ABO blood group determines plasma von Willebrand factor levels: a biologic function after all?
Tóm tắt
For many years, an association between ABO histo‐blood group and risk of thrombosis has been recognized. Blood group non‐O (A, B, and AB) individuals have consistently been found to demonstrate increased incidence of both arterial and venous thrombotic disease, compared to group O individuals. This increased risk is attributable to the fact that ABO blood group influences plasma levels of a coagulation glycoprotein named von Willebrand factor (VWF). VWF levels are 25 percent higher in non‐O compared to group O individuals. The mechanism by which ABO group determines plasma VWF levels has not been determined. ABO(H) carbohydrate antigenic determinants, however, are expressed on the N‐linked glycan chains of circulating plasma VWF. This review will focus on the carbohydrate structures of VWF and recent studies suggesting that subtle variations in these structures (particularly differences in ABO blood group antigen expression) may have clinically significant effects on VWF proteolysis and clearance.
Từ khóa
Tài liệu tham khảo
Yamamoto F, 2000, Molecular genetics of ABO, Vox Sang, 78, 91
Oriol R, 1992, Genetic regulation of the expression of ABH and Lewis antigens in tissues, APMIS Suppl, 27, 28
Girma JP, 1987, Structure‐function relationship of human von Willebrand factor, Blood, 70, 605, 10.1182/blood.V70.3.605.605
Denis C, 1993, Solid‐phase von Willebrand factor contains a conformationally active RGD motif that mediates endothelial cell adhesion through the alpha v beta 3 receptor, Blood, 82, 3622, 10.1182/blood.V82.12.3622.3622
Stoddart JH, 1996, Clearance of normal and type 2A von Willebrand factor in the rat, Blood, 88, 1692, 10.1182/blood.V88.5.1692.1692
Matsui T, 1992, Structures of the asparagine‐linked oligosaccharide chains of human von Willebrand factor. Occurrence of blood group A, B, and H(O) structures, J Biol Chem, 267, 8723, 10.1016/S0021-9258(19)50338-6
Matsui T, 1999, ABO blood group antigens on human plasma von Willebrand factor after ABO‐mismatched bone marrow transplantation, Blood, 94, 2895, 10.1182/blood.V94.8.2895.420a03_2895_2900
Sodetz JM, 1979, Carbohydrate composition and identification of blood group A, B, and H oligosaccharide structures on human Factor VIII/von Willebrand factor, J Biol Chem, 254, 10754, 10.1016/S0021-9258(19)86586-9
Orstavik KH, 1985, Factor VIII and factor IX in a twin population: evidence for a major effect of ABO locus on factor VIII level, Am J Hum Genet, 37, 89
McCallum CJ, 1983, Factor VIII levels and blood group antigens, Thromb Haemost, 50, 757, 10.1055/s-0038-1665305
Mohanty D, 1984, Major blood group antigens—a determinant of factor VIII levels in blood?, Thromb Haemost, 51, 414, 10.1055/s-0038-1661121
Orstavik KH, 1989, Possible effect of secretor locus on plasma concentration of factor VIII and von Willebrand factor, Blood, 73, 990, 10.1182/blood.V73.4.990.990
O’Donnell J, 2002, The relationship between plasma concentration of alpha2‐macroglobulin and ABO blood group, Thromb Haemost, 88, 167, 10.1055/s-0037-1613176
Jenkins PV, 1998, Molecular modeling of ligand and mutation sites of the type A domains of human von Willebrand factor and their relevance to von Willebrand’s disease, Blood, 91, 2032, 10.1182/blood.V91.6.2032
Kao KJ, 1980, Factor VIII/von Willebrand protein: modification of its carbohydrate causes reduced binding to platelets, J Biol Chem, 255, 10134, 10.1016/S0021-9258(19)70438-4
Feizi T, 1982, Blood group antigens and gastric cancer, Med Biol, 60, 7