Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization
Tài liệu tham khảo
Baluk, 2005, Cellular abnormalities of blood vessels as targets in cancer, Curr. Opin. Genet. Dev., 15, 102, 10.1016/j.gde.2004.12.005
Bergers, 2008, Modes of resistance to anti-angiogenic therapy, Nat. Rev. Cancer, 8, 592, 10.1038/nrc2442
Carmeliet, 1999, Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis, Cell, 98, 147, 10.1016/S0092-8674(00)81010-7
Couvelard, 2008, Overexpression of the oxygen sensors PHD-1, PHD-2, PHD-3, and FIH Is associated with tumor aggressiveness in pancreatic endocrine tumors, Clin. Cancer Res., 14, 6634, 10.1158/1078-0432.CCR-07-5258
Dutta, 2008, Activation of the VEGFR1 chromatin domain: An angiogenic signal-ETS1/HIF-2alpha regulatory axis, J. Biol. Chem., 283, 25404, 10.1074/jbc.M804349200
Epstein, 2001, C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation, Cell, 107, 43, 10.1016/S0092-8674(01)00507-4
Fischer, 2007, Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels, Cell, 131, 463, 10.1016/j.cell.2007.08.038
Gerhardt, 2008, Pericytes: gatekeepers in tumour cell metastasis?, J. Mol. Med., 86, 135, 10.1007/s00109-007-0258-2
Gerhardt, 2003, VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia, J. Cell Biol., 161, 1163, 10.1083/jcb.200302047
Grazia Lampugnani, 2003, Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148, J. Cell Biol., 161, 793, 10.1083/jcb.200209019
Greenberg, 2008, A role for VEGF as a negative regulator of pericyte function and vessel maturation, Nature, 456, 809, 10.1038/nature07424
Hamzah, 2008, Vascular normalization in Rgs5-deficient tumours promotes immune destruction, Nature, 453, 410, 10.1038/nature06868
Hellstrom, 2007, Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis, Nature, 445, 776, 10.1038/nature05571
Jain, 2005, Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy, Science, 307, 58, 10.1126/science.1104819
Jones, 2008, Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability, Nat. Med., 14, 448, 10.1038/nm1742
Kaelin, 2008, Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway, Mol. Cell, 30, 393, 10.1016/j.molcel.2008.04.009
Kappas, 2008, The VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching, J. Cell Biol., 181, 847, 10.1083/jcb.200709114
Kashiwagi, 2008, Perivascular nitric oxide gradients normalize tumor vasculature, Nat. Med., 14, 255, 10.1038/nm1730
Kearney, 2004, The VEGF receptor flt-1 (VEGFR-1) is a positive modulator of vascular sprout formation and branching morphogenesis, Blood, 103, 4527, 10.1182/blood-2003-07-2315
Kitamura, 2008, Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin, Nat. Cell Biol., 10, 329, 10.1038/ncb1695
Kuhlencordt, 2004, Role of endothelial nitric oxide synthase in endothelial activation: insights from eNOS knockout endothelial cells, Am. J. Physiol. Cell Physiol., 286, C1195, 10.1152/ajpcell.00546.2002
Le Bras, 2007, HIF-2alpha specifically activates the VE-cadherin promoter independently of hypoxia and in synergy with Ets-1 through two essential ETS-binding sites, Oncogene, 26, 7480, 10.1038/sj.onc.1210566
Lee, 2008, The biphasic role of the hypoxia-inducible factor prolyl-4-hydroxylase, PHD2, in modulating tumor-forming potential, Mol. Cancer Res., 6, 829, 10.1158/1541-7786.MCR-07-2113
Lofstedt, 2007, Hypoxia inducible factor-2alpha in cancer, Cell Cycle, 6, 919, 10.4161/cc.6.8.4133
Marxsen, 2004, Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases, Biochem. J., 381, 761, 10.1042/BJ20040620
Milkiewicz, 2004, Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice, J. Physiol., 560, 21, 10.1113/jphysiol.2004.069757
Minamishima, 2008, Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure, Blood, 111, 3236, 10.1182/blood-2007-10-117812
Nangaku, 2007, A novel class of prolyl hydroxylase inhibitors induces angiogenesis and exerts organ protection against ischemia, Arterioscler. Thromb. Vasc. Biol., 27, 2548, 10.1161/ATVBAHA.107.148551
Peng, 2000, The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling, Proc. Natl. Acad. Sci. USA, 97, 8386, 10.1073/pnas.140087397
Pospisilik, 2007, Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes, Cell, 131, 476, 10.1016/j.cell.2007.08.047
Semenza, 2003, Targeting HIF-1 for cancer therapy, Nat. Rev. Cancer, 3, 721, 10.1038/nrc1187
Stockmann, 2008, Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis, Nature, 456, 814, 10.1038/nature07445
Sullivan, 2007, Hypoxia-driven selection of the metastatic phenotype, Cancer Metastasis Rev., 26, 319, 10.1007/s10555-007-9062-2
Taddei, 2008, Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5, Nat. Cell Biol., 10, 923, 10.1038/ncb1752
Takeda, 2007, Prolyl hydroxylase domain 2 protein suppresses hypoxia-induced endothelial cell proliferation, Hypertension, 49, 178, 10.1161/01.HYP.0000251360.40838.0f
Takeda, 2007, Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system, Circulation, 116, 774, 10.1161/CIRCULATIONAHA.107.701516
Takeda, 2008, Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins, Blood, 111, 3229, 10.1182/blood-2007-09-114561
Thurston, 2007, The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth, Nat. Rev. Cancer, 7, 327, 10.1038/nrc2130
Winkler, 2004, Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases, Cancer Cell, 6, 553
Wu, 2008, Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene, Mol. Ther., 16, 1227, 10.1038/mt.2008.90
Yamashita, 2008, Hypoxia-inducible transcription factor-2alpha in endothelial cells regulates tumor neovascularization through activation of ephrin A1, J. Biol. Chem., 283, 18926, 10.1074/jbc.M709133200