Targeting the ANG2/TIE2 Axis Inhibits Tumor Growth and Metastasis by Impairing Angiogenesis and Disabling Rebounds of Proangiogenic Myeloid Cells

Cancer Cell - Tập 19 - Trang 512-526 - 2011
Roberta Mazzieri1,2, Ferdinando Pucci1,2,3, Davide Moi1,2, Erika Zonari1,2, Anna Ranghetti1,2, Alvise Berti3, Letterio S. Politi4, Bernhard Gentner2,3, Jeffrey L. Brown5, Luigi Naldini1,2,3, Michele De Palma1,2
1Angiogenesis and Tumor Targeting Research Unit, San Raffaele Scientific Institute, 20132 Milan, Italy
2San Raffaele-Telethon Institute for Gene Therapy (HSR-TIGET), Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, 20132 Milan, Italy
3Vita-Salute San Raffaele University Medical School, 20132 Milan, Italy
4Neuroradiology Department, San Raffaele Hospital, 20132 Milan, Italy
5AstraZeneca Pharmaceuticals, Waltham, MA 02451, USA

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