Journal of Cardiovascular Translational Research
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Circulating exosome-derived miR-122-5p is a novel biomarker for prediction of postoperative atrial fibrillation
Journal of Cardiovascular Translational Research - Tập 15 - Trang 1393-1405 - 2022
Postoperative atrial fibrillation (POAF) is a frequent complication associated with increased periprocedural mortality and morbidity after cardiac surgery. Our study aimed to identify the difference in exosomal miRNA and further explore its role in the diagnosis of POAF. First, the differentially expressed miRNAs (DEMs) were obtained by high-throughput RNA sequencing. Second, the DEMs target genes...... hiện toàn bộ
MicroRNA Expression and Function in Cardiac Ischemic Injury
Journal of Cardiovascular Translational Research - Tập 3 - Trang 241-245 - 2010
Ischemic heart disease (IHD) or myocardial ischemia is one of the leading causes of mortality all over the world. There is a definite need for new approaches to improve therapies and diagnostics. The pathological process leading to IHD is associated with an altered expression of genes that are important for cardiac functions. MicroRNAs (miRNAs) have emerged as one of the central players regulating...... hiện toàn bộ
Wild-Type Transthyretin Cardiac Amyloidosis Is Associated with Increased Antecedent Physical Activity
Journal of Cardiovascular Translational Research - Tập 15 - Trang 689-691 - 2022
Modulation of Insulin Sensitivity by Exercise Training: Implications for Cardiovascular Prevention
Journal of Cardiovascular Translational Research - Tập 14 - Trang 256-270 - 2020
The beneficial effects of physical activity on the cardiovascular system nowadays have achieved the relevance of clinical evidence. In fact, several studies have documented the benefits of exercise training in the prevention of the cardiovascular risk. Abnormalities of insulin signaling transduction account for the impairment of insulin sensitivity and development of insulin resistance, which, in ...... hiện toàn bộ
Elastin in Large Artery Stiffness and Hypertension
Journal of Cardiovascular Translational Research - Tập 5 - Trang 264-273 - 2012
Large artery stiffness, as measured by pulse wave velocity, is correlated with high blood pressure and may be a causative factor in essential hypertension. The extracellular matrix components, specifically the mix of elastin and collagen in the vessel wall, determine the passive mechanical properties of the large arteries. Elastin is organized into elastic fibers in the wall during arterial develo...... hiện toàn bộ
Improving Nocturnal Hypoxemic Burden with Transvenous Phrenic Nerve Stimulation for the Treatment of Central Sleep Apnea
Journal of Cardiovascular Translational Research - Tập 14 - Trang 377-385 - 2020
Nocturnal hypoxemic burden is established as a robust prognostic metric of sleep-disordered breathing (SDB) to predict mortality and treating hypoxemic burden may improve prognosis. The aim of this study was to evaluate improvements in nocturnal hypoxemic burden using transvenous phrenic nerve stimulation (TPNS) to treat patients with central sleep apnea (CSA). The remedē System Pivotal Trial popu...... hiện toàn bộ
Impact of Left Atrial Sphericity Index on the Outcome of Catheter Ablation for Atrial Fibrillation
Journal of Cardiovascular Translational Research - Tập 14 - Trang 912-920 - 2021
Left atrial sphericity index (LASI) is one significant geometric remodeling parameter to evaluate the prognosis of atrial fibrillation (AF). We aimed to determine whether transthoracic echocardiography (TTE)–derived LASI may help predict the outcomes following AF radiofrequency catheter ablation (RFCA). This prospective study enrolled 190 consecutive AF patients who underwent TTE 24 h before RFCA....... hiện toàn bộ
Meet Me Halfway: When Genomics Meets Structural Bioinformatics
Journal of Cardiovascular Translational Research - Tập 4 - Trang 281-303 - 2011
The DNA sequencing technology developed by Frederick Sanger in the 1970s established genomics as the basis of comparative genetics. The recent invention of next-generation sequencing (NGS) platform has added a new dimension to genome research by generating ultra-fast and high-throughput sequencing data in an unprecedented manner. The advent of NGS technology also provides the opportunity to study ...... hiện toàn bộ
Inhibition of lncRNA DANCR Prevents Heart Failure by Ameliorating Cardiac Hypertrophy and Fibrosis Via Regulation of the miR-758-3p/PRG4/Smad Axis
Journal of Cardiovascular Translational Research - Tập 16 - Trang 1357-1372 - 2023
The current work was developed to explore the functions and possible mechanism of PRG4 in cardiac hypertrophy and heart failure. Ang II-stimulated H9c2 cells and AC16 cells were used as in vitro cell models. The binding relation between genes in cells was explored using luciferase reporter assays and RNA immunoprecipitation assay. The cardiac functions of rats received transverse-ascending aortic ...... hiện toàn bộ
The Role of Cardiac PET in Translating Basic Science into the Clinical Arena
Journal of Cardiovascular Translational Research - Tập 4 - Trang 425-436 - 2011
Non-invasive imaging has become fundamental in translating findings from basic science research into clinical applications. In this aspect, positron-emission tomography (PET) offers important advantages over other common imaging modalities like single-photon emission computed tomography, computed tomography, and magnetic resonance imaging (MRI), since PET provides superior detection sensitivity in...... hiện toàn bộ
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