Journal of Biomedical Materials Research - Part A
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Flow perfusion culture of marrow stromal osteoblasts in titanium fiber meshAbstract The objective of this study was to evaluate the effect of two cell culture techniques, static and flow perfusion, on the osteogenic expression of rat bone marrow cells seeded into titanium fiber mesh for a period up to 16 days. A cell suspension of rat bone marrow stromal osteoblasts (5 × 105 cells/300 μL) was seeded into the mesh mater... ... hiện toàn bộ
Journal of Biomedical Materials Research - Part A - Tập 64A Số 2 - Trang 235-241 - 2003
MMP‐2 sensitive, VEGF‐bearing bioactive hydrogels for promotion of vascular healingAbstract We sought to develop bioactive hydrogels to facilitate arterial healing, e.g., after balloon angioplasty. Toward this end, we developed a new class of proteolytically sensitive, biologically active polyethylene glycol (PEG)‐peptide hydrogels that can be formed in situ to temporarily protect the arterial injury from blood contact. ... ... hiện toàn bộ
Journal of Biomedical Materials Research - Part A - Tập 68A Số 4 - Trang 704-716 - 2004
Controlled release of tethered molecules via engineered hydrogel degradation: Model development and validationAbstract A statistical‐co‐kinetic model has been developed to predict effects of hydrolytic or enzymatic degradation on the macroscopic properties of hydrogels formed through Michael‐type addition reactions. Important parameters accounted for by the theoretical calculations are bond cleavage kinetics, microstructural network characteristics such as macromer function... ... hiện toàn bộ
Journal of Biomedical Materials Research - Part A - Tập 74A Số 1 - Trang 104-116 - 2005
Biomaterial topography alters healing in vivo and monocyte/macrophage activation in vitroAbstract The effect of biomaterial topography on healing in vivo and monocyte/macrophage stimulation in vitro was assessed. A series of expanded polytetrafluoroethylene (ePTFE) materials were characterized by increasing average intranodal distance of 1.2 μm (1.2‐ePTFE), 3.0 μm (3.0‐ePTFE), and 4.4 μm (4.4‐ePTFE),... ... hiện toàn bộ
Journal of Biomedical Materials Research - Part A - Tập 95A Số 2 - Trang 649-657 - 2010
Biomimetic control of vascular smooth muscle cell morphology and phenotype for functional tissue‐engineered small‐diameter blood vesselsAbstract Small‐diameter blood vessel substitutes are urgently needed for patients requiring replacements of their coronary and below‐the‐knee vessels and for better arteriovenous dialysis shunts. Circulatory diseases, especially those arising from atherosclerosis, are the predominant cause of mortality and morbidity in the developed world. Current therapies include ... ... hiện toàn bộ
Journal of Biomedical Materials Research - Part A - Tập 88A Số 4 - Trang 1104-1121 - 2009
Monocyte/lymphocyte interactions and the foreign body response: In vitro effects of biomaterial surface chemistryAbstract To determine the effect of biomaterial surface chemistry on leukocyte interaction and activity at the material/tissue interface, human peripheral blood monocytes and lymphocytes were cultured on a series of poly(ethylene terephthalate) (PET)‐based biomaterials. Both monocytes and lymphocytes were isolated from whole human blood and separated by a nonadheren... ... hiện toàn bộ
Journal of Biomedical Materials Research - Part A - Tập 74A Số 3 - Trang 285-293 - 2005
Vitronectin is a critical protein adhesion substrate for IL‐4‐induced foreign body giant cell formationAbstract An in vitro system of interleukin (IL)‐4‐induced foreign body giant cell (FBGC) formation was utilized to define the adhesion protein substrate(s) that promotes this aspect of the foreign body reaction on biomedical polymers. Human monocytes were cultured on cell culture polystyrene surfaces that had been pre‐adsorbed with a synth... ... hiện toàn bộ
Journal of Biomedical Materials Research - Part A - Tập 86A Số 2 - Trang 535-543 - 2008
Surface characterizations and corrosion resistance of nickel–titanium orthodontic archwires in artificial saliva of various degrees of acidityAbstract This study investigated the surface characterizations and corrosion resistance of as‐received commercial nickel–titanium (NiTi) dental orthodontic archwires from different manufacturers using a cyclic potentiodynamic test in artificial saliva with various acidities. An atomic force microscope was used to evaluate the surface topography of the NiTi wires. Th... ... hiện toàn bộ
Journal of Biomedical Materials Research - Part A - Tập 74A Số 4 - Trang 629-639 - 2005
Conformation change of bovine serum albumin induced by bioactive titanium metals and its effects on cell behaviorsThe conformation change of bovine serum albumin (BSA) induced by bioactive titanium surfaces, including acid‐alkali‐treated titanium (AA‐Ti) and alkali–heat‐treated titanium (AH‐Ti), was studied, and its effects on the activity of MC3T3‐E1 cell were evaluated. Pure titanium metal (P‐Ti) was used as control. The AA‐Ti could adsorb more BSA on its surface than AH‐Ti and P‐Ti. The α‐helix par... ... hiện toàn bộ
Journal of Biomedical Materials Research - Part A - Tập 102 Số 4 - Trang 1053-1062 - 2014
Osteoblasts behavior on chemically treated commercially pure titanium surfacesAbstract Surface modifications of commercially pure titanium (Cp‐Ti), a material widely used to produce dental implants, can induce specific responses on osteoblastic cells after implantation. This work aims to investigate the influence of chemically modified surfaces of Cp‐Ti by acid etching or acid etching plus alkaline treatment on the gene expression of human os... ... hiện toàn bộ
Journal of Biomedical Materials Research - Part A - Tập 102 Số 6 - Trang 1816-1822 - 2014
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