Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection

Science Signaling - Tập 2 Số 100 - 2009
Alma Zernecke1,2, Kiril Bidzhekov1, Heidi Noels1, Erdenechimeg Shagdarsuren1, Lin Gan3, Bernd Denecke3, Mihail Hristov1, Thomas Köppel4, Maliheh Nazari-Jahantigh1, Esther Lutgens5,1, Shusheng Wang6, Eric N. Olson6, Andreas Schober1, Christian Weber5,1
1Institute of Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany.
2Rudolf-Virchow-Center–DFG Research Center for Experimental Biomedicine, University of Würzburg, 97080 Würzburg, Germany.
3Interdisciplinary Centre for Clinical Research BIOMAT, Department of Vascular Surgery, RWTH Aachen University, 52074 Aachen, Germany.
4Department of Vascular Surgery, RWTH Aachen University, 52074 Aachen, Germany.
5Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, 6200 MD Maastricht, the Netherlands.
6Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390–9148, USA.

Tóm tắt

Apoptotic endothelial cells release microRNA-containing microvesicles to modulate the responses of neighboring cells and reduce atherosclerosis in mice.

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Tài liệu tham khảo

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