Signaling in Muscle Atrophy and Hypertrophy

Physiology - Tập 23 Số 3 - Trang 160-170 - 2008
Marco Sandri1,2,3
1Department of Biomedical Sciences, University of Padova
2Department of Biomedical Sciences, University of Padova; Dulbecco Telethon Institute; and Venetian Institute of Molecular Medicine, Padova, Italy
3Dulbecco Telethon Institute

Tóm tắt

Muscle performance is influenced by turnover of contractile proteins. Production of new myofibrils and degradation of existing proteins is a delicate balance, which, depending on the condition, can promote muscle growth or loss. Protein synthesis and protein degradation are coordinately regulated by pathways that are influenced by mechanical stress, physical activity, availability of nutrients, and growth factors. Understanding the signaling that regulates muscle mass may provide potential therapeutic targets for the prevention and treatment of muscle wasting in metabolic and neuromuscular diseases.

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