The Multiple Sclerosis Functional Composite measure (MSFC): an integrated approach to MS clinical outcome assessment

Multiple Sclerosis Journal - Tập 5 Số 4 - Trang 244-250 - 1999
Jill S. Fischer1, Richard A. Rudick1, Gary Cutter2, Stephen L. Hauser3
1Mellen Center (U-10), Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio OH 44195-5244 USA
2Center for Research Methodology and Biometrics, AMC Cancer Research Center, 1600 Pierce Street, Lakewood, Colorado CO 80214 USA
3Research Programs Department, National MS Society, 733 Third Avenue, New York, NY 10017 USA

Tóm tắt

Clinical outcome assessment in Multiple Sclerosis (MS) is challenging due to the diversity and fluctuating nature of MS symptoms. Traditional clinical scales such as the EDSS are inadequate in their assessment of key clinical dimensions of MS (e.g., cognitive function), and they have psychometric limitations as well. Based on analyses of pooled data from natural history studies and from placebo groups in clinical trials, the National MS Society's Clinical Outcomes Assessment Task Force recently proposed a new multidimensional clinical outcome measure, the MS Functional Composite (MSFC). The MSFC comprises quantitative functional measures of three key clinical dimensions of MS: leg function/ambulation, arm/hand function, and cognitive function. Scores on component measures are converted to standard scores (z-scores), which are averaged to form a single MSFC score. Preliminary analyses confirm that: (1) the three clinical dimensions of the MSFC are relatively independent; (2) the MSFC is sensitive to clinical changes over 1- and 2-year intervals; and (3) the MSFC has acceptable criterion validity (i.e., predicts both concurrent and subsequent EDSS change). The advantages and potential limitations of incorporating quantitative functional outcome measures such as the MSFC into collaborative databases are discussed.

Từ khóa


Tài liệu tham khảo

10.1212/WNL.33.11.1444

10.1177/135245859500100107

10.1212/WNL.34.10.1368

10.1016/S0140-6736(86)91554-0

10.1177/135245859700300104

Potvin AR, 1985, Quantitative examination of neurologic function. Vol II. Methodology for test and patient assessments and design of a computer-automated system

10.1002/ana.410400321

10.1177/135245859600200305

10.1007/978-1-4471-1271-6_4

Goldsmith CH, 1993, J Rheumatol, 20, 575

10.1002/ana.410420318

10.1212/WNL.39.8.1018

10.1002/ana.410270603

10.1002/ana.410370108

10.1002/ana.410390304

10.1093/brain/122.5.871

Fischer JS, 1999, Administration and scoring manual for the MS Functional Composite measure (MSFC)

10.1212/WNL.49.5.1419

Goodkin D, 1988, Arch Phys Med Rehabil, 69, 850

10.2466/pms.1977.44.2.367

10.1212/WNL.39.2.161

Fischer JS, Neurology, 52, A50

10.1177/135245859500100306

Syndulko K, 1993, J Neuro Rehab, 7, 153

Brooks BR, 1994, Motor neuron disease, 131

Thông tin
Thông tin xuất bản

Multiple Sclerosis Journal

Tập 5 Số 4

244-250

Thông tin tác giả