Parasite Immunology

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Immunization against malaria with a recombinant protein
Parasite Immunology - Tập 16 Số 2 - Trang 63-67 - 1994
Irene T. Ling, Solabomi A. Ogun, Anthony A. Holder
SUMMARYWe have expressed in bacteria the C‐terminal part of Plasmodium yoelii merozoite surface protein‐1 (MSP1) containing the two epidermal growth factor‐like domains. The protein, either alone or fused to glutathione Stransferase, was highly effective as a vaccine and protected mice against challenge infection. Reduction and alkylation abolished the protection obtained with the protein. This sh... hiện toàn bộ
Infection with Schistosoma mansoni prevents insulin dependent diabetes mellitus in non‐obese diabetic mice
Parasite Immunology - Tập 21 Số 4 - Trang 169-176 - 1999
Anne Cooke, Paul Tonks, Frances J. Jones, Helen O’Shea, Patricia Hutchings, Anthony J. C. Fulford, David W. Dunne
The spontaneous development of insulin dependent diabetes mellitus in non‐obese diabetic (NOD) mice has been shown to be mediated by a Th1 response against beta cell antigens. It is known that in murine models of Schistosoma mansoni infection, egg production is associated with a switch from a Th1 to Th2 response. This subsequent dominance of a Th2 response in S.mansoni infected mice has been shown... hiện toàn bộ
Unique roles of Schistosoma japonicum protein Sj16 to induce IFN‐γ and IL‐10 producing CD4+CD25+ regulatory T cells in vitro and in vivo
Parasite Immunology - Tập 34 Số 8-9 - Trang 430-439 - 2012
Xi Sun, R. Li, Ying Zhou, Yang Wang, X. J. LIU, Qiao Lu, Chunlei Zhou, Zhongdao Wu
SummaryVarious proteins are expressed during different stages of schistosome development that are essential for cercarial penetration of vertebrate skin and evasion of host immune response. CD4+CD25+ regulatory T cells are important in modulating immune responses towards helminth infections. Schistosoma japonicum protein Sj16 present in the secretions of schistosomula has been shown to have anti‐i... hiện toàn bộ
Schistosomiasis delays lesion resolution during Leishmania major infection by impairing parasite killing by macrophages
Parasite Immunology - Tập 24 Số 7 - Trang 339-345 - 2002
Anne Camille La Flamme, Phillip Scott, Edward J. Pearce
Summary Infection of mice with Schistosoma mansoni delays the resolution of cutaneous lesions and parasitaemia during Leishmania major infection. In contrast, L. major infection does not appear to alter the course of schistosomiasis. Analysis of the cytokine responses in the draining lymph nodes (LN) indicates that, while L. major infection had no effect on schistosome‐specific interleukin (IL)‐4 ... hiện toàn bộ
Haemonchus contortus intestine: a prominent source of mucosal antigens
Parasite Immunology - Tập 29 Số 3 - Trang 139-151 - 2007
Douglas P. Jasmer, Kevin K. Lahmers, Wendy C. Brown
SUMMARY We sought to identify antigens from Haemonchus contortus, an abomasal nematode of small ruminants, that stimulate local (abomasal lymph node, ALN) CD4+ T lymphocyte responses during a primary infection. Results led to a focus on antigens from the parasite intestine. The H. contortus intestine proved to be a major source of antigens that stimulated ALN CD4+, CD25+ T lymphocyte responses dur... hiện toàn bộ
Protection induced by vaccinating sheep with a thiol‐binding extract ofHaemonchus contortusmembranes is associated with its protease components
Parasite Immunology - Tập 27 Số 4 - Trang 121-126 - 2005
David P. Knox, S. K. Smith, Diane L. Redmond, William D. Smith
SUMMARYPrevious work has shown that a protein extract enriched for cysteine protease activity (TSBP) prepared from adultHaemonchus contortususing thiol sepharose affinity chromatography confers substantial protection against a single challenge infection. TSBP comprised proteases and other proteins. Here, TSBP were further fractionated using anion‐exchange chromatography and fractions pooled on the... hiện toàn bộ
Protease‐activated receptor 2 contributes to Toxoplasma gondii‐mediated gut inflammation
Parasite Immunology - Tập 39 Số 11 - 2017
Chrystelle Bonnart, Guylène Feuillet, Virginie Vasseur, Nicolas Cénac, Nathalie Vergnolle, Nicolas Blanchard
SummaryToxoplasma gondii is a widespread intracellular parasite, which naturally enters the organism via the oral route and crosses the intestinal barrier to disseminate. In addition to neuronal and ocular pathologies, this pathogen also causes gut inflammation in a number of animals. This infection‐triggered inflammation has been extensively studied in the C57BL/6 mice, highlighting the importanc... hiện toàn bộ
The gut mucosal immune response to Toxoplasma gondii
Parasite Immunology - Tập 37 Số 3 - Trang 108-117 - 2015
Sara Cohen, Eric Denkers
SummaryAs an orally acquired pathogen, the immune response to Toxoplasma gondii unfolds in the small intestinal mucosa. There, an array of regulatory and effector immune cells are elicited to combat the parasite through secretion of inflammatory mediators, normally resulting in host protection and pathogen control. Recent studies largely in mice have found that a productive immune response require... hiện toàn bộ
Interactions between macrophages and helminths
Parasite Immunology - Tập 42 Số 7 - 2020
Gillian Coakley, Nicola Harris
AbstractMacrophages, the major population of tissue‐resident mononuclear phagocytes, contribute significantly to the immune response during helminth infection. Alternatively activated macrophages (AAM) are induced early in the anti‐helminth response following tissue insult and parasite recognition, amplifying the early type 2 immune cascade initiated by epithelial cells and ILC2s, and subsequently... hiện toàn bộ
Schistosoma japonicum egg granuloma formation in the interleukin‐4 or interferon‐γ deficient host
Parasite Immunology - Tập 23 Số 6 - Trang 271-280 - 2001
M. Hirata, Masayoshi Kage, Tatsuru Hara, Yutaka Yoneda, Mei Zhang, Toshihide Fukuma
The roles of interleukin (IL)‐4 and interferon (IFN)‐γ in Schistosoma japonicum egg granuloma formation were investigated in cercariae‐infected (infection model) or after implantation of laid parasite eggs (egg implantation model) in cytokine deficient mice. Two weeks after hepatic egg‐implantation, a markedly decreased mononuclear cell infiltration and lack of multinuclear cell formation were cha... hiện toàn bộ
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