Maternal Uterine Vascular Remodeling During Pregnancy

Physiology - Tập 24 Số 1 - Trang 58-71 - 2009
George Osol1, Maurizio Mandalà2
1Department of Obstetrics and Gynecology, University of Vermont College of Medicine, Burlington, Vermont; and
2University of Calabria, Cosenza, Italy

Tóm tắt

Sufficient uteroplacental blood flow is essential for normal pregnancy outcome and is accomplished by the coordinated growth and remodeling of the entire uterine circulation, as well as the creation of a new fetal vascular organ: the placenta. The process of remodeling involves a number of cellular processes, including hyperplasia and hypertrophy, rearrangement of existing elements, and changes in extracellular matrix. In this review, we provide information on uterine blood flow increases during pregnancy, the influence of placentation type on the distribution of uterine vascular resistance, consideration of the patterns, nature, and extent of maternal uterine vascular remodeling during pregnancy, and what is known about the underlying cellular mechanisms.

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