Signaling by members of the TGF-β family in vascular morphogenesis and disease
Tài liệu tham khảo
Adams, 2007, Molecular regulation of angiogenesis and lymphangiogenesis, Nat. Rev. Mol. Cell Biol., 8, 464, 10.1038/nrm2183
Carmeliet, 2005, Angiogenesis in life, disease and medicine, Nature, 438, 932, 10.1038/nature04478
Folkman, 1996, Blood vessel formation: what is its molecular basis?, Cell, 87, 1153, 10.1016/S0092-8674(00)81810-3
Ribatti, 2007, The discovery of endothelial progenitor cells. An historical review, Leuk. Res., 31, 439, 10.1016/j.leukres.2006.10.014
Betsholtz, 2005, Role of pericytes in vascular morphogenesis, EXS, 94, 115
Risau, 1997, Mechanisms of angiogenesis, Nature, 386, 671, 10.1038/386671a0
Stehbens, 1996, Structural and architectural changes during arterial development and the role of hemodynamics, Acta Anat. (Basel), 157, 261, 10.1159/000147889
Swift, 2009, Arterial–venous specification during development, Circ. Res., 104, 576, 10.1161/CIRCRESAHA.108.188805
Carmeliet, 2000, Angiogenesis in cancer and other diseases, Nature, 407, 249, 10.1038/35025220
Hanahan, 1996, Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis, Cell, 86, 353, 10.1016/S0092-8674(00)80108-7
Gerhardt, 2003, VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia, J. Cell Biol., 161, 1163, 10.1083/jcb.200302047
Kamei, 2006, Endothelial tubes assemble from intracellular vacuoles in vivo, Nature, 442, 453, 10.1038/nature04923
Stalmans, 2002, Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms, J. Clin. Invest., 109, 327, 10.1172/JCI0214362
Hellstrom, 2007, Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis, Nature, 445, 776, 10.1038/nature05571
Suchting, 2007, The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching, Proc. Natl. Acad. Sci. U. S. A., 104, 3225, 10.1073/pnas.0611177104
von Tell, 2006, Pericytes and vascular stability, Exp. Cell Res., 312, 623, 10.1016/j.yexcr.2005.10.019
Heldin, 1997, TGF-β signalling from cell membrane to nucleus through SMAD proteins, Nature, 390, 465, 10.1038/37284
Schmierer, 2007, TGFβ–SMAD signal transduction: molecular specificity and functional flexibility, Nat. Rev. Mol. Cell Biol., 8, 970, 10.1038/nrm2297
Guo, 2009, Signaling cross-talk between TGF-beta/BMP and other pathways, Cell Res., 19, 71, 10.1038/cr.2008.302
ten Dijke, 2007, Extracellular control of TGFβ signalling in vascular development and disease, Nat. Rev. Mol. Cell Biol., 8, 857, 10.1038/nrm2262
Constam, 1999, Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases, J. Cell Biol., 144, 139, 10.1083/jcb.144.1.139
ten Dijke, 2008, Endoglin in angiogenesis and vascular diseases, Angiogenesis, 11, 79, 10.1007/s10456-008-9101-9
Oh, 2000, Activin receptor-like kinase 1 modulates transforming growth factor-β1 signaling in the regulation of angiogenesis, Proc. Natl. Acad. Sci. U. S. A., 97, 2626, 10.1073/pnas.97.6.2626
Beppu, 2004, BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia, Am. J. Physiol. Lung Cell Mol. Physiol., 287, L1241, 10.1152/ajplung.00239.2004
Venkatesha, 2006, Soluble endoglin contributes to the pathogenesis of preeclampsia, Nat. Med., 12, 642, 10.1038/nm1429
Chen, 2009, Smad7 is required for the development and function of the heart, J. Biol. Chem., 284, 292, 10.1074/jbc.M807233200
Park, 2008, ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2, Blood, 111, 633, 10.1182/blood-2007-08-107359
Seki, 2006, Nonoverlapping expression patterns of ALK1 and ALK5 reveal distinct roles of each receptor in vascular development, Lab. Invest., 86, 116, 10.1038/labinvest.3700376
Carvalho, 2004, Defective paracrine signalling by TGFβ in yolk sac vasculature of endoglin mutant mice: a paradigm for hereditary hemorrhagic telangiectasia, Development, 131, 6237, 10.1242/dev.01529
Carvalho, 2007, Compensatory signalling induced in the yolk sac vasculature by deletion of TGFβ receptors in mice, J. Cell Sci., 120, 4269, 10.1242/jcs.013169
Gallione, 2004, A combined syndrome of juvenile polyposis and hereditary hemorrhagic telangiectasia associated with mutations in MADH4 (SMAD4), Lancet, 363, 852, 10.1016/S0140-6736(04)15732-2
Park, 2009, Real-time imaging of de novo arteriovenous malformation in a mouse model of hereditary hemorrhagic telangiectasia, J. Clin. Invest., 119, 3487
Sorensen, 2003, Loss of distinct arterial and venous boundaries in mice lacking endoglin, a vascular-specific TGFβ coreceptor, Dev. Biol., 261, 235, 10.1016/S0012-1606(03)00158-1
Roman, 2002, Disruption of acvrl1 increases endothelial cell number in zebrafish cranial vessels, Development, 129, 3009, 10.1242/dev.129.12.3009
Mancini, 2009, Endoglin plays distinct roles in vascular smooth muscle cell recruitment and regulation of arteriovenous identity during angiogenesis, Dev. Dyn., 238, 2479, 10.1002/dvdy.22066
Mahmoud, 2010, Pathogenesis of arteriovenous malformations in the absence of endoglin, Circ. Res., 106, 1425, 10.1161/CIRCRESAHA.109.211037
Blokzijl, 2003, Cross-talk between the Notch and TGF-β signaling pathways mediated by interaction of the Notch intracellular domain with Smad3, J. Cell Biol., 163, 723, 10.1083/jcb.200305112
Niimi, 2007, Notch signaling is necessary for epithelial growth arrest by TGF-β, J. Cell Biol., 176, 695, 10.1083/jcb.200612129
Itoh, 2004, Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells, EMBO J., 23, 541, 10.1038/sj.emboj.7600065
Fu, 2009, Differential regulation of transforming growth factor β signaling pathways by Notch in human endothelial cells, J. Biol. Chem., 284, 19452, 10.1074/jbc.M109.011833
Bauditz, 2004, Thalidomide for treatment of severe intestinal bleeding, Gut, 53, 609, 10.1136/gut.2003.029710
Bauditz, 2007, Angiogenesis and vascular malformations: antiangiogenic drugs for treatment of gastrointestinal bleeding, World J. Gastroenterol., 13, 5979, 10.3748/wjg.13.5979
Bose, 2009, Bevacizumab in hereditary hemorrhagic telangiectasia, N. Engl. J. Med., 360, 2143, 10.1056/NEJMc0901421
Cunha, 2010, Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis, J. Exp. Med., 207, 85, 10.1084/jem.20091309
Hawinkels, 2010, MMP-14 (MT1-MMP) mediated endoglin shedding regulates tumor angiogenesis, Canc. Res., 70, 4141, 10.1158/0008-5472.CAN-09-4466
Pardali, 2009, Transforming growth factor-β signaling and tumor angiogenesis, Front. Biosci., 14, 4848, 10.2741/3573
Goumans, 2002, Balancing the activation state of the endothelium via two distinct TGF-β type I receptors, EMBO J., 21, 1743, 10.1093/emboj/21.7.1743
Pepper, 1997, Transforming growth factor-β: vasculogenesis, angiogenesis, and vessel wall integrity, Cytokine Growth Factor Rev., 8, 21, 10.1016/S1359-6101(96)00048-2
Serrati, 2009, TGFβ1 antagonistic peptides inhibit TGFβ1-dependent angiogenesis, Biochem. Pharmacol., 77, 813, 10.1016/j.bcp.2008.10.036
Ferrari, 2006, VEGF, a prosurvival factor, acts in concert with TGF-β1 to induce endothelial cell apoptosis, Proc. Natl. Acad. Sci. U. S. A., 103, 17260, 10.1073/pnas.0605556103
Ferrari, 2009, Transforming growth factor-β1 (TGF-β1) induces angiogenesis through vascular endothelial growth factor (VEGF)-mediated apoptosis, J. Cell Physiol., 219, 449, 10.1002/jcp.21706
James, 2010, Expansion and maintenance of human embryonic stem cell-derived endothelial cells by TGFβ inhibition is Id1 dependent, Nat. Biotechnol., 28, 161, 10.1038/nbt.1605
Watabe, 2003, TGF-β receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells, J. Cell Biol., 163, 1303, 10.1083/jcb.200305147
Liu, 2009, VEGF and inhibitors of TGFβ type-I receptor kinase synergistically promote blood-vessel formation by inducing α5-integrin expression, J. Cell Sci., 122, 3294, 10.1242/jcs.048942
Goumans, 2003, Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFβ /ALK5 signaling, Mol. Cell, 12, 817, 10.1016/S1097-2765(03)00386-1
Finnson, 2008, ALK1 opposes ALK5/Smad3 signaling and expression of extracellular matrix components in human chondrocytes, J. Bone Miner. Res., 23, 896, 10.1359/jbmr.080209
Konig, 2005, TGF-β1 activates two distinct type I receptors in neurons: implications for neuronal NF-κB signaling, J. Cell Biol., 168, 1077, 10.1083/jcb.200407027
Wiercinska, 2006, Id1 is a critical mediator in TGF-βeta-induced transdifferentiation of rat hepatic stellate cells, Hepatology, 43, 1032, 10.1002/hep.21135
Daly, 2008, Transforming growth factor β-induced Smad1/5 phosphorylation in epithelial cells is mediated by novel receptor complexes and is essential for anchorage-independent growth, Mol. Cell Biol., 28, 6889, 10.1128/MCB.01192-08
Liu, 2009, TGFβ -stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFβ switch, EMBO J., 28, 88, 10.1038/emboj.2008.266
Wrighton, 2009, Transforming growth factor β can stimulate Smad1 phosphorylation independently of bone morphogenic protein receptors, J. Biol. Chem., 284, 9755, 10.1074/jbc.M809223200
Lamouille, 2002, Activin receptor-like kinase 1 is implicated in the maturation phase of angiogenesis, Blood, 100, 4495, 10.1182/blood.V100.13.4495
David, 2007, Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells, Blood, 109, 1953, 10.1182/blood-2006-07-034124
Scharpfenecker, 2007, BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis, J. Cell Sci., 120, 964, 10.1242/jcs.002949
Upton, 2009, Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells, J. Biol. Chem., 284, 15794, 10.1074/jbc.M109.002881
Shao, 2009, Expression of vascular endothelial growth factor is coordinately regulated by the activin-like kinase receptors 1 and 5 in endothelial cells, Blood, 114, 2197, 10.1182/blood-2009-01-199166
Sadick, 2005, Patients with hereditary hemorrhagic telangiectasia have increased plasma levels of vascular endothelial growth factor and transforming growth factor-β1 as well as high ALK1 tissue expression, Haematologica, 90, 818
Sadick, 2005, Plasma level and tissue expression of angiogenic factors in patients with hereditary hemorrhagic telangiectasia, Int. J. Mol. Med., 15, 591
Mitchell, 2010, ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth, Mol. Cancer Ther., 9, 379, 10.1158/1535-7163.MCT-09-0650
Suzuki, 2010, BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo, J. Cell Sci., 123, 1684, 10.1242/jcs.061556
Velasco, 2008, L- and S-endoglin differentially modulate TGFβ1 signaling mediated by ALK1 and ALK5 in L6E9 myoblasts, J. Cell Sci., 121, 913, 10.1242/jcs.023283
Ray, 2010, ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1/5/8 signaling and endothelial cell migration, Carcinogenesis, 31, 435, 10.1093/carcin/bgp327
Mahmoud, 2009, Endoglin and activin receptor-like-kinase 1 are co-expressed in the distal vessels of the lung: implications for two familial vascular dysplasias, HHT and PAH. Lab. Invest., 89, 15, 10.1038/labinvest.2008.112
David, 2009, Emerging role of bone morphogenetic proteins in angiogenesis, Cytokine Growth Factor Rev., 20, 203, 10.1016/j.cytogfr.2009.05.001
Suzuki, 2008, BMPs promote proliferation and migration of endothelial cells via stimulation of VEGF-A/VEGFR2 and angiopoietin-1/Tie2 signalling, J. Biochem., 143, 199, 10.1093/jb/mvm215
Ren, 2007, Gene expression profiles identify a role for cyclooxygenase 2-dependent prostanoid generation in BMP6-induced angiogenic responses, Blood, 109, 2847, 10.1182/blood-2006-08-039743
Valdimarsdottir, 2002, Stimulation of Id1 expression by bone morphogenetic protein is sufficient and necessary for bone morphogenetic protein-induced activation of endothelial cells, Circulation, 106, 2263, 10.1161/01.CIR.0000033830.36431.46
Pi, 2007, Sequential roles for myosin-X in BMP6-dependent filopodial extension, migration, and activation of BMP receptors, Cell Biol., 179, 1569, 10.1083/jcb.200704010
Seay, 2005, Transforming growth factor-β-dependent growth inhibition in primary vascular smooth muscle cells is p38-dependent, J. Pharmacol. Exp. Ther., 315, 1005, 10.1124/jpet.105.091249
Hirschi, 1998, PDGF, TGF-β, and heterotypic cell-cell interactions mediate endothelial cell-induced recruitment of 10T1/2 cells and their differentiation to a smooth muscle fate, J. Cell Biol., 141, 805, 10.1083/jcb.141.3.805
Wurdak, 2005, Inactivation of TGFβ signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome, Genes Dev., 19, 530, 10.1101/gad.317405
Johnson, 1996, Mutations in the activin receptor-like kinase 1 gene in hereditary hemorrhagic telangiectasia type 2, Nat. Genet., 13, 189, 10.1038/ng0696-189
McAllister, 1994, Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary hemorrhagic telangiectasia type 1, Nat. Genet., 8, 345, 10.1038/ng1294-345
Bot, 2009, Increased expression of the transforming growth factor-β signaling pathway, endoglin, and early growth response-1 in stable plaques, Stroke, 40, 439, 10.1161/STROKEAHA.108.522284
Lebrin, 2010, Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia, Nat. Med., 16, 420, 10.1038/nm.2131
Dorai, 2001, Bone morphogenetic protein-7 modulates genes that maintain the vascular smooth muscle cell phenotype in culture, J. Bone Joint Surg. Am., 83, S70, 10.2106/00004623-200100001-00010
Nakaoka, 1997, Inhibition of rat vascular smooth muscle proliferation in vitro and in vivo by bone morphogenetic protein-2, J. Clin. Invest, 100, 2824, 10.1172/JCI119830
Yu, 2005, Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells, J. Biol. Chem., 280, 24443, 10.1074/jbc.M502825200
Yu, 2008, Bone morphogenetic protein (BMP) type II receptor is required for BMP-mediated growth arrest and differentiation in pulmonary artery smooth muscle cells, J. Biol. Chem., 283, 3877, 10.1074/jbc.M706797200
Harrison, 2003, Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary hemorrhagic telangiectasia, J. Med. Genet., 40, 865, 10.1136/jmg.40.12.865
Trembath, 2001, Mutations in the TGF-β type 1 receptor, ALK1, in combined primary pulmonary hypertension and hereditary hemorrhagic telangiectasia, implies pathway specificity, J. Heart Lung Transplant, 20, 175, 10.1016/S1053-2498(00)00352-1
Thomas, 2009, Activin-like kinase 5 (ALK5) mediates abnormal proliferation of vascular smooth muscle cells from patients with familial pulmonary arterial hypertension and is involved in the progression of experimental pulmonary arterial hypertension induced by monocrotaline, Am. J. Pathol., 174, 380, 10.2353/ajpath.2009.080565
Bergers, 2008, Modes of resistance to anti-angiogenic therapy, Nat. Rev. Cancer, 8, 592, 10.1038/nrc2442
Petersen, 2010, Smad2 and Smad3 have opposing roles in breast cancer bone metastasis by differentially affecting tumor angiogenesis, Oncogene, 29, 1351, 10.1038/onc.2009.426
Roffe, 2010, Halofuginone inhibits Smad3 phosphorylation via the PI3K/Akt and MAPK/ERK pathways in muscle cells: Effects on myotube fusion, Exp. Cell Res., 316, 1061, 10.1016/j.yexcr.2010.01.003
North, M.A et al. Amgen Fremont Inc and Pfizer Inc. Human monoclonal antibodies to Activin receptor-like kinase 1, WO/2007/040912
Grinberg, A. et al. Acceleron Pharma, Inc and Ludwig Institute for Cancer Research Ltd. Methods and compositions based on ALK1 antagonists for modulating angiogenesis and pericyte coverage, WO/2009/134428
Seehra, J. et al. (2009) Acceleron Pharma, Inc. Antagonists of BMP9, BMP10, ALK1 and other ALK1 ligands, and uses therof, WO/2009/139891