Multiple Sclerosis Journal

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Production of brain-derived neurotrophic factor by mononuclear cells of patients with multiple sclerosis treated with glatiramer acetate, interferon-β 1a, and high doses of immunoglobulins
Multiple Sclerosis Journal - Tập 13 Số 3 - Trang 313-331 - 2007
Paola Sarchielli, Mauro Zaffaroni, A Floridi, Laura A. Greco, Antonio Candeliere-Merlicco, Alessia Mattioni, Serena Tenaglia, Massimiliano Di Filippo, Paolo Calabresi
Sixty, relapsing remitting (RR) multiple sclerosis (MS) patients, who underwent treatment with glatiramer acetate (GA), interferon (IFN)-β 1a, and immunoglobulins (Igs) (20 per treatment group), were assessed for levels of brain-derived neurotrophic factor (BDNF) in the supernatants of unstimulated and stimulated peripheral blood mononuclear cells (PBMCs) in the first year of treatment. Ph...... hiện toàn bộ
Preferential increase of B-cell activating factor in the cerebrospinal fluid of neuromyelitis optica in a white population
Multiple Sclerosis Journal - Tập 16 Số 12 - Trang 1453-1457 - 2010
Adi Vaknin‐Dembinsky, Livnat Brill, Naama Orpaz, Oded Abramsky, Dimitrios Karussis
Background: Anti-aquaporin-4 antibodies are believed to have a central pathogenetic role in neuromyelitis optica (NMO). B-cell activating factor (BAFF) is one of the crucial factors that determines the fate and survival of B cells and may play a role in induction of antibody-mediated autoimmunity. Objectives: To evaluate the blood and cerebrospinal fluid (CSF) levels of ...... hiện toàn bộ
Serial combination therapy: is immune modulation in multiple sclerosis enhanced by initial immune suppression?
Multiple Sclerosis Journal - Tập 15 Số 8 - Trang 959-964 - 2009
Amit Bar‐Or, Joël Oger, Emma Gibbs, Masaaki Niino, T Aziz, Christel Renoux, Sudabeh Alatab, Fu‐Dong Shi, Denise I. Campagnolo, Farzaneh Jalili, Susan Rhodes, T Yamashita, Bingbing Fan, Marc Freedman, Hillel Panitch, Douglas L. Arnold, Timothy Vollmer
Background Although the concept that an initial course of immune-suppression facilitates subsequent immune-modulation (such as Th1 to Th2 deviation) is attractive for several autoimmune diseases, such a mechanism for serial-combination therapy has never been formally demonstrated. Recently, brief mitoxantrone induction-chemotherapy followed by immune-modulation with glat...... hiện toàn bộ
Distributed changes in default-mode resting-state connectivity in multiple sclerosis
Multiple Sclerosis Journal - Tập 17 Số 4 - Trang 411-422 - 2011
Simona Bonavita, Antonio Gallo, Rosaria Sacco, Marida Della Corte, Alvino Bisecco, Renato Docimo, Luigi Lavorgna, Daniele Corbo, Alfonso Di Costanzo, Fabio Tortora, Mario Cirillo, Fabrizio Esposito, Gioacchino Tedeschi
Background: The default-mode network (DMN) has been increasingly recognized as relevant to cognitive status. Objectives: To explore DMN changes in patients with relapsing–remitting (RR) multiple sclerosis (MS) and to relate these to the cognitive status. Methods: Eighteen cognitively impaired (CI) and eighteen cognitively preserved (CP) RRMS patients an...... hiện toàn bộ
The Multiple Sclerosis Functional Composite measure (MSFC): an integrated approach to MS clinical outcome assessment
Multiple Sclerosis Journal - Tập 5 Số 4 - Trang 244-250 - 1999
Jill S. Fischer, Richard A. Rudick, Gary Cutter, Stephen L. Hauser
Clinical outcome assessment in Multiple Sclerosis (MS) is challenging due to the diversity and fluctuating nature of MS symptoms. Traditional clinical scales such as the EDSS are inadequate in their assessment of key clinical dimensions of MS (e.g., cognitive function), and they have psychometric limitations as well. Based on analyses of pooled data from natural history studies and from p...... hiện toàn bộ
Assessing brain connectivity at rest is clinically relevant in early multiple sclerosis
Multiple Sclerosis Journal - Tập 18 Số 9 - Trang 1251-1258 - 2012
Anthony Faivre, A. Rico, Wafaa Zaaraoui, Lydie Crespy, Françoise Reuter, D. Wybrecht, Elisabeth Soulier, Irina Malikova, Sylviane Confort‐Gouny, Patrick J. Cozzone, Jean Pelletier, Jean‐Philippe Ranjeva, Bertrand Audoin
Objective: The present study aims to determine the clinical counterpart of brain resting-state networks reorganization recently evidenced in early multiple sclerosis. Methods: Thirteen patients with early relapsing–remitting multiple sclerosis and 14 matched healthy controls were included in a...... hiện toàn bộ
Preventing brain atrophy should be the gold standard of effective therapy in multiple sclerosis (after the first year of treatment): Commentary
Multiple Sclerosis Journal - Tập 19 Số 8 - Trang 1007-1008 - 2013
Douglas L. Arnold, Nicola De Stefano
Anti-Epstein–Barr virus antibodies as serological markers of multiple sclerosis: a prospective study among United States military personnel
Multiple Sclerosis Journal - Tập 17 Số 10 - Trang 1185-1193 - 2011
KL Munger, LI Levin, ÉJ O’Reilly, K.I. Falk, Alberto Ascherio
Background: Elevated Epstein–Barr virus (EBV) antibody titers are risk factors for multiple sclerosis (MS), but the strength and consistency of this association are not well characterized. Objectives: The objectives of this study were to determine whether this association is confounded by vitamin D or modified by gender or race, and the usefulness of EBV nuclear antigen ...... hiện toàn bộ
On-road assessment of fitness-to-drive in persons with MS with cognitive impairment: A prospective study
Multiple Sclerosis Journal - Tập 24 Số 11 - Trang 1499-1506 - 2018
Sarah A. Morrow, Sherrilene Classen, Miriam Monahan, Tim Danter, Robert Taylor, Sarah Krasniuk, Heather Rosehart, Wenqing He
Background: Cognitive impairment is common in multiple sclerosis (MS). In other populations, cognitive impairment is known to affect fitness-to-drive. Few studies have focused on fitness-to-drive in MS and no studies have solely focused on the influence of cognitive impairment. Objective: To a...... hiện toàn bộ
Predictors of driving in individuals with relapsing–remitting multiple sclerosis
Multiple Sclerosis Journal - Tập 19 Số 3 - Trang 344-350 - 2013
Abiodun Akinwuntan, Hannes Devos, Lara M. Stepleman, Rhonda S. Casillas, Rebecca Rahn, Suzanne Smith, Mitzi Williams
Background: We previously reported that performance on the Stroke Driver Screening Assessment (SDSA), a battery of four cognitive tests that takes less than 30 min to administer, predicted the driving performance of participants with multiple sclerosis (MS) on a road test with 86% accuracy, 80% sensitivity, and 88% specificity. ... hiện toàn bộ
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