AbstractMany complex spike cells in the hippocampus of the freely moving rat have as their primary correlate the animal's location in an environment (place cells). In contrast, the hippocampal electroer cephalograph theta pattern of rhythmical waves (7–12 Hz) is better correlated with a class of movements that change the rat's location in an environment. During mov...... hiện toàn bộ
Eleanor A. Maguire, Katherine Woollett, Hugo J. Spiers
AbstractLicensed London taxi drivers show that humans have a remarkable capacity to acquire and use knowledge of a large complex city to navigate within it. Gray matter volume differences in the hippocampus relative to controls have been reported to accompany this expertise. While these gray matter differences could result from using and updating spatial representa...... hiện toàn bộ
AbstractThe hippocampus is one of several limbic brain structures implicated in the pathophysiology and treatment of mood disorders. Preclinical and clinical studies demonstrate that stress and depression lead to reductions of the total volume of this structure and atrophy and loss of neurons in the adult hippocampus. One of the cellular mechanisms that could accou...... hiện toàn bộ
David M. Diamond, Michael Bennett, Monika Fleshner, Gregory M. Rose
AbstractStudies have shown that peripheral levels of corticosterone correlate with the magnitudes of two well‐described physiological models of memory, long‐term potentiation (LTP) and primed burst (PB) potentiation. In the present experiments, the authors investigated the effects of experimenter‐controlled manipulations of the levels of corticosterone on the magni...... hiện toàn bộ
AbstractWe review the ideas and data behind the hypothesis that hippocampal pyramidal cells encode information by their phase of firing relative to the theta rhythm of the EEG. Particular focus is given to the further hypothesis that variations in firing rate can encode information independently from that encoded by firing phase. We discuss possible explanation of ...... hiện toàn bộ
Andrew P. Yonelinas, Mariam Aly, Wei‐Chun Wang, Joshua D. Koen
AbstractIt is well accepted that recognition memory reflects the contribution of two separable memory retrieval processes, namely recollection and familiarity. However, fundamental questions remain regarding the functional nature and neural substrates of these processes. In this article, we describe a simple quantitative model of recognition memory (i.e., the dual‐...... hiện toàn bộ
AbstractUnderstanding the empirical rules that regulate alterations of hippocampal firing fields will enhance our understanding of hippocampal function. The current study sought to extend previous research in this area by examining the effect of substituting a new stimulus for a familiar stimulus in a familiar environment. Hippocampal place cells were recorded whil...... hiện toàn bộ
AbstractIn the hippocampus, oscillations in the theta and gamma frequency range occur together and interact in several ways, indicating that they are part of a common functional system. It is argued that these oscillations form a coding scheme that is used in the hippocampus to organize the readout from long‐term memory of the discrete sequence of upcoming places, ...... hiện toàn bộ
AbstractThe sources of ipsilateral projections from the hippocampal formation, the presubiculum, area 29a‐c, and parasubiculum to medial, orbital, and lateral prefrontal cortices were studied with retrograde tracers in 27 rhesus monkeys. Labeled neurons within the hippocampal formation (CA1, CA1′, prosubiculum, and subiculum) were found rostrally, although some wer...... hiện toàn bộ
AbstractNumerous studies have reported a smaller hippocampal volume in Alzheimer's disease (AD) patients than in aging controls. However, in mild cognitive impairment (MCI), the results are inconsistent. Moreover, the left‐right asymmetry of the hippocampus receives less research attention. In this article, meta‐analyses are designed to determine the extent of hipp...... hiện toàn bộ