Activity‐based costs of blood transfusions in surgical patients at four hospitals Tập 50 Số 4 - Trang 753-765 - 2010
Aryeh Shander, Axel Hofmann, Sherri Ozawa, Oliver M. Theusinger, H. Gombotz, Donat R. Spahn
BACKGROUND: Blood utilization has long been suspected to consume more health
care resources than previously reported. Incomplete accounting for blood costs
has the potential to misdirect programmatic decision making by health care
systems. Determining the cost of supplying patients with blood transfusions
requires an in‐depth examination of the complex array of activities surrounding
the decision ... hiện toàn bộ
Orthopedic Surgery Transfusion Hemoglobin European Overview (OSTHEO) study: blood management in elective knee and hip arthroplasty in Europe* Tập 43 Số 4 - Trang 459-469 - 2003
Nadia Rosencher, H. E. M. Kerkkamp, George A. Macheras, L. Munuera, G Menichella, David M. Barton, Saskia Cremers, Ivo Abraham, For The OSTHEO Investigation
BACKGROUND: The purpose of this study was to assess current practices in blood
management in elective orthopedic surgery in Europe. STUDY DESIGN AND METHODS:
For this 225‐center prospective survey, data were collected on 3996 patients.
Actual perioperative blood loss was compared to preoperative estimates.
Differences in Hb levels and other outcome variables for patients receiving
allogeneic versu... hiện toàn bộ
ABO blood group determines plasma von Willebrand factor levels: a biologic function after all? Tập 46 Số 10 - Trang 1836-1844 - 2006
P. Vincent Jenkins, James S. O’Donnell
For many years, an association between ABO histo‐blood group and risk of
thrombosis has been recognized. Blood group non‐O (A, B, and AB) individuals
have consistently been found to demonstrate increased incidence of both arterial
and venous thrombotic disease, compared to group O individuals. This increased
risk is attributable to the fact that ABO blood group influences plasma levels
of a coagul... hiện toàn bộ
A Simple Hemagglutination System Requiring Small Amounts of Red Cells and Antibodies Tập 6 Số 1 - Trang 67-73 - 1966
Thomas Wegmann, Oliver Smithies
A method is described which permits dilute red cell suspensions (1/32%) to be
used in plastic microtiter plates for detecting hemagglutinins at unusually high
dilutions. The use of suitable additives to the hemagglutination mixture enables
excellent settling patterns and a high sensitivity to be obtained. Direct
agglutination, inhibition, enzyme promoted agglutination, and Coombs tests can
all be ... hiện toàn bộ
Mesenchymal stem or stromal cells: a review of clinical applications and manufacturing practices Tập 54 Số 5 - Trang 1418-1437 - 2014
Ratti Ram Sharma, Kathryn Pollock, Allison Hubel, David H. McKenna
Mesenchymal stem cells (MSCs) have recently generated great interest in the
fields of regenerative medicine and immunotherapy due to their unique biologic
properties. In this review we attempt to provide an overview of the current
clinical status of MSC therapy, primarily focusing on immunomodulatory and
regenerative or tissue repair applications of MSCs. In addition, current
manufacturing is revi... hiện toàn bộ
Improved outcomes and reduced costs associated with a health‐system–wide patient blood management program: a retrospective observational study in four major adult tertiary‐care hospitals Tập 57 Số 6 - Trang 1347-1358 - 2017
Michael F. Leahy, Axel Hofmann, Simon Towler, Kevin M. Trentino, Sally Burrows, Stuart G. Swain, Jeffrey M. Hamdorf, Trudi Gallagher, Audrey Koay, Gary C. Geelhoed, Shannon Farmer
BACKGROUNDPatient blood management (PBM) programs are associated with improved
patient outcomes, reduced transfusions and costs. In 2008, the Western Australia
Department of Health initiated a comprehensive health‐system–wide PBM program.
This study assesses program outcomes.STUDY DESIGN AND METHODSThis was a
retrospective study of 605,046 patients admitted to four major adult
tertiary‐care hospit... hiện toàn bộ
Detection of three types of hepatitis C virus in blood donors: investigation of type‐specific differences in serologic reactivity and rate of alanine aminotransferase abnormalities Tập 33 Số 1 - Trang 7-13 - 1993
F. McOmish, Shiu‐Wan Chan, B. C. Dow, J. Gillon, W.D. Frame, Robert J. Crawford, P. L. Yap, E. A. C. Follett, Peter Simmonds
The serologic reactivity and epidemiology associated with different hepatitis C
virus (HCV) variants were investigated in a cohort of 113 anti‐HCV‐positive
donors. In Scotland, HCV type 1 accounted for one‐ half of all infections; 40
percent of subjects were infected with HCV type 3, and the remainder were
infected with type 2. Reactivity with the NS‐4‐encoded antigens in the
first‐generation anti... hiện toàn bộ
An update on red blood cell storage lesions, as gleaned through biochemistry and omics technologies Tập 55 Số 1 - Trang 205-219 - 2015
Angelo D’Alessandro, Anastasios G. Kriebardis, Sara Rinalducci, Marianna H. Antonelou, Kirk C. Hansen, Issidora S. Papassideri, Lello Zolla
Red blood cell (RBC) aging in the blood bank is characterized by the
accumulation of a significant number of biochemical and morphologic alterations.
Recent mass spectrometry and electron microscopy studies have provided novel
insights into the molecular changes underpinning the accumulation of storage
lesions toRBCsin the blood bank. Biochemical lesions include altered cation
homeostasis, reprogr... hiện toàn bộ