Multiple Sclerosis Journal

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Serial combination therapy: is immune modulation in multiple sclerosis enhanced by initial immune suppression?
Multiple Sclerosis Journal - Tập 15 Số 8 - Trang 959-964 - 2009
Amit Bar‐Or, Joël Oger, Emma Gibbs, Masaaki Niino, T Aziz, Christel Renoux, Sudabeh Alatab, Fu‐Dong Shi, Denise I. Campagnolo, Farzaneh Jalili, Susan Rhodes, T Yamashita, Bingbing Fan, Marc Freedman, Hillel Panitch, Douglas L. Arnold, Timothy Vollmer
Background Although the concept that an initial course of immune-suppression facilitates subsequent immune-modulation (such as Th1 to Th2 deviation) is attractive for several autoimmune diseases, such a mechanism for serial-combination therapy has never been formally demonstrated. Recently, brief mitoxantrone induction-chemotherapy followed by immune-modulation with glat...... hiện toàn bộ
Responder definition of the Multiple Sclerosis Impact Scale physical impact subscale for patients with physical worsening
Multiple Sclerosis Journal - Tập 20 Số 13 - Trang 1753-1760 - 2014
Glenn Phillips, Kathleen W. Wyrwich, Shien Guo, Rossella Medori, Arman Altincatal, Linda D. Wagner, Jacob Elkins
Background: The 29-item Multiple Sclerosis Impact Scale (MSIS-29) was developed to examine the impact of multiple sclerosis (MS) on physical and psychological functioning from a patient’s perspective. Objective: To determine the responder definition (RD) of the MSIS-29 physical impact subscale...... hiện toàn bộ
Chitinase 3-like proteins as diagnostic and prognostic biomarkers of multiple sclerosis
Multiple Sclerosis Journal - Tập 21 Số 10 - Trang 1251-1261 - 2015
Geoffrey Hinsinger, Nicoletta Galeotti, Nicolas Nabholz, Serge Urbach, Valérie Rigau, Christophe Dematteï, Sylvain Lehmann, William Camu, Pierre Labauge, Giovanni Castelnovo, Pierre Labauge, Marc G. Denis, Marion Salou, Olivier Casez, Joël Bockaert, Philippe Marin, Éric Thouvenot
Background: Despite sensitivity of MRI to diagnose multiple sclerosis (MS), prognostic biomarkers are still needed for optimized treatment. Objective: The objective of this paper is to identify cerebrospinal fluid (CSF) diagnostic biomarkers of MS using quantitative proteomics and to analyze t...... hiện toàn bộ
Reducing survey burden: feasibility and validity of PROMIS measures in multiple sclerosis
Multiple Sclerosis Journal - Tập 20 Số 8 - Trang 1102-1111 - 2014
Angela Senders, Douglas Hanes, Dennis Bourdette, Ruth H. Whitham, Lynne Shinto
Background: Patient-reported outcomes are important for clinical research and care, yet administering and scoring the questionnaires requires considerable effort and time. The Patient Reported Outcomes Measurement Information System (PROMIS) could considerably reduce administrative obstacles and lessen survey burden for participants. <...... hiện toàn bộ
International consensus on quality standards for brain health-focused care in multiple sclerosis
Multiple Sclerosis Journal - Tập 25 Số 13 - Trang 1809-1818 - 2019
Jeremy Hobart, Amy Bowen, George Pepper, H. S. Crofts, Lucy Eberhard, Thomas Berger, Alexey Boyко, Cavit Boz, Helmut Butzkueven, Elisabeth Gulowsen Celius, Jelena Drulović, José Flores, Dana Horáková, Christine Lebrun‐Frénay, Ruth Ann Marrie, James Overell, Fredrik Piehl, Peter Vestergaard Rasmussen, María José Sá, Carmen Adella Sîrbu, Eli Skromne, Øivind Torkildsen, Vincent Van Pesch, Timothy Vollmer, Magd Zakaria, Heinz Wiendl, Gavin Giovannoni
Background: Time matters in multiple sclerosis (MS). Irreversible neural damage and cell loss occur from disease onset. The MS community has endorsed a management strategy of prompt diagnosis, timely intervention and regular proactive monitoring of treatment effectiveness and disease activity to improve outcomes in people with MS. ... hiện toàn bộ
ECTRIMS/EAN Guideline on the pharmacological treatment of people with multiple sclerosis
Multiple Sclerosis Journal - Tập 24 Số 2 - Trang 96-120 - 2018
Xavier Montalbán, Ralf Gold, Alan J. Thompson, Susana Otero-Romero Otero-Romero, Maria Pia Amato, Dhia Chandraratna, M. Clanet, Carlo Pozzilli, Tobias Derfuß, Franz Fazekas, Hans-Peter Hartung, Eva Havrdová, Bernhard Hemmer, Ludwig Kappos, Roland Liblau, Catherine Lubetzki, Elena Marcus, David H. Miller, Tomas Olsson, Steve Pilling, Krzysztof Selmaj, Aksel Sıva, Per Soelberg Sørensen, Maria Pia Sormani, Christoph Thalheim, Heinz Wiendl, Frauke Zipp
Background: Multiple sclerosis (MS) is a complex disease with new drugs becoming available in the past years. There is a need for a reference tool compiling current data to aid professionals in treatment decisions. Objectives: To develop an evidence-based clinical practice guideline for the ph...... hiện toàn bộ
Is Devic's neuromyelitis optica a separate disease? A comparative study with multiple sclerosis
Multiple Sclerosis Journal - Tập 9 Số 5 - Trang 521-525 - 2003
H. Devilliers, Christine Lebrun‐Frénay, Tanya Stojkovic, D. Ferriby, M. Chatel, Patrick Vermersch
Devic's neuromyelitis optica (NMO) associates optic neuritis and myelopathy without other neurological signs. Many patients with NMO may be diagnosed as having multiple sclerosis (MS). However, there have been no previous studies comparing these two patho logies and it is still unclear if NMO is a separate entity or a subtype of MS. In the present study, we compared a series of NMO patien...... hiện toàn bộ
Patient perception of bodily functions in multiple sclerosis: gait and visual function are the most valuable
Multiple Sclerosis Journal - Tập 14 Số 7 - Trang 988-991 - 2008
Christoph Heesen, Jiří Böhm, Christine Reich, Jürgen Kasper, M Goebel, Stefan M. Gold
Multiple sclerosis is a heterogeneous disease with varying clinical picture. There have been substantial efforts to develop outcome measurements for therapeutic interventions but very few studies have addressed the value of bodily functions from the patient perspective. In a randomly selected cohort of early (<5 years, n = 84) and longer lasting disease courses (>15 years, n = 82) p...... hiện toàn bộ
A profile of multiple sclerosis: The New York State Multiple Sclerosis Consortium
Multiple Sclerosis Journal - Tập 5 Số 5 - Trang 369-376 - 1999
Lawrence Jacobs, Karl Wende, Carol M. Brownscheidle, Brian Apatoff, Patricia K. Coyle, Andrew Goodman, Malcolm Gottesman, Carl V. Granger, Steven J. Greenberg, Joseph Herbert, Lauren Krupp, Neil Lava, Cornelia Mihai, Aaron Miller, Allan Perel, Charles R. Smith, David H. Snyder
We have obtained a current profile of multiple sclerosis (MS) in New York State through a centralized patient registry and standardized data collection instrument associated with the New York State Multiple Sclerosis Consortium of 12 MS centers located throughout the state. Data from the first 3019 patients with clinically definite MS revealed a clear relationship between MS disease type,...... hiện toàn bộ
Screening for cognitive impairment in multiple sclerosis using the Symbol Digit Modalities Test
Multiple Sclerosis Journal - Tập 13 Số 1 - Trang 52-57 - 2007
Brett A. Parmenter, Bianca Weinstock‐Guttman, Neeta Garg, Frederick Munschauer, Ralph H. B. Benedict
Cognitive impairment is common in multiple sclerosis (MS), yet difficult to detect duringroutine neurologic examination. Therefore, briefscreening tests that identify patients who may benefit from a more thorough assessment or treatment are needed. We investigated the utility of the Symbol Digit Modalities Test (SDMT) as a screen for cognitive dysfunction because it can be administered an...... hiện toàn bộ
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