOR plays key roles in cell physiology. mTOR regulates numerous components involved in protein synthesis, including initiation and elongation factors, and the biogenesis of ribosomes themselves.
Tập 21 Số 5 - Trang 362-369 - 2006
Preeclampsia: The Role of Angiogenic Factors in Its PathogenesisPreeclampsia, a systemic syndrome of pregnancy clinically characterized by new onset of proteinuria and hypertension, is associated with significant morbidity and mortality to both mothers and fetuses. The pathogenesis of preeclampsia has been enigmatic; this review will focus on understanding the origins of this disorder. Preeclampsia originates in the placenta, starting with inadequate c... ...
Tập 24 Số 3 - Trang 147-158 - 2009
Maternal Uterine Vascular Remodeling During PregnancySufficient uteroplacental blood flow is essential for normal pregnancy outcome and is accomplished by the coordinated growth and remodeling of the entire uterine circulation, as well as the creation of a new fetal vascular organ: the placenta. The process of remodeling involves a number of cellular processes, including hyperplasia and hypertrophy, rearrangement of existing elements, and ch... ...
Tập 24 Số 1 - Trang 58-71 - 2009
The Molecular Physiology of Tight Junction PoresTight junctions form selective barriers that regulate paracellular transport across epithelia. A large family of tetraspanning cell-cell adhesion proteins called claudins create the barrier and regulate electrical resistance, size, and ionic charge selectivity. Study of inherited human claudin diseases and the outcome of the genetic manupulation of claudins in mice, Drosophila, and Caenorh... ...
Tập 19 Số 6 - Trang 331-338 - 2004
The Plastic Nature of the Vascular Wall: A Continuum of Remodeling Events Contributing to Control of Arteriolar Diameter and Structure The diameter of resistance arteries has a profound effect on the distribution of microvascular blood flow and the control of systemic blood pressure. Here, we review mechanisms that contribute to the regulation of resistance artery diameter, both acutely and chronically, their temporal characteristics, and their interdependence. Furthermore, we hypothesize the existence of a remodeling co... ...
Tập 24 Số 1 - Trang 45-57 - 2009
Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty Advancing age is associated with progressive declines in physiological function that lead to overt chronic disease, frailty, and eventual mortality. Importantly, age-related physiological changes occur in cellularity, insulin-responsiveness, secretory profiles, and inflammatory status of adipose tissue, leading to adipose tissue dysfunction. Although the mechanisms underlying adipose tiss... ...
Tập 32 Số 1 - Trang 9-19 - 2017
Cortactin: The Gray Eminence of the CytoskeletonCortactin, an actin filament-binding protein and target of multiple kinases, has emerged as a central element connecting signaling pathways with cytoskeleton restructuring. It is involved in a perplexingly diverse array of cellular processes, including cell motility, invasiveness, synaptogenesis, endocytosis, intercellular contact assembly, and host-pathogen interactions, where the common ... ...
Tập 21 Số 5 - Trang 352-361 - 2006