IRE1α prevents hepatic steatosis by processing and promoting the degradation of select microRNAs

Science Signaling - Tập 11 Số 530 - 2018
Jie‐Mei Wang1,2, Yining Qiu1, Zhao Yang1, Hyun Bae Kim1, Qingwen Qian3, Qinghua Sun4, Chunbin Zhang1, Lei Yin5, Deyu Fang6, Sung Hong Back7, Randal J. Kaufman8, Ling Yang3, Kezhong Zhang1,9
1Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201 USA
2Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, MI 48201, USA.
3Department of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
4Division of Environmental Health Sciences, College of Public Health, Ohio State University, Columbus, OH 43210, USA
5Department of Molecular and Integrative Physiology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
6Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
7School of Biological Sciences, University of Ulsan, Ulsan 680-749, Republic of Korea
8Degenerative Diseases Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
9Department of Biochemistry, Microbiology and Immunology, Wayne State University School of Medicine, Detroit, MI, 48201, USA

Tóm tắt

A high-fat diet causes liver disease by suppressing IRE1α-regulated microRNA biogenesis.

Từ khóa


Tài liệu tham khảo

10.1146/annurev-nutr-071811-150644

10.1038/emboj.2011.52

10.1038/nature07203

10.1038/nrm2199

10.1016/j.cmet.2012.03.007

10.1016/j.cell.2010.02.034

10.1038/nature17041

10.1161/CIRCRESAHA.110.225698

10.1126/science.1129631

10.1126/science.1226191

10.1083/jcb.200903014

10.1126/science.1146361

10.1016/j.celrep.2014.09.016

10.15252/embr.201540955

10.1126/science.287.5453.664

10.1016/j.cmet.2012.09.003

10.1016/j.cmet.2012.09.004

10.1074/jbc.M116.728949

10.1152/ajpgi.00132.2015

10.1126/science.aaa0079

10.1016/S0092-8674(04)00045-5

10.1172/JCI33099

10.1161/CIRCRESAHA.107.153916

10.2337/db16-0052

10.1371/journal.pone.0011621

10.1016/S0092-8674(01)00611-0

10.1038/nature04782

10.33549/physiolres.933224

10.1016/j.tem.2013.12.001

10.1016/j.cmet.2009.02.006

10.1038/onc.2010.206

10.1111/j.1440-1746.2009.05870.x

10.1074/jbc.M114.565960

10.1093/toxsci/kft230

10.1053/j.gastro.2007.10.039

10.1016/j.cmet.2006.07.007

10.1038/nrm3270

10.1091/mbc.e06-01-0055

10.1016/j.toxlet.2012.02.017

10.1016/S0016-5085(96)70028-8

10.1016/0021-9150(87)90202-4

10.1038/nm.2512

10.4161/cc.11.6.19665

10.1016/j.exger.2014.03.002

10.1038/emboj.2013.183

10.1111/j.1572-0241.1999.01377.x

10.1055/s-2001-12925

10.1038/nprot.2007.210

10.1016/j.molcel.2010.07.013

10.2337/db17-0223

10.1096/fj.201700875R

K. Yoneyama, O. Ishibashi, R. Kawase, K. Kurose, T. Takeshita, miR-200a, miR-200b and miR-429 are onco-miRs that target the PTEN gene in endometrioid endometrial carcinoma. Anticancer Res. 35, 1401–1410 (2015).

10.18632/aging.101201

10.1016/j.amjms.2016.05.002

10.1080/15476286.2015.1109768

10.1002/hep.23100

10.1038/srep16163

10.1038/srep25272

10.1016/j.bbrc.2016.12.091

10.1042/CS20170218

10.1038/ncomms6214

10.1002/path.4781

10.1038/onc.2016.6

10.3892/mmr.2016.5206

10.1152/ajpendo.00516.2013

10.1016/j.canlet.2012.02.038

10.1073/pnas.1107052108

10.1007/s11095-011-0473-y

10.1152/ajprenal.00024.2016

10.1038/cddis.2017.15

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Tập 11 Số 530

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