Radiological differentiation of optic neuritis with myelin oligodendrocyte glycoprotein antibodies, aquaporin-4 antibodies, and multiple sclerosis

Multiple Sclerosis Journal - Tập 22 Số 4 - Trang 470-482 - 2016
Sudarshini Ramanathan1, Kristina Prelog2, Elizabeth H. Barnes3, Esther Tantsis4, Stephen W. Reddel5, Andrew Henderson6, Steve Vucic7, Mark Gorman8, Leslie Benson8, Gülay Alper9, Catherine J. Riney10, Michael Barnett11, John Parratt12, Todd A. Hardy13, Richard J. Leventer14, Vera Merheb4, Margherita Nosadini4, Victor S.C. Fung15, Fabienne Brilot4, Russell C. Dale4
1Neuroimmunology group, Institute for Neuroscience and Muscle Research, The Kids Research Institute at the Children’s Hospital at Westmead, Sydney Medical School, University of Sydney, Sydney, Australia/Department of Neurology, Westmead Hospital, and Sydney Medical School, University of Sydney, Sydney, Australia
2Department of Medical Imaging, The Children’s Hospital at Westmead, Sydney, Australia
3NHMRC Clinical Trials Centre, University of Sydney, Sydney, Australia
4Neuroimmunology group, Institute for Neuroscience and Muscle Research, The Kids Research Institute at the Children’s Hospital at Westmead, Sydney Medical School, University of Sydney, Sydney, Australia
5Department of Neurology, Concord Repatriation General Hospital, Sydney, Australia/Brain and Mind Research Institute, University of Sydney, Sydney, Australia
6Department of Neurology, Westmead Hospital, and Sydney Medical School, University of Sydney, Sydney, Australia/Department of Ophthalmology, Westmead Hospital, Sydney, Australia
7Department of Neurology, Westmead Hospital, and Sydney Medical School, University of Sydney, Sydney, Australia/Western Clinical School, University of Sydney, Sydney, Australia
8Boston Children’s Hospital, Boston, United States of America
9Children’s Hospital of Pittsburgh, Department of Pediatrics, University of Pittsburgh, School of Medicine, Pittsburgh, United States of America
10Neurosciences Unit, Lady Cilento Children’s Hospital, Brisbane, Australia; School of Medicine, University of Queensland, Brisbane, Australia
11Brain and Mind Research Institute, University of Sydney, Sydney, Australia/Department of Neurology, Royal Prince Alfred Hospital, Sydney, Australia
12Department of Neurology, Royal North Shore Hospital, Central Clinical School, University of Sydney, Sydney, Australia
13Brain and Mind Research Institute, University of Sydney, Sydney, Australia/Department of Neurology, Concord Repatriation General Hospital, Sydney, Australia
14Department of Neurology, University of Melbourne Department of Paediatrics, Murdoch Children’s Research Institute, The Royal Children’s Hospital, Melbourne, Australia
15Department of Neurology, Westmead Hospital, and Sydney Medical School, University of Sydney, Sydney, Australia

Tóm tắt

Background:

Recognizing the cause of optic neuritis (ON) affects treatment decisions and visual outcomes.

Objective:

We aimed to define radiological features of first-episode demyelinating ON.

Methods:

We performed blinded radiological assessment of 50 patients presenting with first-episode myelin oligodendrocyte glycoprotein (MOG) antibody-associated ON (MOG-ON; n=19), aquaporin-4 (AQP4) antibody-associated ON (AQP4-ON; n=11), multiple sclerosis (MS)-associated ON (MS-ON; n=13), and unclassified ON ( n=7).

Results:

Bilateral involvement was more common in MOG-ON and AQP4-ON than MS-ON (84% vs. 82% vs. 23%), optic nerve head swelling was more common in MOG-ON (53% vs. 9% vs. 0%), chiasmal involvement was more common in AQP4-ON (5% vs. 64% vs. 15%), and bilateral optic tract involvement was more common in AQP4-ON (0% vs. 45% vs. 0%). Retrobulbar involvement was more common in MOG-ON, whereas intracranial involvement was more common in AQP4-ON. MOG-ON and AQP4-ON had longer lesion lengths than MS-ON. The combination of two predictors, the absence of magnetic resonance imaging brain abnormalities and a higher lesion extent score, showed a good ability to discriminate between an autoantibody-associated ON (MOG or AQP4) and MS. AQP4-ON more frequently had severe and sustained visual impairment.

Conclusion:

MOG-ON and AQP4-ON are more commonly bilateral and longitudinally extensive. MOG-ON tends to involve the anterior optic pathway, whereas AQP4-ON the posterior optic pathway.

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10.1084/jem.20050304

10.1002/ana.21916

10.1186/1742-2094-8-184

10.1001/archneurol.2011.2956

10.1177/1352458512470310

10.1212/NXI.0000000000000012

10.1212/WNL.0b013e31826aac4e

10.1001/jamaneurol.2013.5857

10.1212/WNL.0000000000000101

10.1212/NXI.0000000000000040

10.1177/1352458514555785

10.1093/brain/awh260

10.3109/08916934.2013.796938

10.1001/archneur.63.3.390

10.1212/01.wnl.0000314832.24682.c6

10.1111/j.1600-0404.2008.01012.x

10.1097/WNO.0b013e318254c62d

10.1097/WNO.0b013e318283c3ed

10.1177/0883073813520500

10.1136/jnnp-2014-310206

10.1002/ana.22366

10.1212/WNL.33.11.1444

10.1212/WNL.58.1.143

10.1093/brain/aws109

10.1001/archneurol.2011.216

10.1177/1352458511431973

10.1007/s00415-013-7169-7

10.1186/2051-5960-2-35

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Multiple Sclerosis Journal

Tập 22 Số 4

470-482

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