Journal of Cardiovascular Translational Research
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iPS Cell Modeling of Cardiometabolic Diseases
Journal of Cardiovascular Translational Research - Tập 6 - Trang 46-53 - 2012
Cardiometabolic diseases encompass simple monogenic enzyme deficiencies with
well-established pathogenesis and clinical outcomes to complex polygenic
diseases such as the cardiometabolic syndrome. The limited availability of
relevant human cell types such as cardiomyocytes has hampered our ability to
adequately model and study pathways or drugs relevant to these diseases in the
heart. The recent d...
Efficacy and Dosage Pattern of Sacubitril/Valsartan in Chinese Heart Failure with Reduced Ejection Fraction Patients
Journal of Cardiovascular Translational Research - Tập 15 - Trang 1192-1202 - 2022
This study aims to investigate the dosage pattern, efficacy, and safety of
sacubitril/valsartan (Sac/Val) in Chinese heart failure with reduced ejection
fraction (HFrEF) patients regarding real-world settings. Patients from 27
centers with a confirmed diagnosis of HFrEF and initiated Sac/Val treatment were
enrolled. The primary objective was to evaluate the dosage pattern and change of
heart failu...
Empagliflozin for Patients with Heart Failure and Type 2 Diabetes Mellitus: Clinical Evidence in Comparison with Other Sodium-Glucose Co-transporter-2 Inhibitors and Potential Mechanism
Journal of Cardiovascular Translational Research - Tập 16 - Trang 327-340 - 2022
Heart failure remains a leading cause of morbidity and mortality globally and
has been recognized as a common complication of diabetes, especially type 2
diabetes mellitus. Heart failure occurs in diabetic patients even in the absence
of hypertension, coronary heart disease, or valvular heart disease, and is,
therefore, a major cardiovascular complication in this vulnerable population.
Given the c...
Clinical Practice and Research in Cardio-Oncology: Finding the “Rosetta Stone” for Establishing Program Excellence in Cardio-oncology
Journal of Cardiovascular Translational Research - Tập 13 - Trang 495-505 - 2020
The burgeoning field of cardio-oncology (C-O) is now necessary for the delivery
of excellent care for patients with cancer. Many factors have contributed to
this increasing population of cancer survivors or those being treated with novel
and targeted cancer therapies. There is a tremendous need to provide outstanding
cardiovascular (CV) care for these patients; however, current medical literature
...
Diagnostic and Prognostic Value of Coronary Computed Tomography Angiography in Patients with Severe Calcification
Journal of Cardiovascular Translational Research - Tập 14 - Trang 131-139 - 2020
Our aim was to analyze its diagnostic and prognostic value in patients with high
coronary calcium score (CCS). A total of 113 patients with CCS > 400 were
included. Significant coronary artery disease (CAD) was defined as stenosis ≥
50%. Invasive coronary angiography and major cardiovascular events were
recorded. The CCS and heart rate during the acquisition were significantly lower
in the diagnos...
Myocarditis in the Athlete: Arrhythmogenic Substrates, Clinical Manifestations, Management, and Eligibility Decisions
Journal of Cardiovascular Translational Research - Tập 13 Số 3 - Trang 284-295 - 2020
Myocarditis is as an important cause of sudden cardiac death (SCD) among
athletes. The incidence of SCD ascribed to myocarditis did not change after the
introduction of pre-participation screening in Italy, due to the transient
nature of the disease and problems in the differential diagnosis with the
athlete’s heart. The arrhythmic burden and the underlying mechanisms differ
between the acute and ...
Predictive Models for Pulmonary Artery Size in Fontan Patients
Journal of Cardiovascular Translational Research - Tập 14 - Trang 782-789 - 2020
We developed models of pulmonary artery (PA) size in Fontan patients as a
function of age and body surface area (BSA) using linear regression and
breakpoint analyses based on data from 43 Fontan patients divided into two
groups: the extracardiac conduit (ECC) group (n = 24) and the non-ECC group
(n = 19). Model predictions were compared against those of a non-Fontan control
group (n = 18) and publ...
Metabolic Reprogramming in Cardiovascular Diseases
Journal of Cardiovascular Translational Research - - Trang 1-3 - 2024
Non-invasive Thoracic Impedance Changes in COVID-19 Pulmonary Infection
Journal of Cardiovascular Translational Research - - 2021
Intermittent Occlusion of the Superior Vena Cava Reduces Cardiac Filling Pressures in Preclinical Models of Heart Failure
Journal of Cardiovascular Translational Research - - 2020
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