Clinical Practice and Research in Cardio-Oncology: Finding the “Rosetta Stone” for Establishing Program Excellence in Cardio-oncologyJournal of Cardiovascular Translational Research - Tập 13 - Trang 495-505 - 2020
Srinath Adusumalli, Jose Alvarez-Cardona, Sameed M. Khatana, Joshua D. Mitchell, Anne H. Blaes, Stephen J. Casselli, Rupal O’Quinn, Daniel J. Lenihan
The burgeoning field of cardio-oncology (C-O) is now necessary for the delivery of excellent care for patients with cancer. Many factors have contributed to this increasing population of cancer survivors or those being treated with novel and targeted cancer therapies. There is a tremendous need to provide outstanding cardiovascular (CV) care for these patients; however, current medical literature ...... hiện toàn bộ
Predictive Models for Pulmonary Artery Size in Fontan PatientsJournal of Cardiovascular Translational Research - Tập 14 - Trang 782-789 - 2020
Akash Gupta, Chris Gillett, Patrick Gerard, Michael M. H. Cheung, Jonathan P. Mynard, Ethan Kung
We developed models of pulmonary artery (PA) size in Fontan patients as a function of age and body surface area (BSA) using linear regression and breakpoint analyses based on data from 43 Fontan patients divided into two groups: the extracardiac conduit (ECC) group (n = 24) and the non-ECC group (n = 19). Model predictions were compared against those of a non-Fontan control group (n = 18) and publ...... hiện toàn bộ
A Review of the Role of Electronic Health Record in Genomic ResearchJournal of Cardiovascular Translational Research - Tập 7 - Trang 692-700 - 2014
Parasuram Krishnamoorthy, Deepansh Gupta, Saurav Chatterjee, Jessica Huston, John J. Ryan
Electronic health record (EHR)-driven genomic research is a recent strategy used to answer research questions using EHR data linked to DNA samples. In models using EHR, after the subject’s DNA is collected, a linkage between the DNA sample and the EHR data is maintained. This makes the EHR the paramount source of phenotypic information. The National Human Genome Research Institute sponsored Electr...... hiện toàn bộ
CYP-Mediated Pharmacologic Interference with Optimal Platelet InhibitionJournal of Cardiovascular Translational Research - Tập 6 - Trang 404-410 - 2013
Thomas Cuisset, Jacques Quilici
Variability of response to clopidogrel and prasugrel is a multifactorial process, with clinical consequences, and drug-drug interactions have been proposed as potential factors. Biological modulation of clopidogrel response has been demonstrated for atorvastatin and omeprazole. However, investigations assessing clinical relevance of these findings have been heterogeneous, and real clinical impact ...... hiện toàn bộ
Heart Failure with Recovered Ejection Fraction in Patients with Vinculin Loss-of-function VariantsJournal of Cardiovascular Translational Research - - Trang 1-7 - 2023
Laura Zahavich, Rajadurai Akilen, Kristen George, Seema Mital
Predictors of myocardial recovery in heart failure (HF) are poorly understood. We explored if vinculin (VCL) variants are associated with myocardial recovery in dilated cardiomyopathy (DCM). Six infants with DCM with a VCL loss-of-function (LOF) variant were identified. Median age at diagnosis was 2 months, median LV ejection fraction was 24%, and median LV end-diastolic diameter z-score was 10.8....... hiện toàn bộ
Translating Clinical Research to the Bedside: The Minnesota ModelJournal of Cardiovascular Translational Research - Tập 1 - Trang 292-294 - 2008
Jennifer L. Hall, Leslie W. Miller, Soon J. Park
Minnesota is home to two of the pioneering institutions that ushered in the golden era of modern cardiac surgery. Clinicians and researchers at the Mayo Clinic and the University of Minnesota built on this momentum and began translating clinical research directly to the bedside. This legacy continues today. Minnesota has a rich history and track record of translating clinical research to the bedsi...... hiện toàn bộ
Methodological Review of Ventricular Anatomy—the Basis for Understanding Congenital Cardiac MalformationsJournal of Cardiovascular Translational Research - Tập 6 - Trang 145-154 - 2012
Diane E. Spicer, Robert H. Anderson
The ventricular mass extends from the atrioventricular to the ventriculo–arterial junctions. The junctions are obvious anatomic entities and provide discrete boundaries for the ventricles, which can then be subdivided into inlet, apical, and outlet components. The apical trabecular components are most constantly present when hearts are congenitally malformed. Abnormal ventricles, such as found in ...... hiện toàn bộ