Rising prevalence of multiple sclerosis worldwide: Insights from the Atlas of MS, third edition Tập 26 Số 14 - Trang 1816-1821 - 2020
Clare Walton, Rachel King, Lindsay Rechtman, Wendy Kaye, Emmanuelle Leray, Ruth Ann Marrie, Neil Robertson, Nicholas La Rocca, Bernard M.J. Uitdehaag, Ingrid van der Mei, Mitchell T. Wallin, Anne Helme, Ceri Angood Napier, Nick Rijke, Peer Baneke
Background: High-quality epidemiologic data worldwide are needed to improve our
understanding of disease risk, support health policy to meet the diverse needs
of people with multiple sclerosis (MS) and support advocacy efforts. Objectives:
The Atlas of MS is an open-source global compendium of data regarding the
epidemiology of MS and the availability of resources for people with MS reported
at co... hiện toàn bộ
International Pediatric Multiple Sclerosis Study Group criteria for pediatric multiple sclerosis and immune-mediated central nervous system demyelinating disorders: revisions to the 2007 definitions Tập 19 Số 10 - Trang 1261-1267 - 2013
Lauren Krupp, Marc Lecuit, Maria Pia Amato, Brenda Banwell, Tanuja Chitnis, Russell C. Dale, Angelo Ghezzi, Rogier Hintzen, Andrew J. Kornberg, Daniela Pohl, Kevin Rostásy, Sílvia Tenembaum, Evangeline Wassmer
Background: There has been tremendous growth in research in pediatric multiple
sclerosis (MS) and immune mediated central nervous system demyelinating
disorders since operational definitions for these conditions were first proposed
in 2007. Further, the International Pediatric Multiple Sclerosis Study Group
(IPMSSG), which proposed the criteria, has expanded substantially in membership
and in its ... hiện toàn bộ
The Multiple Sclerosis Functional Composite measure (MSFC): an integrated approach to MS clinical outcome assessment Tập 5 Số 4 - Trang 244-250 - 1999
Jill S. Fischer, Richard A. Rudick, Gary Cutter, Stephen L. Hauser
Clinical outcome assessment in Multiple Sclerosis (MS) is challenging due to the
diversity and fluctuating nature of MS symptoms. Traditional clinical scales
such as the EDSS are inadequate in their assessment of key clinical dimensions
of MS (e.g., cognitive function), and they have psychometric limitations as
well. Based on analyses of pooled data from natural history studies and from
placebo gr... hiện toàn bộ
New insights into the burden and costs of multiple sclerosis in Europe Tập 23 Số 8 - Trang 1123-1136 - 2017
Gisela Kobelt, Alan J. Thompson, Jenny Berg, Mia Gannedahl, Jennifer Eriksson
Background: The current focus in multiple sclerosis (MS) is on early diagnosis
and drug intervention, with a view to modifying disease progression.
Consequently, healthcare costs have shifted from inpatient care and
rehabilitation to outpatient care. Objectives: This European burden of illness
study provides data that can be combined with other evidence to assess whether
management approaches prov... hiện toàn bộ
ECTRIMS/EAN Guideline on the pharmacological treatment of people with multiple sclerosis Tập 24 Số 2 - Trang 96-120 - 2018
Xavier Montalbán, Ralf Gold, Alan J. Thompson, Susana Otero-Romero Otero-Romero, Maria Pia Amato, Dhia Chandraratna, M. Clanet, Carlo Pozzilli, Tobias Derfuß, Franz Fazekas, Hans-Peter Hartung, Eva Havrdová, Bernhard Hemmer, Ludwig Kappos, Roland Liblau, Catherine Lubetzki, Elena Marcus, David H. Miller, Tomas Olsson, Steve Pilling, Krzysztof Selmaj, Aksel Sıva, Per Soelberg Sørensen, Maria Pia Sormani, Christoph Thalheim, Heinz Wiendl, Frauke Zipp
Background: Multiple sclerosis (MS) is a complex disease with new drugs becoming
available in the past years. There is a need for a reference tool compiling
current data to aid professionals in treatment decisions. Objectives: To develop
an evidence-based clinical practice guideline for the pharmacological treatment
of people with MS. Methods: This guideline has been developed using the Grading
of... hiện toàn bộ
Gait and balance impairment in early multiple sclerosis in the absence of clinical disability Tập 12 Số 5 - Trang 620-628 - 2006
C L Martin, Beverley A. Phillips, Trevor J. Kilpatrick, Helmut Butzkueven, Niall Tubridy, Elizabeth McDonald, Mary P. Galea
This study evaluated the gait and balance performance of two clinically distinct
groups of recently diagnosed and minimally impaired multiple sclerosis (MS)
patients (Expanded Disability Status Scale range 0- 2.5), compared to control
subjects. Ten MS patients with mild pyramidal signs (Pyramidal Functional
Systems 1.0), 10 MS patients with no pyramidal signs (Pyramidal Functional
Systems 0) and 2... hiện toàn bộ
Patient perception of bodily functions in multiple sclerosis: gait and visual function are the most valuable Tập 14 Số 7 - Trang 988-991 - 2008
Christoph Heesen, Jiří Böhm, Christine Reich, Jürgen Kasper, M Goebel, Stefan M. Gold
Multiple sclerosis is a heterogeneous disease with varying clinical picture.
There have been substantial efforts to develop outcome measurements for
therapeutic interventions but very few studies have addressed the value of
bodily functions from the patient perspective. In a randomly selected cohort of
early (<5 years, n = 84) and longer lasting disease courses (>15 years, n = 82)
patients we aske... hiện toàn bộ
Fatigue associated with multiple sclerosis: diagnosis, impact and management Tập 9 Số 3 - Trang 219-227 - 2003
Rohit Bakshi
In patients with multiple sclerosis (MS) fatigue is the most common symptom and
one of the most disabling features. A s many as 40% have described it as the
single most disabling symptom - a higher percentage than weakness, spasticity,
motor problems, or bowel or bladder problems. The etiology and patho physiology
of MS-related fatigue remain unknown. Studies have failed to demonstrate an
associat... hiện toàn bộ
Screening for cognitive impairment in multiple sclerosis using the Symbol Digit Modalities Test Tập 13 Số 1 - Trang 52-57 - 2007
Brett A. Parmenter, Bianca Weinstock‐Guttman, Neeta Garg, Frederick Munschauer, Ralph H. B. Benedict
Cognitive impairment is common in multiple sclerosis (MS), yet difficult to
detect duringroutine neurologic examination. Therefore, briefscreening tests
that identify patients who may benefit from a more thorough assessment or
treatment are needed. We investigated the utility of the Symbol Digit Modalities
Test (SDMT) as a screen for cognitive dysfunction because it can be administered
and scored ... hiện toàn bộ
Radiological differentiation of optic neuritis with myelin oligodendrocyte glycoprotein antibodies, aquaporin-4 antibodies, and multiple sclerosis Tập 22 Số 4 - Trang 470-482 - 2016
Sudarshini Ramanathan, Kristina Prelog, Elizabeth H. Barnes, Esther Tantsis, Stephen W. Reddel, Andrew Henderson, Steve Vucic, Mark Gorman, Leslie Benson, Gülay Alper, Catherine J. Riney, Michael Barnett, John Parratt, Todd A. Hardy, Richard J. Leventer, Vera Merheb, Margherita Nosadini, Victor S.C. Fung, Fabienne Brilot, Russell C. Dale
Background: Recognizing the cause of optic neuritis (ON) affects treatment
decisions and visual outcomes. Objective: We aimed to define radiological
features of first-episode demyelinating ON. Methods: We performed blinded
radiological assessment of 50 patients presenting with first-episode myelin
oligodendrocyte glycoprotein (MOG) antibody-associated ON (MOG-ON; n=19),
aquaporin-4 (AQP4) antibody... hiện toàn bộ