Immunology of canine leishmaniasis

Parasite Immunology - Tập 28 Số 7 - Trang 329-337 - 2006
C. Barbieri1
1Department of Immunology, Microbiology and Parasitology, Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brazil

Tóm tắt

SUMMARY The role of dogs as the main reservoir of visceral leishmaniasis has led to an increased interest in the immune responses and in Leishmania antigens implicated in protective cellular immunity in canine visceral leishmaniasis. The primary goal is to control the prevalence of human disease. Immune responses in canine visceral leishmaniasis are reviewed. Cellular immune responses toward a Th1 subset mediated by IFN‐γ and TNF‐α predominate in asymptomatic dogs exhibiting apparent resistance to visceral leishmaniasis. On the other hand, while the role of Th2 cytokines, such as IL‐4 and IL‐10, in symptomatic animals is still controversial, there is increasing evidence for a correlation of these cytokines with progressive disease. CD8+ cytotoxic T cells seem also likely to be involved in resistance to visceral leishmaniasis. Several Leishmania antigens implicated in protective immune responses are described and some pivotal points for development of an effective vaccine against canine visceral leishmaniasis are discussed.

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Tài liệu tham khảo

10.1051/parasite/1990653111

10.1016/S0169-4758(00)01637-9

World Health Organization., 1999, Tropical Disease Research Progress 1997–1998., 1

10.3201/eid0202.960213

Ashford DA, 1998, Studies on control of visceral leishmaniasis: impact of dog control on canine and human visceral leishmaniasis in Jacobina, Bahia, Brazil, Am J Trop Med Hyg, 59, 53, 10.4269/ajtmh.1998.59.53

10.1136/vr.141.21.539

10.1016/S0304-4017(98)00169-1

Pinelli E, 1994, Cellular and humoral responses in dogs experimentally and naturally infected with Leishmania infantum, Infect Immun, 62, 229, 10.1128/iai.62.1.229-235.1994

10.1016/S0304-4017(00)00223-5

10.1016/S0165-2427(99)00073-2

10.1016/0165-2427(95)05434-8

10.1002/eji.1830250619

10.1016/S0165-2427(99)00048-3

10.1016/S0165-2427(02)00134-4

10.1111/j.1365-3024.1991.tb00550.x

Vouldoukis I, 1996, Canine visceral leishmaniasis: successful chemotherapy induces macrophage antileishmanial activity via the L‐arginine nitric oxide pathway, Antimicrob Agents Chemother, 40, 253, 10.1128/AAC.40.1.253

10.1016/S0304-4017(00)00312-5

10.1016/S0147-9571(00)00026-6

10.1016/j.ijpara.2004.10.015

10.1016/S0264-410X(03)00032-X

10.1016/j.vetimm.2004.08.010

10.1086/319869

10.1172/JCI116570

10.1128/IAI.73.6.3787-3789.2005

10.1016/j.vaccine.2005.02.009

10.1111/j.1365-3024.1995.tb00914.x

10.1016/S0165-2427(98)00213-X

10.1016/S0165-2427(97)00072-X

10.1016/S0165-2427(01)00270-7

10.1016/S0165-2427(02)00311-2

10.1016/j.vetimm.2004.08.024

10.1016/j.vetimm.2004.08.011

10.1016/S0952-7915(03)00068-2

10.1128/IAI.70.6.2763-2771.2002

10.1007/s00251-003-0545-1

10.1073/pnas.160197797

Lasri S, 1999, Immune responses in vaccinated dogs with autoclaved Leishmania major promastigotes, Vet Res, 30, 441

10.1590/S0074-02761996000600006

Genaro O, 1996, Phase III randomized double blind clinical trial on the efficacy of a vaccine against canine visceral leishmaniasis in urban area of Montes Claros, MG, Brazil, Mem Inst Oswaldo Cruz, 91, 166

Mohebali M, 1998, Vaccine trial against canine visceral leishmaniasis in the Islamic Republic of Iran, East Med Health J, 4, 234, 10.26719/1998.4.2.234

Fallah E, 2000, Preparation and evaluation of Leishmania vaccines in Iran for the control of kala‐azar, Acta Parasitol, 45, 202

10.1016/j.vaccine.2004.03.058

10.1016/0304-4017(88)90016-7

10.1111/j.1365-3024.1989.tb00676.x

10.1016/S0264-410X(00)00339-X

10.1016/S0264-410X(02)00294-3

10.1016/S0264-410X(03)00046-X

10.1016/j.vaccine.2003.11.039

10.1016/j.vaccine.2005.05.011

10.1016/j.vaccine.2004.11.061

10.1016/0769-2625(88)90036-0

Soto M, 1998, Multicomponent chimeric antigen for serodiagnosis of canine visceral leishmaniasis, J Clin Microbiol, 36, 58, 10.1128/JCM.36.1.58-63.1998

10.1016/S0165-2427(02)00315-X

10.1051/vetres:2005033

10.1016/j.vaccine.2005.07.001

Dias SS, 2005, A recombinant cysteine proteinase from Leishmania (Leishmania) chagasi suitable for serodiagnosis of American visceral leishmaniasis, Am J Trop Med Hyg, 72, 126, 10.4269/ajtmh.2005.72.126

10.1016/S0014-4894(03)00097-3

10.1016/j.vetpar.2003.11.013

Pinheiro PHC, Immunization of dogs with a recombinant cysteine proteinase from Leishmania (Leishmania) chagasi (rLdccys1) in an endemic area of visceral leishmaniasis, Teresina/PI.

10.1016/0035-9203(94)90446-4

10.1128/JCM.42.11.5249-5255.2004

10.1645/GE-264R1

10.1016/S0304-4017(01)00486-1

10.1016/j.vetimm.2003.08.005