Detection of three types of hepatitis C virus in blood donors: investigation of type‐specific differences in serologic reactivity and rate of alanine aminotransferase abnormalities

Transfusion - Tập 33 Số 1 - Trang 7-13 - 1993
F. McOmish1, Shiu‐Wan Chan, B. C. Dow, J. Gillon, W.D. Frame, Robert J. Crawford, P. L. Yap, E. A. C. Follett, Peter Simmonds
1Edinburgh and South East Scotland Blood Transfusion Service.

Tóm tắt

The serologic reactivity and epidemiology associated with different hepatitis C virus (HCV) variants were investigated in a cohort of 113 anti‐HCV‐positive donors. In Scotland, HCV type 1 accounted for one‐ half of all infections; 40 percent of subjects were infected with HCV type 3, and the remainder were infected with type 2. Reactivity with the NS‐4‐encoded antigens in the first‐generation anti‐c100 assay was absent in 68 percent of donors infected with types 2 and 3, as compared with 10 percent for those infected with type 1. Even when combined with surrogate marker testing, first‐generation tests would have failed to detect 12 percent of HCV‐infected blood donors. The age distribution, incidence of past infection with hepatitis B virus, and reported risk factors were similar in donors infected with types 1 and 3 (mean ages were 31.9 and 29.9; 18 and 17.5% were positive for antibody to hepatitis B core antigen; and 47 and 48% had past intravenous drug abuse). However, the distributions of alanine aminotransferase levels were significantly different in those infected with type 3 (abnormally raised in 83%) and those infected with type 1 (55% abnormal alanine aminotransferase; p < 0.05) or type 2 (60%; p < 0.01) and those who were nonviremic (8%; p < 0.0001). These data suggest that HCV type 1 is the most common HCV infection in blood donors and that infection with HCV type 3 may be associated with more severe liver disease, because of more recent infection or because of a greater inherent pathogenicity of type 3 variants.

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Tài liệu tham khảo

10.1126/science.2523562

10.1073/pnas.88.6.2451

10.1126/science.2496467

10.1056/NEJM199010183231605

Effect of screening for hepatitis C virus antibody and hepatitis B virus core antibody on incidence of post‐transfusion hepatitis., 1991, Japanese Red Cross Non‐A Non‐B Hepatitis Research Group, Lancet, 338, 1040

10.1016/0006-291X(90)90494-8

10.1099/0022-1317-72-11-2697

10.1099/0022-1317-72-9-2105

10.1007/BF00568974

10.1016/S0006-291X(05)81414-7

10.1002/hep.1840140227

10.1073/pnas.87.24.9524

10.1128/JVI.65.3.1105-1113.1991

10.1016/0140-6736(91)92265-4

10.1099/0022-1317-73-5-1131

10.1111/j.1365-2141.1992.tb04566.x

10.1111/j.1423-0410.1992.tb01202.x

10.1128/JVI.64.2.864-872.1990

10.1073/pnas.88.8.3392

10.1016/0378-1119(91)90269-H

10.1073/pnas.88.5.1711

10.1093/nar/12.1Part1.387

10.1128/JVI.64.12.5840-5850.1990

10.1099/0022-1317-73-3-673

10.1016/0168-8278(92)90128-C

Cuypers HTM, Analysis of genomic variability of hepatitis C virus, J Hepatol

10.1016/0378-1119(91)90147-4

10.1016/0140-6736(91)90578-D

10.1046/j.1537-2995.1991.31892023508.x

10.1016/0140-6736(91)90942-I

Lelie PN, Patterns of serological markers in transfusion‐transmitted hepatitis C virus infection using second generation HCV assays, J Med Virol

Vallari DS, 1992, Serological markers of posttransfusion hepatitis C viral infection, J Clin Microbiol, 30, 552, 10.1128/jcm.30.3.552-556.1992

10.1046/j.1537-2995.1991.31291142939.x

10.1001/jama.1990.03440010047028

10.1056/NEJM198911303212202

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Transfusion

Tập 33 Số 1

7-13

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