An update on red blood cell storage lesions, as gleaned through biochemistry and omics technologies

Transfusion - Tập 55 Số 1 - Trang 205-219 - 2015
Angelo D’Alessandro1, Anastasios G. Kriebardis2, Sara Rinalducci3, Marianna H. Antonelou4, Kirk C. Hansen1, Issidora S. Papassideri4, Lello Zolla3
1Department of Biochemistry and Molecular Genetics, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado.
2Department of Medical Laboratories, Faculty of Health and Caring Professions, Technological Educational Institute of Athens, Athens, Greece
3Department of Ecological and Biological Sciences, University of Tuscia, Viterbo, Italy
4Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Athens, Greece

Tóm tắt

Red blood cell (RBC) aging in the blood bank is characterized by the accumulation of a significant number of biochemical and morphologic alterations. Recent mass spectrometry and electron microscopy studies have provided novel insights into the molecular changes underpinning the accumulation of storage lesions toRBCsin the blood bank. Biochemical lesions include altered cation homeostasis, reprogrammed energy, and redox metabolism, which result in the impairment of enzymatic activity and progressive depletion of high‐energy phosphate compounds. These factors contribute to the progressive accumulation of oxidative stress, which in turn promotes oxidative lesions to proteins (carbonylation, fragmentation, hemoglobin glycation) and lipids (peroxidation). Biochemical lesions negatively affectRBCmorphology, which is marked by progressive membrane blebbing and vesiculation. These storage lesions contribute to the altered physiology of long‐storedRBCsand promote the rapid clearance of up to one‐fourth of long‐storedRBCsfrom the recipient's bloodstream after 24 hours from administration. While prospective clinical evidence is accumulating, from the present review it emerges that biochemical, morphologic, and omics profiles of storedRBCshave observable changes after approximately 14 days of storage. Future studies will assess whether these in vitro observations might have clinically meaningful effects.

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Transfusion

Tập 55 Số 1

205-219

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