Hydroxylation of HIF-1: Oxygen Sensing at the Molecular Level

Physiology - Tập 19 Số 4 - Trang 176-182 - 2004
Gregg L. Semenza1,2,3
1Departments of Pediatrics, Medicine, Oncology, and Radiation Oncology
2Program in Vascular Cell Engineering
3Program in Vascular Cell Engineering; Departments of Pediatrics, Medicine, Oncology, and Radiation Oncology; and Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

Tóm tắt

The ability to sense and respond to changes in oxygenation represents a fundamental property of all metazoan cells. The discovery of the transcription factor HIF-1 has led to the identification of protein hydroxylation as a mechanism by which changes in Po2 are transduced to effect changes in gene expression.

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