TRPM2 Functions as a Lysosomal Ca 2+ -Release Channel in β CellsScience Signaling - Tập 2 Số 71 - 2009
Ingo Lange, Shinichiro Yamamoto, Santiago Partida‐Sánchez, Yasuo Mori, Andrea Fleig, Reinhold Penner
TRPM2-mediated Ca
2+
release from lysosomal stores contributes to pancreatic β cell death in response to oxidative stress.
Local Application of Neurotrophins Specifies Axons Through Inositol 1,4,5-Trisphosphate, Calcium, and Ca 2+ /Calmodulin–Dependent Protein KinasesScience Signaling - Tập 4 Số 199 - 2011
Shinichi Nakamuta, Yasuhiro Funahashi, Takashi Namba, Nariko Arimura, Marina R. Picciotto, Hiroshi Tokumitsu, Thomas R. Soderling, Akira Sakakibara, Takaki Miyata, Hiroyuki Kamiguchi, Kozo Kaibuchi
Neurotrophins stimulate calcium signaling to promote axon specification.
Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosisScience Signaling - Tập 9 Số 416 - 2016
Brian J. DeBosch, Monique R. Heitmeier, Allyson L. Mayer, Cassandra B. Higgins, Jan R. Crowley, Thomas E. Kraft, Maggie Chi, Elizabeth P. Newberry, Zhouji Chen, Brian N. Finck, Nicholas O. Davidson, Kevin E. Yarasheski, Paul W. Hruz, Kelle H. Moley
The disaccharide trehalose blocks glucose uptake in hepatocytes and induces autophagy that prevents fatty liver disease.
Proteomic and Functional Genomic Landscape of Receptor Tyrosine Kinase and Ras to Extracellular Signal–Regulated Kinase SignalingScience Signaling - Tập 4 Số 196 - 2011
Adam A. Friedman, George Tucker, Rohit Singh, Dong Yan, Arunachalam Vinayagam, Yanhui Hu, Richard Binari, Pengyu Hong, Xiaoyun Sun, Maura Porto, Svetlana Pacifico, Thilakam Murali, Russell L. Finley, John M. Asara, Bonnie Berger, Norbert Perrimon
Interactome mapping and functional genomics in
Drosophila
reveal common and specific components of a mitogen-activated protein kinase pathway.
Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt–β-catenin–mediated intestinal tumor growth and regenerationScience Signaling - Tập 7 Số 345 - 2014
Toby J. Phesse, Michael Büchert, Emma Stuart, Dustin J. Flanagan, Maree C. Faux, Shoukat Afshar‐Sterle, Francesca Walker, Huihua Zhang, Cameron J. Nowell, Robert N. Jorissen, Chin Wee Tan, Yumiko Hirokawa, Moritz F. Eissmann, Christopher G. Love, Jordane Malaterre, Helen Pearson, David G. Kirsch, Paolo Provero, Valeria Poli, Robert G. Ramsay, Oliver M. Sieber, Antony W. Burgess, Dennis Huszar, Elizabeth Vincan, Matthias Ernst
Partial suppression of the inflammatory gp130-Jak-Stat pathway inhibits intestinal tumor growth.