Basic and Therapeutic Aspects of Angiogenesis

Cell - Tập 146 - Trang 873-887 - 2011
Michael Potente1,2, Holger Gerhardt3,4, Peter Carmeliet5,6
1Vascular Epigenetics Group, Institute for Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University, D-60590 Frankfurt, Germany
2Department of Cardiology, Internal Medicine III, Goethe University, D-60590 Frankfurt, Germany
3Vascular Biology Laboratory, London Research Institute, Cancer Research UK, London WC2A 3LY, UK
4Independent consultant for Vascular Patterning Laboratory, Vesalius Research Center, VIB, B-3000 Leuven, Belgium
5Laboratory of Angiogenesis & Neurovascular link, Vesalius Research Center, K.U.Leuven, B-3000 Leuven, Belgium
6Laboratory of Angiogenesis & Neurovascular link, Vesalius Research Center, VIB, B-3000 Leuven, Belgium

Tài liệu tham khảo

Adams, 2007, Molecular regulation of angiogenesis and lymphangiogenesis, Nat. Rev. Mol. Cell Biol., 8, 464, 10.1038/nrm2183

Adams, 2010, Axon guidance molecules in vascular patterning, Cold Spring Harb. Perspect. Biol., 2, a001875, 10.1101/cshperspect.a001875

Arroyo, 2010, Extracellular matrix, inflammation, and the angiogenic response, Cardiovasc. Res., 86, 226, 10.1093/cvr/cvq049

Augustin, 2009, Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system, Nat. Rev. Mol. Cell Biol., 10, 165, 10.1038/nrm2639

Bagri, 2010, Use of anti-VEGF adjuvant therapy in cancer: challenges and rationale, Trends Mol. Med., 16, 122, 10.1016/j.molmed.2010.01.004

Beenken, 2009, The FGF family: biology, pathophysiology and therapy, Nat. Rev. Drug Discov., 8, 235, 10.1038/nrd2792

Bentley, 2009, Tipping the balance: robustness of tip cell selection, migration and fusion in angiogenesis, PLoS Comput. Biol., 5, e1000549, 10.1371/journal.pcbi.1000549

Bergers, 2008, Modes of resistance to anti-angiogenic therapy, Nat. Rev. Cancer, 8, 592, 10.1038/nrc2442

Blasi, 2002, uPAR: a versatile signalling orchestrator, Nat. Rev. Mol. Cell Biol., 3, 932, 10.1038/nrm977

Bonauer, 2010, Vascular microRNAs, Curr. Drug Targets, 11, 943, 10.2174/138945010791591313

Butler, 2010, Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors, Nat. Rev. Cancer, 10, 138, 10.1038/nrc2791

Carmeliet, 2003, Angiogenesis in health and disease, Nat. Med., 9, 653, 10.1038/nm0603-653

Carmeliet, 2011, Molecular mechanisms and clinical applications of angiogenesis, Nature, 473, 298, 10.1038/nature10144

Carmeliet, 2005, Common mechanisms of nerve and blood vessel wiring, Nature, 436, 193, 10.1038/nature03875

Castets, 2010, Netrin-1 role in angiogenesis: to be or not to be a pro-angiogenic factor?, Cell Cycle, 9, 1466, 10.4161/cc.9.8.11197

Cavallaro, 2011, Adhesion molecule signalling: not always a sticky business, Nat. Rev. Mol. Cell Biol., 12, 189, 10.1038/nrm3068

Chappell, 2010, Vascular development: genetic mechanisms and links to vascular disease, Curr. Top. Dev. Biol., 90, 43, 10.1016/S0070-2153(10)90002-1

Corada, 2010, The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling, Dev. Cell, 18, 938, 10.1016/j.devcel.2010.05.006

Crawford, 2009, Tumor and stromal pathways mediating refractoriness/resistance to anti-angiogenic therapies, Trends Pharmacol. Sci., 30, 624, 10.1016/j.tips.2009.09.004

Crawford, 2009, VEGF inhibition: insights from preclinical and clinical studies, Cell Tissue Res., 335, 261, 10.1007/s00441-008-0675-8

De Palma, 2009, Tie2-expressing monocytes (TEMs): novel targets and vehicles of anticancer therapy?, Biochim. Biophys. Acta, 1796, 5

De Smet, 2009, Mechanisms of vessel branching: filopodia on endothelial tip cells lead the way, Arterioscler. Thromb. Vasc. Biol., 29, 639, 10.1161/ATVBAHA.109.185165

Desgrosellier, 2010, Integrins in cancer: biological implications and therapeutic opportunities, Nat. Rev. Cancer, 10, 9, 10.1038/nrc2748

Ding, 2010, Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration, Nature, 468, 310, 10.1038/nature09493

Dyer, 2010, Development of the endothelium: an emphasis on heterogeneity, Semin. Thromb. Hemost., 36, 227, 10.1055/s-0030-1253446

Eble, 2009, The extracellular matrix of blood vessels, Curr. Pharm. Des., 15, 1385, 10.2174/138161209787846757

Ebos, 2011, Antiangiogenic therapy: impact on invasion, disease progression, and metastasis, Nat. Rev. Clin. Oncol., 8, 210, 10.1038/nrclinonc.2011.21

Eilken, 2010, Dynamics of endothelial cell behavior in sprouting angiogenesis, Curr. Opin. Cell Biol., 22, 617, 10.1016/j.ceb.2010.08.010

Erez, 2010, Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kappaB-dependent manner, Cancer Cell, 17, 135, 10.1016/j.ccr.2009.12.041

Falk, 2010, Adherens junctions remain dynamic, BMC Biol., 8, 34, 10.1186/1741-7007-8-34

Fang, 2011, Stem cells in tumor angiogenesis, J. Mol. Cell. Cardiol., 50, 290, 10.1016/j.yjmcc.2010.10.024

Fantin, 2009, Neuropilin ligands in vascular and neuronal patterning, Biochem. Soc. Trans., 37, 1228, 10.1042/BST0371228

Fantin, 2010, Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction, Blood, 116, 829, 10.1182/blood-2009-12-257832

Ferrara, 2010, Pathways mediating VEGF-independent tumor angiogenesis, Cytokine Growth Factor Rev., 21, 21, 10.1016/j.cytogfr.2009.11.003

Ferrara, 2010, Role of myeloid cells in vascular endothelial growth factor-independent tumor angiogenesis, Curr. Opin. Hematol., 17, 219

Fischer, 2008, FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy?, Nat. Rev. Cancer, 8, 942, 10.1038/nrc2524

Folkman, 1971, Tumor angiogenesis: therapeutic implications, N. Engl. J. Med., 285, 1182, 10.1056/NEJM197111182852108

Folkman, 2007, Angiogenesis: an organizing principle for drug discovery?, Nat. Rev. Drug Discov., 6, 273, 10.1038/nrd2115

Fraisl, 2009, Regulation of angiogenesis by oxygen and metabolism, Dev. Cell, 16, 167, 10.1016/j.devcel.2009.01.003

Francia, 2011, Mouse models of advanced spontaneous metastasis for experimental therapeutics, Nat. Rev. Cancer, 11, 135, 10.1038/nrc3001

Franco, 2009, Vascular morphogenesis: a Wnt for every vessel?, Curr. Opin. Genet. Dev., 19, 476, 10.1016/j.gde.2009.09.004

Gaengel, 2009, Endothelial-mural cell signaling in vascular development and angiogenesis, Arterioscler. Thromb. Vasc. Biol., 29, 630, 10.1161/ATVBAHA.107.161521

Gerhardt, 2008, Pericytes: gatekeepers in tumour cell metastasis?, J. Mol. Med., 86, 135, 10.1007/s00109-007-0258-2

Goel, 2011, Normalization of the vasculature for treatment of cancer and other diseases, Physiol. Rev., 91, 1071, 10.1152/physrev.00038.2010

Gridley, 2010, Notch signaling in the vasculature, Curr. Top. Dev. Biol., 92, 277, 10.1016/S0070-2153(10)92009-7

Grivennikov, 2010, Immunity, inflammation, and cancer, Cell, 140, 883, 10.1016/j.cell.2010.01.025

Guarani, 2011, Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase, Nature, 473, 234, 10.1038/nature09917

Hagberg, 2010, Vascular endothelial growth factor B controls endothelial fatty acid uptake, Nature, 464, 917, 10.1038/nature08945

Herbert, 2009, Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation, Science, 326, 294, 10.1126/science.1178577

Huang, 2010, Targeting the ANGPT-TIE2 pathway in malignancy, Nat. Rev. Cancer, 10, 575, 10.1038/nrc2894

Iruela-Arispe, 2009, Cellular and molecular mechanisms of vascular lumen formation, Dev. Cell, 16, 222, 10.1016/j.devcel.2009.01.013

Jain, 2003, Molecular regulation of vessel maturation, Nat. Med., 9, 685, 10.1038/nm0603-685

Jain, 2005, Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy, Science, 307, 58, 10.1126/science.1104819

Jain, 2009, Biomarkers of response and resistance to antiangiogenic therapy, Nat. Rev. Clin. Oncol., 6, 327, 10.1038/nrclinonc.2009.63

Jakobsson, 2010, Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting, Nat. Cell Biol., 12, 943, 10.1038/ncb2103

Jeansson, 2011, Angiopoietin-1 is essential in mouse vasculature during development and in response to injury, J. Clin. Invest., 121, 2278, 10.1172/JCI46322

Jones, 2006, What determines blood vessel structure? Genetic prespecification vs. hemodynamics, Physiology (Bethesda), 21, 388, 10.1152/physiol.00020.2006

Kerbel, 2008, Tumor angiogenesis, N. Engl. J. Med., 358, 2039, 10.1056/NEJMra0706596

Kim, 2011, Semaphorin 3E-Plexin-D1 signaling regulates VEGF function in developmental angiogenesis via a feedback mechanism, Genes Dev., 25, 1399, 10.1101/gad.2042011

Koch, 2011, Robo4 maintains vessel integrity and inhibits angiogenesis by interacting with UNC5B, Dev. Cell, 20, 33, 10.1016/j.devcel.2010.12.001

Leblanc, 2009, Biology of vascular malformations of the brain, Stroke, 40, e694, 10.1161/STROKEAHA.109.563692

Liu, 2011, Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice, J. Clin. Invest., 121, 800, 10.1172/JCI43114

London, 2009, Emerging mechanisms of vascular stabilization, J. Thromb. Haemost., 7, 57, 10.1111/j.1538-7836.2009.03421.x

Lucke, 2010, Endothelial functions of sphingosine-1-phosphate, Cell. Physiol. Biochem., 26, 87, 10.1159/000315109

Majmundar, 2010, Hypoxia-inducible factors and the response to hypoxic stress, Mol. Cell, 40, 294, 10.1016/j.molcel.2010.09.022

Makanya, 2009, Intussusceptive angiogenesis and its role in vascular morphogenesis, patterning, and remodeling, Angiogenesis, 12, 113, 10.1007/s10456-009-9129-5

Mazzieri, 2011, Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells, Cancer Cell, 19, 512, 10.1016/j.ccr.2011.02.005

Mazzone, 2009, Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization, Cell, 136, 839, 10.1016/j.cell.2009.01.020

Miles, 2011, Disease course patterns after discontinuation of bevacizumab: pooled analysis of randomized phase III trials, J. Clin. Oncol., 29, 83, 10.1200/JCO.2010.30.2794

Murakami, 2008, The FGF system has a key role in regulating vascular integrity, J. Clin. Invest., 118, 3355, 10.1172/JCI35298

Nicoli, 2010, MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis, Nature, 464, 1196, 10.1038/nature08889

Nisancioglu, 2010, The absence of pericytes does not increase the sensitivity of tumor vasculature to vascular endothelial growth factor-A blockade, Cancer Res., 70, 5109, 10.1158/0008-5472.CAN-09-4245

Norden, 2009, Antiangiogenic therapies for high-grade glioma, Nat. Rev. Neurol., 5, 610, 10.1038/nrneurol.2009.159

Nyberg, 2005, Endogenous inhibitors of angiogenesis, Cancer Res., 65, 3967, 10.1158/0008-5472.CAN-04-2427

Nyberg, 2008, Tumor microenvironment and angiogenesis, Front. Biosci., 13, 6537, 10.2741/3173

Padera, 2008, Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib, Mol. Cancer Ther., 7, 2272, 10.1158/1535-7163.MCT-08-0182

Pardali, 2010, Signaling by members of the TGF-beta family in vascular morphogenesis and disease, Trends Cell Biol., 20, 556, 10.1016/j.tcb.2010.06.006

Phng, 2009, Angiogenesis: a team effort coordinated by notch, Dev. Cell, 16, 196, 10.1016/j.devcel.2009.01.015

Phng, 2009, Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis, Dev. Cell, 16, 70, 10.1016/j.devcel.2008.12.009

Pietras, 2010, Hallmarks of cancer: interactions with the tumor stroma, Exp. Cell Res., 316, 1324, 10.1016/j.yexcr.2010.02.045

Pitulescu, 2010, Eph/ephrin molecules—a hub for signaling and endocytosis, Genes Dev., 24, 2480, 10.1101/gad.1973910

Qian, 2010, Macrophage diversity enhances tumor progression and metastasis, Cell, 141, 39, 10.1016/j.cell.2010.03.014

Quaegebeur, 2010, Pericytes: blood-brain barrier safeguards against neurodegeneration?, Neuron, 68, 321, 10.1016/j.neuron.2010.10.024

Rolny, 2011, HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF, Cancer Cell, 19, 31, 10.1016/j.ccr.2010.11.009

Roukens, 2010, Control of endothelial sprouting by a Tel-CtBP complex, Nat. Cell Biol., 12, 933, 10.1038/ncb2096

Sawamiphak, 2010, Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis, Nature, 465, 487, 10.1038/nature08995

Schaper, 2009, Collateral circulation: past and present, Basic Res. Cardiol., 104, 5, 10.1007/s00395-008-0760-x

Schmidt, 2011, Loss or inhibition of stromal-derived PlGF prolongs survival of mice with imatinib-resistant Bcr-Abl1(+) leukemia, Cancer Cell, 19, 740, 10.1016/j.ccr.2011.05.007

Serini, 2009, Semaphorins and tumor angiogenesis, Angiogenesis, 12, 187, 10.1007/s10456-009-9138-4

Strilić, 2009, The molecular basis of vascular lumen formation in the developing mouse aorta, Dev. Cell, 17, 505, 10.1016/j.devcel.2009.08.011

Swift, 2009, Arterial-venous specification during development, Circ. Res., 104, 576, 10.1161/CIRCRESAHA.108.188805

Tammela, 2008, Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation, Nature, 454, 656, 10.1038/nature07083

Thurston, 2007, The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth, Nat. Rev. Cancer, 7, 327, 10.1038/nrc2130

Van Cutsem, 2011, Lessons from the adjuvant bevacizumab trial on colon cancer: what next?, J. Clin. Oncol., 29, 1, 10.1200/JCO.2010.32.2701

Wang, 2010, Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis, Nature, 465, 483, 10.1038/nature09002

Warren, 2010, Signaling circuitry in vascular morphogenesis, Curr. Opin. Hematol., 17, 213

Wels, 2008, Migratory neighbors and distant invaders: tumor-associated niche cells, Genes Dev., 22, 559, 10.1101/gad.1636908

Xu, 2011, Blood vessel tubulogenesis requires Rasip1 regulation of GTPase signaling, Dev. Cell, 20, 526, 10.1016/j.devcel.2011.02.010

Yan, 2010, Chronic DLL4 blockade induces vascular neoplasms, Nature, 463, E6, 10.1038/nature08751

Zeeb, 2010, Resolving cell-cell junctions: lumen formation in blood vessels, Curr. Opin. Cell Biol., 22, 626, 10.1016/j.ceb.2010.07.003

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