Parasite Immunology

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The gut mucosal immune response to Toxoplasma gondii
Parasite Immunology - Tập 37 Số 3 - Trang 108-117 - 2015
Sara Cohen, Eric Denkers
SummaryAs an orally acquired pathogen, the immune response to Toxoplasma gondii unfolds in the small intestinal mucosa. There, an array of regulatory and effector immune cells are elicited to combat the parasite through secretion of inflammatory mediators, normally resulting in host protection and pathogen control. Recent studies largely ...... hiện toàn bộ
Early treatment during a primary malaria infection modifies the development of cross immunity
Parasite Immunology - Tập 26 Số 1 - Trang 7-17 - 2004
Martha Legorreta‐Herrera, María Laura Ventura-Ayala, R. N. Licona‐Chávez, Isabel Soto‐Cruz, F. F. Hernández‐Clemente
SUMMARY We have used a murine model to study the kinetics of cross‐protection when a primary infection is halted at different times. We analysed how parasitaemia is modified during a second infection with the homologous parasite, a heterologous parasite, or a mixture of the two. In addition, possible mechanisms involved in cross‐protection were analyse...... hiện toàn bộ
Divergent expression of inflammatory dermal chemokines in cutaneous leishmaniasis*
Parasite Immunology - Tập 24 Số 6 - Trang 295-301 - 2002
Uwe Ritter, Heinrich Körner
SummaryHuman leishmaniasis is caused by protozoan Leishmania (L.) parasites and comprises a heterogeneous group of clinical appearances ranging from visceral to cutaneous leishmaniasis. In the New World, L. mexicana mediates American cutaneous leishmaniasis, one of the most common forms of this disease. Two differen...... hiện toàn bộ
Interferon‐gamma‐mediated effects upon immunity to coccidial infections in the mouse
Parasite Immunology - Tập 13 Số 1 - Trang 63-74 - 1991
Mark E. Rose, D. Wakelin, Patricia Hesketh
Summary The effect of treatment with a monoclonal antibody (MoAb) capable of neutralising interferon‐gamma (IFN‐y) on the course of coccidial infections in mice (C57BL/6 and NIH infected with Eimeria vermiformis or E. pragensis, and BALBc infected with E. pragensis) was examined. Th...... hiện toàn bộ
Induction of a protective antibody‐dependent response against toxoplasmosis by in vitro excreted/secreted antigens from tachyzoites of Toxoplasma gondii
Parasite Immunology - Tập 10 Số 5 - Trang 553-567 - 1988
F Darcy, Didier Deslée, F Santoro, H Charif, Claude Auriault, A Decoster, Véronique Duquesne, A Capron
Summary Toxoplasma gondii is a worldwide protozoan parasite which causes severe disease in congenitally infected children and in immunocompromised patients. Besides the well‐defined cytoplasmic and membrane antigens of tachyzoites, we felt that excreted/secreted antigens could play a major role in the immune response. We first report the development of a well‐co...... hiện toàn bộ
Immunoregulation in human lymphatic filariasis: the role of interleukin 10
Parasite Immunology - Tập 17 Số 8 - Trang 385-392 - 1995
Siddhartha Mahanty, Thomas B. Nutman
SummaryIn humans with lymphatic filariasis microfilaremia is associated with a parasite antigen‐specific hyporesponsive‐ness when assessed by cell proliferation and secretion of interleukin‐2 and interferon‐γ. Hyporesponsiveness in these individuals is not only parasite antigen‐specific but appears to be limited to Th1‐type responses. Th2 mediated responses such as...... hiện toàn bộ
Immune dependence of schistosomicidal chemotherapy: an ultrastructural study of Schistosoma mansoni adult worms exposed to praziquantel and immune serum in vivo
Parasite Immunology - Tập 12 Số 3 - Trang 321-334 - 1990
J Modha, José Roberto Lambertucci, M. J. Doenhoff, Diane J. McLaren
Summary This study examines the immune‐dependence of praziquantel (PZQ) for the treatment of Schistosomiasis mansoni in mice. We have shown elsewhere from worm recovery data that the efficacy of PZQ is significantly enhanced when mice are treated concomitantly with antisera raised against antigens released from adult schistosomes, even though such antisera show no in...... hiện toàn bộ
Rice‐produced MSP142 of Plasmodium falciparum elicits antibodies that inhibit parasite growth in vitro
Parasite Immunology - Tập 38 Số 10 - Trang 635-641 - 2016
Qiande Chen, Wanqi Liang, Feng Qian, Biao Qian, Jianping Cao, Dingguo Zhang, Yaobo Xu, Lin-hua Tang
SummaryMany malaria antigens contain multiple disulphide bonds involved in the formation of inhibitory B‐cell epitopes. Producing properly folded malaria antigens in sufficient quantities for vaccination is often a challenge. The 42‐kDa fragment of Plasmodium falciparum merozoi...... hiện toàn bộ
Induction of haem oxygenase‐1 increases infection of dog macrophages by L. infantum
Parasite Immunology - Tập 39 Số 12 - 2017
Breno Fernando Martins de Almeida, K. L. O. Silva, Gabriela Lovizutto Venturin, Vanessa Marin Chiku, Aline Aparecida Correa Leal, Anelise Maria Bosco, Paulo César Ciarlini, Valéria Marçal Felix de Lima
SummaryWe aimed to induce and inhibit HO‐1, ascertaining its effect on infection rate, parasite load and the levels of superoxide, reactive oxygen species (ROS), nitric oxide (NO), ...... hiện toàn bộ
Influence of genes within the MHC on mortality and brain cyst development in mice infected with Toxoplasma gondii: kinetics of immune regulation in BALB H‐2 congenic mice
Parasite Immunology - Tập 15 Số 6 - Trang 317-324 - 1993
Jenefer M. Blackwell, Craig W. Roberts, James Alexander
SummaryPrevious work has shown that genes within the major histocompatibility complex (MHC) of the mouse influence resistance and susceptibility to Toxoplasma gondii infection. Initial studies presented here using B10 H‐2 congenic and recombinant haplotype mice inoculated via the oral route with the low virulence Beverley strain of T. gondii confirm the D region lo...... hiện toàn bộ
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