Antimicrobial effect of silver‐doped phosphate‐based glasses

Journal of Biomedical Materials Research - Part A - Tập 79A Số 3 - Trang 618-626 - 2006
Ifty Ahmed1, Derren Ready2, Martin Wilson3, Jonathan C. Knowles1
1Division of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, 256 Gray's Inn Road, London WC1X 8LD, United Kingdom
2UCLH NHS Foundation Trust, Eastman Dental Hospital, 256 Gray's Inn Road, London, WC1X 8LD, United Kingdom
3Division of Microbial Diseases, UCL Eastman Dental Institute, 256 Gray's Inn Road, London, WC1X 8LD, United Kingdom

Tóm tắt

AbstractIn this study a range of phosphate‐based glasses (PBG) doped with silver have been investigated for their antimicrobial activities. In disk diffusion assays, these compositions demonstrated microbistatic effects against a range of organisms including Staphylococcus aureus, Escherichia coli, Bacillus cereus, Pseudomonas aeruginosa, methicillin‐resistant Staphylococcus aureus, and Candida albicans. The data obtained from the above studies allowed for an additional range of PBG containing lower amounts of silver to be studied for their effects on the growth and viability of S. aureus, E. coli, and C. albicans. PBG containing 3 and 5 mol % Ag were bactericidal for S. aureus and E. coli and significantly decreased the growth rate of C. albicans. A decrease in the dissolution rates of the glasses was seen with increasing Ag content over the range of concentrations investigated. Overall, 3 mol % Ag incorporated into the PBG investigated was sufficient to mount a potent antibacterial effect against the test organisms, and these compositions also gave excellent long‐term release of Ag ions into the medium. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006

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Journal of Biomedical Materials Research - Part A

Tập 79A Số 3

618-626

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