Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty

Physiology - Tập 32 Số 1 - Trang 9-19 - 2017
Michael B. Stout1,2, Jamie N. Justice3, Barbara J. Nicklas3, James L. Kirkland4
1Department of Nutritional Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma;
2Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
3Department of Internal Medicine-Geriatrics, Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, North Carolina; and
4Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota

Tóm tắt

Advancing age is associated with progressive declines in physiological function that lead to overt chronic disease, frailty, and eventual mortality. Importantly, age-related physiological changes occur in cellularity, insulin-responsiveness, secretory profiles, and inflammatory status of adipose tissue, leading to adipose tissue dysfunction. Although the mechanisms underlying adipose tissue dysfunction are multifactorial, the consequences result in secretion of proinflammatory cytokines and chemokines, immune cell infiltration, an accumulation of senescent cells, and an increase in senescence-associated secretory phenotype (SASP). These processes synergistically promote chronic sterile inflammation, insulin resistance, and lipid redistribution away from subcutaneous adipose tissue. Without intervention, these effects contribute to age-related systemic metabolic dysfunction, physical limitations, and frailty. Thus adipose tissue dysfunction may be a fundamental contributor to the elevated risk of chronic disease, disability, and adverse health outcomes with advancing age.

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Tài liệu tham khảo

10.1007/BF03319104

10.1007/s00125-015-3751-0

10.1038/nm0909-996

10.1038/nature16932

10.1038/nature10600

10.1016/j.cyto.2015.05.005

Bapat SP, 2015, Nature, 528, 137, 10.1038/nature16151

10.2337/diabetes.50.10.2384

10.1038/oby.2004.250

10.1038/sj.ejcn.1601025

10.3945/ajcn.112.047860

10.1111/acel.12095

10.1093/gerona/glp175

10.1016/j.exger.2011.11.008

10.1126/science.1078223

10.1007/s00592-012-0413-2

10.1016/j.cell.2004.09.027

10.1016/j.cell.2005.02.003

10.1093/gerona/glp213

10.1016/j.metabol.2012.08.007

10.1093/ajcn/82.2.428

10.1038/nm.4010

10.1074/jbc.M210811200

10.1093/gerona/glv169

10.1210/en.2006-0536

10.1530/JOE-15-0533

10.1016/S0140-6736(12)62167-9

10.1016/j.cell.2007.07.003

10.1146/annurev-pathol-121808-102144

10.1371/journal.pbio.0060301

10.1038/oby.2000.33

10.2337/diabetes.52.7.1799

10.1172/JCI73658

10.1111/j.1532-5415.1999.tb01583.x

10.1038/nm.2002

10.1002/oby.20615

10.1016/j.cell.2015.02.020

10.1161/CIRCULATIONAHA.106.675355

10.1093/gerona/glu057

10.1093/gerona/56.3.M146

10.1093/gerona/56.3.M146

10.1093/gerona/glp076

10.1615/CritRevImmunol.2013006833

10.1016/0026-0495(92)90296-M

10.1152/ajpendo.00557.2006

10.1093/gerona/55.4.M221

10.1056/NEJM199503023320902

10.1152/ajpendo.00377.2009

10.2337/diacare.25.11.2016

10.1007/s13539-012-0068-4

10.1073/pnas.1412759111

10.1126/science.7678183

10.1093/gerona/54.5.B183

10.2337/db08-1770

10.1210/en.2006-0692

10.1152/japplphysiol.00608.2014

10.1152/ajpregu.2001.280.6.R1772

10.1074/jbc.M513187200

10.2337/db15-0403

10.1016/j.exger.2012.11.014

10.1152/ajpcell.1990.258.2.C206

10.1016/j.exger.2014.10.012

10.2337/dc12-1801

10.2337/diabetes.52.11.2784

10.1007/s11357-011-9269-6

10.1016/j.cmet.2015.03.005

10.1016/j.arr.2009.06.001

10.1016/j.arcmed.2005.01.003

10.1159/000382054

10.1186/1742-4933-2-8

10.1152/jappl.1997.83.5.1581

10.1016/j.cell.2013.05.039

10.2527/jas.2007-0462

10.1186/1758-5996-5-31

10.1172/JCI29881

10.4049/jimmunol.1102188

10.1152/ajpendo.90851.2008

10.1038/ncomms3192

10.1074/jbc.M311980200

10.2337/db10-1278

10.1038/nm.2014

10.1016/j.exger.2014.01.024

10.1093/gerona/59.2.M139

10.1093/ageing/afp105

10.1038/nature08636

10.1172/JCI28721

10.1016/S0092-8674(03)00401-X

10.1080/13813450802181047

10.1038/nm.2627

10.2174/138161206777947533

10.2337/db14-1820

10.1007/s10522-014-9536-x

10.2337/db14-0796

10.1161/01.ATV.0000065636.15310.9C

10.1001/jama.286.3.327

10.1096/fj.05-4607fje

10.1097/JES.0b013e31823b5f13

10.1101/gad.6.3.439

10.1111/acel.12458

10.2337/db15-0291

10.1097/SAP.0b013e3181723bbe

10.1016/S0140-6736(99)01046-6

10.2337/diabetes.51.12.3391

10.1172/JCI29069

10.1113/expphysiol.2010.054189

10.1111/j.1532-5415.2010.02764.x

10.1097/00075197-200405000-00005

10.1093/gerona/glp046

10.1016/j.cmet.2010.11.011

Stout M, Adipose Tissue and Adipokines in Health and Disease, 201469

10.18632/oncotarget.5760

10.18632/oncotarget.3997

10.18632/aging.100681

10.1001/jama.2010.1923

10.1016/S0140-6736(05)61032-X

10.1152/ajpendo.00202.2006

10.1111/j.1474-9726.2010.00608.x

10.1152/ajpendo.00295.2007

10.1016/j.cmet.2013.03.008

10.1172/JCI64098

10.1038/nature02866

10.1007/s13679-013-0059-6

10.1093/gerona/60.3.324

10.1046/j.1532-5415.2002.50217.x

10.1001/archinte.162.20.2333

10.4049/jimmunol.179.7.4829

10.1172/JCI200319451

10.7554/eLife.12997

10.1073/pnas.1515386112

10.1111/acel.12445

10.1111/acel.12344

10.1002/oby.21053

10.1301/00296640260085949

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Physiology

Tập 32 Số 1

9-19

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