International Pediatric Multiple Sclerosis Study Group criteria for pediatric multiple sclerosis and immune-mediated central nervous system demyelinating disorders: revisions to the 2007 definitions

Multiple Sclerosis Journal - Tập 19 Số 10 - Trang 1261-1267 - 2013
Lauren Krupp1, Marc Lecuit2, Maria Pia Amato3, Brenda Banwell4, Tanuja Chitnis5, Russell C. Dale6, Angelo Ghezzi7, Rogier Hintzen8, Andrew J. Kornberg9, Daniela Pohl10, Kevin Rostásy11, Sílvia Tenembaum12, Evangeline Wassmer13
1Lourie Center for Pediatric MS. Stony Brook University Medical Center, USA
2Neuropediatrie, Hospitaux Universitaire Paris Sud, France
3Neurology, University of Florence, Italy
4Neurology, Children’s Hospital of Philadelphia, USA
5Neurology, Massachusetts General Hospital for Children, USA
6Paediatrics and Child Health, University of Sydney, Australia
7Centro Studi Sclerosi Multipl, Ospedale di Gallarate, Italy
8Neurology, Erasmus MC, Netherlands
9Neurology Parkville, Royal Children’s Hospital, Victoria, Australia
10Neurology, Children’s Hospital of Eastern Ontario, Canada
11Pediatric Neurology, Medical University Innsbruck, Austria
12Neurology, Dr Juan P Garrahan National Pediatric Hospital, Argentina
13Neurology, Birmingham Children’s Hospital, UK

Tóm tắt

Background: There has been tremendous growth in research in pediatric multiple sclerosis (MS) and immune mediated central nervous system demyelinating disorders since operational definitions for these conditions were first proposed in 2007. Further, the International Pediatric Multiple Sclerosis Study Group (IPMSSG), which proposed the criteria, has expanded substantially in membership and in its international scope. Objective: The purpose of this review is to revise the 2007 definitions in order to incorporate advances in delineating the clinical and neuroradiologic features of these disorders. Methods: Through a consensus process, in which input was sought from the 150 members of the Study Group, criteria were drafted, revised and finalized. Final approval was sought through a web survey. Results: Revised criteria are proposed for pediatric acute disseminated encephalomyelitis, pediatric clinically isolated syndrome, pediatric neuromyelitis optica and pediatric MS. These criteria were approved by 93% or more of the 56 Study Group members who responded to the final survey. Conclusions: These definitions are proposed for clinical and research purposes. Their utility will depend on the outcomes of their application in prospective research.

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Multiple Sclerosis Journal

Tập 19 Số 10

1261-1267

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