Parasite Immunology
SCIE-ISI SCOPUS (1979-2023)
0141-9838
1365-3024
Anh Quốc
Cơ quản chủ quản: Wiley-Blackwell Publishing Ltd , WILEY
Lĩnh vực:
ImmunologyParasitology
Các bài báo tiêu biểu
Infection with Schistosoma mansoni prevents insulin dependent diabetes mellitus in non‐obese diabetic mice The spontaneous development of insulin dependent diabetes mellitus in non‐obese diabetic (NOD) mice has been shown to be mediated by a Th1 response against beta cell antigens. It is known that in murine models of Schistosoma mansoni infection, egg production is associated with a switch from a Th1 to Th2 response. This subsequent dominance of a Th2 r... ... hiện toàn bộ
Tập 21 Số 4 - Trang 169-176 - 1999
Immunology of canine leishmaniasisSUMMARY The role of dogs as the main reservoir of visceral leishmaniasis has led to an increased interest in the immune responses and in Leishmania antigens implicated in protective cellular immunity in canine visceral leishmaniasis. The primary goal is to control the prevalence of human disease. Immune responses in canine vi... ... hiện toàn bộ
Tập 28 Số 7 - Trang 329-337 - 2006
Cryptosporidium in humans and animals—a one health approach to prophylaxisSummary Cryptosporidium is a major cause of moderate‐to‐severe diarrhoea in humans worldwide, second only to rotavirus. Due to the wide host range and environmental persistence of this parasite, cryptosporidiosis can be zoonotic and associated with foodborne and waterborne outbreaks. Currently, 31 species are recognized as valid, and of th...
Tập 38 Số 9 - Trang 535-547 - 2016
Genetic diversity and malaria vaccine design, testing and efficacy: preventing and overcoming ‘vaccine resistant malaria’Summary The development of effective malaria vaccines may be hindered by extensive genetic diversity in the surface proteins being employed as vaccine antigens. Understanding of the extent and dynamics of genetic diversity in vaccine antigens is needed to guide rational vaccine design and to interpret the results of vaccine efficacy trials conducted in malaria endem... ... hiện toàn bộ
Tập 31 Số 9 - Trang 560-573 - 2009
Immunization against malaria with a recombinant proteinSUMMARY We have expressed in bacteria the C‐terminal part of Plasmodium yoelii merozoite surface protein‐1 (MSP1) containing the two epidermal growth factor‐like domains. The protein, either alone or fused to glutathione Stransferase, was highly effective as a vaccine and protected mice against challenge infection. Reduction and alkylation... ... hiện toàn bộ
Tập 16 Số 2 - Trang 63-67 - 1994
Immunization of mice and baboons with the recombinant Sm28GST affects both worm viability and fecundity after experimental infection with Schistosoma mansoniSummary A member of the glutathione S‐transferase family. Sm28GST has previous! demonstrated a good ability to protect rodents against experimental infection with Schistosoma mansoni. In order lo evaluate its efficacy in a model closer to man, two different protocols of immunization with recombinant Sm28GST were tested on baboons in a larg...
Tập 13 Số 5 - Trang 473-490 - 1991
TNF‐α, nitric oxide and IFN‐γ are all critical for development of necrosis in the small intestine and early mortality in genetically susceptible mice infected perorally with Toxoplasma gondii We previously reported that genetic susceptibility of mice to peroral infection with T. gondii is associated with CD4+ T cell‐dependent, interferon (IFN)‐γ‐mediated necrosis of their small intestine. We examined the role of tumour necrosis factor (TNF)‐α and nitric oxide (NO), in addition to IFN‐γ. At 7 days after infection, a m... ... hiện toàn bộ
Tập 21 Số 7 - Trang 365-376 - 1999
Ablation of eosinophils with anti‐IL‐5 antibody enhances the survival of intracranial worms of Angiostrongylus cantonensis in the mouseSummary Effects of depressed eosinophilia on the development of Angiostrongylus cantonensis in the mouse were studied using monoclonal rat anti‐mouse‐interleukin‐5 antibody (anti‐IL‐5). The administration of anti‐IL‐5 strongly depressed peripheral, cerebrospinal fluid (CSF) and medullary eosinophilic responses in mice infected with A. cantonensis, when compared with... ... hiện toàn bộ
Tập 15 Số 6 - Trang 349-354 - 1993
Immunoregulation in human lymphatic filariasis: the role of interleukin 10Summary In humans with lymphatic filariasis microfilaremia is associated with a parasite antigen‐specific hyporesponsive‐ness when assessed by cell proliferation and secretion of interleukin‐2 and interferon‐γ. Hyporesponsiveness in these individuals is not only parasite antigen‐specific but appears to be limited to Th1‐type responses. Th2 mediated responses such as... ... hiện toàn bộ
Tập 17 Số 8 - Trang 385-392 - 1995
Demonstration of Leishmania specific cell mediated and humoral immunity in asymptomatic dogsSummary An ELISA and a lymphocyte proliferation assay were used for the detection of anti‐Leishmania antibodies and parasite specific cellular immunity respectively in a preliminary study of canine leishmaniasis in Oporto, Portugal. A high rate of infection was found considering the comparatively small group sampled. Of 34 dogs examined two...
Tập 14 Số 5 - Trang 531-539 - 1992