Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

Cell - Tập 136 - Trang 839-851 - 2009
Massimiliano Mazzone1,2, Daniela Dettori1,2,3, Rodrigo Leite de Oliveira1,2, Sonja Loges1,2, Thomas Schmidt1,2, Bart Jonckx1,2, Ya-Min Tian4, Anthony A. Lanahan5, Patrick Pollard4, Carmen Ruiz de Almodovar1,2, Frederik De Smet1,2, Stefan Vinckier1,2, Julián Aragonés1,2, Koen Debackere1,2, Aernout Luttun6, Sabine Wyns1,2, Benedicte Jordan7, Alberto Pisacane8, Bernard Gallez7, Maria Grazia Lampugnani9
1Vesalius Research Center, VIB-Vlaams Instituut voor Biotechnologie, 3000 Leuven, Belgium
2Vesalius Research Center, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
3Laboratory of Cancer Genetics, Institute for Cancer Research and Treatment, University of Turin Medical School, 10060 Candiolo, Turin, Italy
4The Henry Wellcome Building of Genomic Medicine, Oxford OX3 7BN, UK
5Cardiovascular Medicine, Yale University, New Haven, CT 06510, USA
6Center for Molecular and Vascular Biology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
7Biomedical Magnetic Resonance Unit, Medicinal Chemistry and Radiopharmacy U.C. Louvain, 1000 Brussels, Belgium
8Unit of Pathological Anatomy, Institute for Cancer Research and Treatment, 10060 Candiolo, Turin, Italy
9Vascular Biology Unit, Italian Foundation for Cancer Research Institute of Molecular Oncology, 20139 Milan, Italy

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