Parasite Immunology
SCIE-ISI SCOPUS (1979-2025)
0141-9838
1365-3024
Anh Quốc
Cơ quản chủ quản: Wiley-Blackwell Publishing Ltd , WILEY
Lĩnh vực:
ImmunologyParasitology
Các bài báo tiêu biểu
Infection with Schistosoma mansoni prevents insulin dependent diabetes mellitus in non‐obese diabetic mice
Tập 21 Số 4 - Trang 169-176 - 1999
The spontaneous development of insulin dependent diabetes mellitus in non‐obese
diabetic (NOD) mice has been shown to be mediated by a Th1 response against beta
cell antigens. It is known that in murine models of Schistosoma mansoni
infection, egg production is associated with a switch from a Th1 to Th2
response. This subsequent dominance of a Th2 response in S.mansoni infected mice
has been shown...
Immunology of canine leishmaniasis
Tập 28 Số 7 - Trang 329-337 - 2006
SUMMARY The role of dogs as the main reservoir of visceral leishmaniasis has led
to an increased interest in the immune responses and in Leishmania antigens
implicated in protective cellular immunity in canine visceral leishmaniasis. The
primary goal is to control the prevalence of human disease. Immune responses in
canine visceral leishmaniasis are reviewed. Cellular immune responses toward a
Th1...
Cryptosporidium in humans and animals—a one health approach to prophylaxis
Tập 38 Số 9 - Trang 535-547 - 2016
SummaryCryptosporidium is a major cause of moderate‐to‐severe diarrhoea in
humans worldwide, second only to rotavirus. Due to the wide host range and
environmental persistence of this parasite, cryptosporidiosis can be zoonotic
and associated with foodborne and waterborne outbreaks. Currently, 31 species
are recognized as valid, and of these, Cryptosporidium hominis and
Cryptosporidium parvum are ...
Genetic diversity and malaria vaccine design, testing and efficacy: preventing and overcoming ‘vaccine resistant malaria’
Tập 31 Số 9 - Trang 560-573 - 2009
SummaryThe development of effective malaria vaccines may be hindered by
extensive genetic diversity in the surface proteins being employed as vaccine
antigens. Understanding of the extent and dynamics of genetic diversity in
vaccine antigens is needed to guide rational vaccine design and to interpret the
results of vaccine efficacy trials conducted in malaria endemic areas. Molecular
epidemiologic...
Immunization against malaria with a recombinant protein
Tập 16 Số 2 - Trang 63-67 - 1994
SUMMARYWe have expressed in bacteria the C‐terminal part of Plasmodium yoelii
merozoite surface protein‐1 (MSP1) containing the two epidermal growth
factor‐like domains. The protein, either alone or fused to glutathione
Stransferase, was highly effective as a vaccine and protected mice against
challenge infection. Reduction and alkylation abolished the protection obtained
with the protein. This sh...
Immunization of mice and baboons with the recombinant Sm28GST affects both worm viability and fecundity after experimental infection with Schistosoma mansoni
Tập 13 Số 5 - Trang 473-490 - 1991
Summary A member of the glutathione S‐transferase family. Sm28GST has previous!
demonstrated a good ability to protect rodents against experimental infection
with Schistosoma mansoni. In order lo evaluate its efficacy in a model closer to
man, two different protocols of immunization with recombinant Sm28GST were
tested on baboons in a large‐scale trial. Three injections in the presence of
aluminiu...
TNF‐α, nitric oxide and IFN‐γ are all critical for development of necrosis in the small intestine and early mortality in genetically susceptible mice infected perorally with Toxoplasma gondii
Tập 21 Số 7 - Trang 365-376 - 1999
We previously reported that genetic susceptibility of mice to peroral infection
with T. gondii is associated with CD4+ T cell‐dependent, interferon
(IFN)‐γ‐mediated necrosis of their small intestine. We examined the role of
tumour necrosis factor (TNF)‐α and nitric oxide (NO), in addition to IFN‐γ. At 7
days after infection, a marked increase in CD4+ T cells was observed in lamina
propria mononucl...
Ablation of eosinophils with anti‐IL‐5 antibody enhances the survival of intracranial worms of Angiostrongylus cantonensis in the mouse
Tập 15 Số 6 - Trang 349-354 - 1993
SummaryEffects of depressed eosinophilia on the development of Angiostrongylus
cantonensis in the mouse were studied using monoclonal rat
anti‐mouse‐interleukin‐5 antibody (anti‐IL‐5). The administration of anti‐IL‐5
strongly depressed peripheral, cerebrospinal fluid (CSF) and medullary
eosinophilic responses in mice infected with A. cantonensis, when compared with
groups treated with phosphate‐bu...
Immunoregulation in human lymphatic filariasis: the role of interleukin 10
Tập 17 Số 8 - Trang 385-392 - 1995
SummaryIn humans with lymphatic filariasis microfilaremia is associated with a
parasite antigen‐specific hyporesponsive‐ness when assessed by cell
proliferation and secretion of interleukin‐2 and interferon‐γ.
Hyporesponsiveness in these individuals is not only parasite antigen‐specific
but appears to be limited to Th1‐type responses. Th2 mediated responses such as
IL‐5 secretion and IgE antibody ...
Demonstration of Leishmania specific cell mediated and humoral immunity in asymptomatic dogs
Tập 14 Số 5 - Trang 531-539 - 1992
Summary An ELISA and a lymphocyte proliferation assay were used for the
detection of anti‐Leishmania antibodies and parasite specific cellular immunity
respectively in a preliminary study of canine leishmaniasis in Oporto, Portugal.
A high rate of infection was found considering the comparatively small group
sampled. Of 34 dogs examined two had anti‐leishmanial antibodies but their
lymphocytes did...