mTORC1 controls lysosomal Ca 2+ release through the two-pore channel TPC2

Science Signaling - Tập 11 Số 525 - 2018
Oluseye A. Ogunbayo1, Jingxian Duan1, Jian Xiong2, Qiaochu Wang2, Xinghua Feng2, Jianjie Ma3, Michael X. Zhu2, A. Mark Evans1
1Centres for Discovery Brain Sciences and Cardiovascular Sciences, Biomedical Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, EH8 9XD Scotland, UK.
2Department of Integrative Biology and Pharmacology, McGovern Medical School, Program in Biochemistry and Cell Biology, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
3Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA.

Tóm tắt

The ion channel TPC2 is required for Ca 2+ mobilization from lysosomes in response to mTORC1 inhibition and to NAADP.

Từ khóa


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Tập 11 Số 525

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