The Molecular Physiology of Tight Junction Pores

Physiology - Tập 19 Số 6 - Trang 331-338 - 2004
Christina M. Van Itallie1, James M. Anderson2
1Departments of Medicine, and
2Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599

Tóm tắt

Tight junctions form selective barriers that regulate paracellular transport across epithelia. A large family of tetraspanning cell-cell adhesion proteins called claudins create the barrier and regulate electrical resistance, size, and ionic charge selectivity. Study of inherited human claudin diseases and the outcome of the genetic manupulation of claudins in mice, Drosophila, and Caenorhabditis elegans are furthering our understanding of paracellular physiology.

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