AbstractIn the field of cardio-oncology, it is well recognised that despite the benefits of chemotherapy in treating and possibly curing cancer, it can cause catastrophic damage to bystander tissues resulting in a range of potentially of life-threatening cardiovascular toxicities, and leading to a number of damaging side effects including heart failure and myocardi...... hiện toàn bộ
Richard W. Troughton, Jay Ritzema, Neal Eigler, Iain Melton, Henry Krum, Philip B. Adamson, Saibal Kar, Prediman K. Shah, James S. Whiting, J. Thomas Heywood, Spencer Rosero, Jagmeet P. Singh, Leslie A. Saxon, Ray V. Matthews, Ian Crozier, William T. Abraham
The potency of specific transcription factors as cell fate determinants was first demonstrated by the discovery of MyoD, a master gene for skeletal muscle transdifferentiation. More recently, the induction of pluripotency in somatic cells using a combination of stem cell-specific transcription factors has been reported. That elegant study altered the approach to regenerative medicine and inspired ...... hiện toàn bộ