Early treatment during a primary malaria infection modifies the development of cross immunity

Parasite Immunology - Tập 26 Số 1 - Trang 7-17 - 2004
Martha Legorreta‐Herrera1, María Laura Ventura-Ayala1, R. N. Licona‐Chávez1, Isabel Soto‐Cruz1, F. F. Hernández‐Clemente1
1Laboratorio de Immunología Molecular, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónomia de Mexico, Iztapalapa, Mexico

Tóm tắt

SUMMARY We have used a murine model to study the kinetics of cross‐protection when a primary infection is halted at different times. We analysed how parasitaemia is modified during a second infection with the homologous parasite, a heterologous parasite, or a mixture of the two. In addition, possible mechanisms involved in cross‐protection were analysed. Results show that treatment with pyrimethamine on day 5 during a primary infection with P. chabaudi AS (non‐lethal), prevents the generation of cross‐protection to a new challenge with lethal P. yoelii 17XL. In contrast, when treatment is on day 7, mice survive a P. yoelii infection. Differences between both groups suggest that in order for ‘preimmune’ mice to survive a lethal challenge, a predominantly TH2‐type response is required, with a higher mRNA expression level of IL‐4 and IL‐10, and a lower mRNA expression of IFN‐γ. This work shows that an early treatment of a malaria infection produced by a non‐lethal parasite drives the immune response towards a loss of cross‐protection to further infections, in particular with more virulent parasites. This finding should be taken into account for the development of effective malaria vaccines.

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Parasite Immunology

Tập 26 Số 1

7-17

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