Parasite Immunology

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Mimicry of snail host antigens by miracidia and primary sporocysts of Schistosoma mansoni
Parasite Immunology - Tập 5 Số 3 - Trang 317-328 - 1983
Timothy P. Yoshino, Christopher J. Bayne
Summary Polyvalent antisera generated in rabbits to soluble haemolymph components from Schistosoma /warworn‐susceptible (PR albino ‘M line’) and S. /warworn‐resistant (10‐R2) stocks of the snail Biomphalaria glabrata were employed as membrane probes to determine if antigens related to snail haemolymph were produced by the early larval stages of S. mansoni (PR‐1 strai...... hiện toàn bộ
Immunization against malaria with a recombinant protein
Parasite Immunology - Tập 16 Số 2 - Trang 63-67 - 1994
Irene T. Ling, Solabomi A. Ogun, Anthony A. Holder
SUMMARYWe have expressed in bacteria the C‐terminal part of Plasmodium yoelii merozoite surface protein‐1 (MSP1) containing the two epidermal growth factor‐like domains. The protein, either alone or fused to glutathione Stransferase, was highly effective as a vaccine and protected mice against challenge infection. Reduction and alkylation...... hiện toàn bộ
Relationship between parasite‐specific antibody responses and intensity of Opisthorchis viverrini infection in hamsters
Parasite Immunology - Tập 22 Số 3 - Trang 139-145 - 2000
Banchob Sripa, Sasithorn Kaewkes
The kinetics of parasite‐specific antibody responses in relation to worm burden and egg output were investigated in hamsters infected with 25, 50 and 100 Opisthorchis viverrini metacercariae (MC). Levels of antibody to egg, excretory–secretory (ES) and somatic antigens were examined by ELISA on days 1, 3, 7, 14 and month 1 postinfection (p.i.), and ...... hiện toàn bộ
Immunological genomics of Brugia malayi: filarial genes implicated in immune evasion and protective immunity
Parasite Immunology - Tập 23 Số 7 - Trang 327-344 - 2001
Rick M. Maizels, Mark Blaxter, Alan L. Scott
Filarial nematodes are metazoan parasites with genome sizes openface>  100 million base pairs, probably encoding 15 000‐20 000 genes. Within this considerable gene complement, it seems likely that filariae have evolved a spectrum of immune evasion products which underpin their ability to live for many years within the human host. Moreover, no suitable vaccine currently exists for human ...... hiện toàn bộ
Interactions between macrophages and helminths
Parasite Immunology - Tập 42 Số 7 - 2020
Gillian Coakley, Nicola Harris
AbstractMacrophages, the major population of tissue‐resident mononuclear phagocytes, contribute significantly to the immune response during helminth infection. Alternatively activated macrophages (AAM) are induced early in the anti‐helminth response following tissue insult and parasite recognition, amplifying the early type 2 immune cascade initiated by epithelial ...... hiện toàn bộ
Schistosoma japonicum egg granuloma formation in the interleukin‐4 or interferon‐γ deficient host
Parasite Immunology - Tập 23 Số 6 - Trang 271-280 - 2001
M. Hirata, Masayoshi Kage, Tatsuru Hara, Yutaka Yoneda, Mei Zhang, Toshihide Fukuma
The roles of interleukin (IL)‐4 and interferon (IFN)‐γ in Schistosoma japonicum egg granuloma formation were investigated in cercariae‐infected (infection model) or after implantation of laid parasite eggs (egg implantation model) in cytokine deficient mice. Two weeks after hepatic egg‐implantation, a markedly decreased mononuclear cell infiltration and lack of m...... hiện toàn bộ
T‐cell‐dependent eosinophilia in the cerebrospinal fluid of the mouse infected with Angiostrongylus cantonensis
Parasite Immunology - Tập 10 Số 2 - Trang 127-138 - 1988
Hiroko Sugaya, Kentaro Yoshimura
Summary Eosinophilia of the cerebrospinai fluid (CSF) in permissive (rats) and non‐permissive (mice) hosts infected with Angiostrongylus cantonensis, and the possible mechanism of the eosinophilia were studied. In three strains of thymic mice (ICR, ddY and BALB/c), the infection provoked a marked CSF eosinophilia starting at around day...... hiện toàn bộ
Ultrastructural and morphometric analyses of eosinophils from the cerebrospinal fluid of the mouse and guinea‐pig infected with Angiostrongylus cantonensis
Parasite Immunology - Tập 10 Số 4 - Trang 411-423 - 1988
Kentaro Yoshimura, Hiroko Sugaya, Koichi Kawamura, Masahiro Kumagai
Summary Guinea‐pigs infected with Angiostrongylus cantonensis developed pleocytosis and eosinophilia in the cerebrospinal fluid (CSF) at day 12 post‐infection (p.i.). showing a peak response at day 20 p.i., followed by a gradual reduction. Ultrastructural observations on CSF eosinophils from infected mice and guinea‐pigs revealed vario...... hiện toàn bộ
Ablation of eosinophils with anti‐IL‐5 antibody enhances the survival of intracranial worms of Angiostrongylus cantonensis in the mouse
Parasite Immunology - Tập 15 Số 6 - Trang 349-354 - 1993
Osamu Sasaki, Hiroko Sugaya, Kazuto Ishida, Kentaro Yoshimura
SummaryEffects of depressed eosinophilia on the development of Angiostrongylus cantonensis in the mouse were studied using monoclonal rat anti‐mouse‐interleukin‐5 antibody (anti‐IL‐5). The administration of anti‐IL‐5 strongly depressed peripheral, cerebrospinal fluid (CSF) and medullary eosinophilic responses in mice infected with A. cantonensis, when compared with...... hiện toàn bộ
Ultrastructural evidence for eosinophil‐mediated destruction of Angiostrongylus cantonensis transferred into the pulmonary artery of non‐permissive hosts
Parasite Immunology - Tập 6 Số 2 - Trang 105-118 - 1984
Kazuya Yoshimura, Kikue Uchida, Keiko Sato, Hiroshi Oya
Summary Ultrastructural and cytochemical analyses were carried out on cellular reactions to the young adult worms of Angiostrongylus cantonensis surgically transferred into the pulmonary arteries of permissive (rat) and non‐permissive (rabbit and guinea‐pig) hosts. In permissive hosts, no appreciable cellular reactions could be found around...... hiện toàn bộ
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