The mTOR Pathway in the Control of Protein Synthesis

Physiology - Tập 21 Số 5 - Trang 362-369 - 2006
Xuemin Wang1, Christopher G. Proud1
1Department of Biochemistry & Molecular Biology, University of British Columbia, Life Sciences Centre, Vancouver, British Columbia, Canada,

Tóm tắt

Signaling through mammalian target of rapamycin (mTOR) is activated by amino acids, insulin, and growth factors, and impaired by nutrient or energy deficiency. mTOR plays key roles in cell physiology. mTOR regulates numerous components involved in protein synthesis, including initiation and elongation factors, and the biogenesis of ribosomes themselves.

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