Science Signaling

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Tim-3 signaling in peripheral NK cells promotes maternal-fetal immune tolerance and alleviates pregnancy loss
Science Signaling - Tập 10 Số 498 - 2017
Yanhong Li, Jiayuan Zhang, Di Zhang, Xi Hong, Tao Yu, Songcun Wang, Yuanyuan Xu, Hailan Piao, Weijie Yin, Min Yu, Zhang Yin, Qiang Fu, Da‐Jin Li, Xing Chang, Meirong Du
A subset of natural killer cells suppresses the mother’s immune system to protect the fetus.
Function and dysfunction of two-pore channels
Science Signaling - Tập 8 Số 384 - 2015
Sandip Patel
Channels on endosomal-lysosomal membranes are appealing targets for treatment of Parkinson’s disease and Ebola infection.
mTORC1 controls lysosomal Ca 2+ release through the two-pore channel TPC2
Science Signaling - Tập 11 Số 525 - 2018
Oluseye A. Ogunbayo, Jingxian Duan, Jian Xiong, Qiaochu Wang, Xinghua Feng, Jianjie Ma, Michael X. Zhu, A. Mark Evans
The ion channel TPC2 is required for Ca 2+ mobilization from lysosomes in response to mTORC1 inhibition and to NAADP.
TRPM2 Functions as a Lysosomal Ca 2+ -Release Channel in β Cells
Science Signaling - Tập 2 Số 71 - 2009
Ingo Lange, Shinichiro Yamamoto, Santiago Partida‐Sánchez, Yasuo Mori, Andrea Fleig, Reinhold Penner
TRPM2-mediated Ca 2+ release from lysosomal stores contributes to pancreatic β cell death in response to oxidative stress.
Essential requirement for JPT2 in NAADP-evoked Ca 2+ signaling
Science Signaling - Tập 14 Số 675 - 2021
Gihan S. Gunaratne, Eugen Brailoiu, Shijun He, Ellen M. Unterwald, Sandip Patel, James T. Slama, Timothy F. Walseth, Jonathan S. Marchant
A protein that enables the activation of two-pore channels by NAADP is identified.
IRE1α prevents hepatic steatosis by processing and promoting the degradation of select microRNAs
Science Signaling - Tập 11 Số 530 - 2018
Jie‐Mei Wang, Yining Qiu, Zhao Yang, Hyun Bae Kim, Qingwen Qian, Qinghua Sun, Chunbin Zhang, Lei Yin, Deyu Fang, Sung Hong Back, Randal J. Kaufman, Ling Yang, Kezhong Zhang
A high-fat diet causes liver disease by suppressing IRE1α-regulated microRNA biogenesis.
The genetics of PKMζ and memory maintenance
Science Signaling - Tập 10 Số 505 - 2017
Todd Charlton Sacktor, Johannes Hell
Two atypical PKC isoforms can compensate for each other during short- and long-term memory.
Local Application of Neurotrophins Specifies Axons Through Inositol 1,4,5-Trisphosphate, Calcium, and Ca 2+ /Calmodulin–Dependent Protein Kinases
Science Signaling - Tập 4 Số 199 - 2011
Shinichi Nakamuta, Yasuhiro Funahashi, Takashi Namba, Nariko Arimura, Marina R. Picciotto, Hiroshi Tokumitsu, Thomas R. Soderling, Akira Sakakibara, Takaki Miyata, Hiroyuki Kamiguchi, Kozo Kaibuchi
Neurotrophins stimulate calcium signaling to promote axon specification.
Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection
Science Signaling - Tập 2 Số 100 - 2009
Alma Zernecke, Kiril Bidzhekov, Heidi Noels, Erdenechimeg Shagdarsuren, Lin Gan, Bernd Denecke, Mihail Hristov, Thomas Köppel, Maliheh Nazari-Jahantigh, Esther Lutgens, Shusheng Wang, Eric N. Olson, Andreas Schober, Christian Weber
Apoptotic endothelial cells release microRNA-containing microvesicles to modulate the responses of neighboring cells and reduce atherosclerosis in mice.
Mitophagy controls beige adipocyte maintenance through a Parkin-dependent and UCP1-independent mechanism
Science Signaling - Tập 11 Số 527 - 2018
Xiaodan Lü, Svetlana Altshuler-Keylin, Qiang Wang, Yong Chen, Carlos H. Sponton, Kenji Ikeda, Pema Maretich, Takeshi Yoneshiro, Shingo Kajimura
Parkin-mediated mitophagy reverses the browning of white adipose tissue.
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