Mitophagy controls beige adipocyte maintenance through a Parkin-dependent and UCP1-independent mechanism

Science Signaling - Tập 11 Số 527 - 2018
Xiaodan Lü1,2,3,4, Svetlana Altshuler-Keylin5,2,3, Qiang Wang2,3, Yong Chen2,3, Carlos H. Sponton2,3,6, Kenji Ikeda2,3, Pema Maretich2,3, Takeshi Yoneshiro2,3, Shingo Kajimura2,3
1Department of Immunology, Jilin University, Changchun, Jilin 130021, China.
2Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA
3Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, San Francisco, CA 94143, USA.
4Medical Diagnostic Research Center, Jilin Province People’s Hospital, Changchun, Jilin 130021, China.
5Department of Physiological Chemistry, Genentech, Inc., South San Francisco, CA 94080, USA
6Obesity and Comorbidities Research Center, University of Campinas (UNICAMP), Campinas, Sao Paulo 13084-970, Brazil.

Tóm tắt

Parkin-mediated mitophagy reverses the browning of white adipose tissue.

Từ khóa


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