Increased osteoblast adhesion on titanium‐coated hydroxylapatite that forms CaTiO3

Journal of Biomedical Materials Research - Part A - Tập 67A Số 3 - Trang 975-980 - 2003
Thomas J. Webster1, Celaletdin Ergun2, Robert H. Doremus3, W. A. Lanford4
1Department of Biomedical Engineering; Purdue University, West Lafayette, Indiana 47907
2Istanbul Technical University, Department of Mechanical Engineering, Taksim, Istanbul, Turkey
3Department of Materials Science and Engineering, Rennselaer Polytechnic Institute, Troy, New York 12180
4Department of Physics, University at Albany, State University of New York, Albany, New York 12222

Tóm tắt

AbstractCaTiO3 is a strong candidate to form at the interface between hydroxylapatite (HA) and titanium implants during many coating procedures. However, few studies have compared the cytocompatibility properties of CaTiO3 to HA pertinent for bone–cell function. For this reason, the objective of the present in vitro study was to determine the ability of bone‐forming cells (osteoblasts) to adhere on titanium coated with HA that resulted in the formation of CaTiO3. To accomplish the formation of CaTiO3, titanium was coated on HA discs and annealed either under air or a N2+H2 environment. Materials were characterized by X‐ray diffraction (XRD), Rutherford backscattering spectroscopy (RBS), and atomic force microscopy (AFM). These characterization techniques demonstrated the formation of a nanometer rough CaTiO3 layer as a consequence of interactions between HA and titanium during coating conditions. Results from cytocompatibility tests revealed increased osteoblast adhesion on materials that contained CaTiO3 compared to both pure HA and uncoated titanium. The greatest osteoblast adhesion was observed on titanium‐coated HA annealed under air conditions. Because adhesion is a crucial prerequisite to subsequent functions of osteoblasts (such as the deposition of calcium containing mineral), the present in vitro results imply that orthopedic coatings that form CaTiO3 could increase osseointegration with juxtaposed bone needed for increased implant efficacy. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res 67A: 975–980, 2003

Từ khóa


Tài liệu tham khảo

10.1016/S0142-9612(97)00024-0

10.1016/S0257-8972(94)80037-5

Brossa F, 1993, Adhesion properties of plasma sprayed hydroxyapatite coatings for orthopaedic prostheses, Bio‐Med Mater Eng, 3, 127, 10.3233/BME-1993-3302

10.1002/jbm.1072

10.1016/0142-9612(90)90005-B

10.1002/jbm.10003

de MoraesSVM RibeiroKM OgasawaraT SoaresGA.Calcium phosphate electrophoretically deposited on metallic substrates. 15thSymposium on Apatite;1999. p41–44.

10.1016/0142-9612(92)90192-Q

10.1002/(SICI)1097-4636(19980315)39:4<524::AID-JBM3>3.0.CO;2-L

10.1002/(SICI)1097-4636(199710)37:1<60::AID-JBM8>3.0.CO;2-H

10.1002/(SICI)1097-4636(19991215)47:4<551::AID-JBM12>3.0.CO;2-C

10.1002/(SICI)1097-4636(199605)31:1<81::AID-JBM10>3.0.CO;2-P

SatoM SlamovichE WebsterTJ.Enhanced osteoblast adhesion on a novel hydroxyapatite coating. Materials Research Society Annual Spring Meeting Conference Proceedings;2003. 07.33.

de Groot K, 1998, Calcium phosphate coating: Alternatives to plasma spray, Bioceramics, 11, 41

LeGeros RZ, 1995, 1429

Aoki H, 1994, Medical applications of hydroxyapatite

10.1002/jbm.1246

10.1016/S0142-9612(99)00020-4

10.1111/j.1600-0757.1998.tb00121.x

10.1016/S0065-2377(01)27005-7

10.1002/1097-4636(20000905)51:3<475::AID-JBM23>3.0.CO;2-9

10.1089/10763270152044152

Bujursten LM, 1991, The bone–biomaterial interface, 165

10.1016/0142-9612(91)90057-H

Thông tin
Thông tin xuất bản

Journal of Biomedical Materials Research - Part A

Tập 67A Số 3

975-980

Thông tin tác giả