TRPM2 Functions as a Lysosomal Ca 2+ -Release Channel in β Cells

Science Signaling - Tập 2 Số 71 - 2009
Ingo Lange1, Shinichiro Yamamoto2, Santiago Partida‐Sánchez3,4, Yasuo Mori2, Andrea Fleig1, Reinhold Penner1
1John A. Burns School of Medicine at the University of Hawaii, Honolulu, HI 96813, USA.
2Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan,
3The Ohio State University College of Medicine, Columbus, OH 43205, USA.
4The Research Institute at Nationwide Children’s Hospital, Columbus, OH 43205, USA

Tóm tắt

TRPM2-mediated Ca 2+ release from lysosomal stores contributes to pancreatic β cell death in response to oxidative stress.

Từ khóa


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