Hippocampal volume and asymmetry in mild cognitive impairment and Alzheimer's disease: Meta‐analyses of MRI studies

Hippocampus - Tập 19 Số 11 - Trang 1055-1064 - 2009
Feng Shi1, Bing Liu1, Yuan Zhou1, Chunshui Yu2, Tianzi Jiang1
1National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China
2Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing, China

Tóm tắt

AbstractNumerous studies have reported a smaller hippocampal volume in Alzheimer's disease (AD) patients than in aging controls. However, in mild cognitive impairment (MCI), the results are inconsistent. Moreover, the left‐right asymmetry of the hippocampus receives less research attention. In this article, meta‐analyses are designed to determine the extent of hippocampal atrophy in MCI and AD, and to evaluate the asymmetry pattern of the hippocampal volume in control, MCI, and AD groups. From 14 studies including 365 MCI patients and 382 controls, significant atrophy is found in both the left [Effect size (ES), 0.92; 95% confidence interval (CI), 0.72–1.11] and right (ES, 0.78; 95% CI, 0.57–0.98) hippocampus, which is lower than that in AD (ES, 1.60, 95% CI, 1.37–1.84, in left; ES, 1.52, 95% CI, 1.31–1.72, in right). Comparing with aging controls, the average volume reduction weighted by sample size is 12.9% and 11.1% in left and right hippocampus in MCI, and 24.2% and 23.1% in left and right hippocampus in AD, respectively. The findings show a bilateral hippocampal volume loss in MCI and the extent of atrophy is less than that in AD. By comparing the left and right hippocampal volume, a consistent left‐less‐than‐right asymmetry pattern is found, but with different extents in control (ES, 0.39), MCI (ES, 0.56), and AD (ES, 0.30) group. © 2009 Wiley‐Liss, Inc.

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Tài liệu tham khảo

10.1080/1360786031000120732

10.1001/archneur.63.5.693

10.1159/000084560

10.1016/j.pscychresns.2006.01.007

10.1001/archpsyc.64.3.297

10.1176/appi.ajp.161.4.598

10.1176/appi.ajp.161.4.598

10.1212/01.WNL.0000149638.45635.FF

10.1016/S1053-8119(02)00026-5

Cohen J, 1988, Statistical power analysis for the behavioral sciences, Lawrence Erlbaum Associates

10.1111/j.1460-9568.2004.03710.x

10.1016/j.neurobiolaging.2005.07.003

10.1212/01.WNL.0000130531.90205.EF

10.1212/WNL.52.6.1158

10.1001/archpsyc.63.1.57

10.1002/(SICI)1098-1063(2000)10:2<136::AID-HIPO2>3.0.CO;2-J

10.1016/j.neurobiolaging.2003.12.007

10.1212/01.wnl.0000256697.20968.d7

10.1016/S0197-4580(01)00271-8

10.1093/brain/awf226

10.1037/1082-989X.1.2.170

10.1007/BF02900302

10.1001/archneur.56.3.281

10.1016/S0022-510X(01)00669-4

10.1093/cercor/bhh174

Hedges LV, 1985, Statistical methods for meta‐analysis

10.1111/j.1600-0404.2006.00540.x

10.1097/YCO.0b013e3280ebb613

10.1002/jmri.10163

10.1212/01.wnl.0000180958.22678.91

Jarvenpaa T, 2004, Hippocampal MRI volumetry in cognitively discordant monozygotic twin pairs, J Neurol Neurosurg Psychiatry, 75, 116

10.1016/j.neurobiolaging.2005.10.010

10.1016/j.neubiorev.2006.03.004

10.1016/j.neulet.2004.02.001

10.1016/S0197-4580(98)00006-2

10.1016/S0028-3932(99)00111-6

10.1016/S0006-3223(99)00167-5

10.3174/ajnr.A0620

10.1212/01.WNL.0000106463.66966.65

Mullen H, 1985, BASIC meta‐analysis: Procedures and programs

10.1016/j.neuroimage.2005.06.029

10.1212/WNL.59.6.867

10.1017/S1355617703930116

10.1016/j.bbr.2006.12.010

10.1016/j.neuroimage.2003.11.011

10.1038/nrn1433

Orwin RG, 1983, A fail‐safe N for effect size in meta‐analysis, J Educ Stat, 8, 157

10.1016/S0197-4580(03)00084-8

10.1001/archneur.56.3.303

10.1016/S1474-4422(06)70550-6

10.4135/9781412984997

10.1037/1082-989X.1.4.331

Sandstrom CK, 2006, Hippocampal atrophy confounds template‐based functional MR imaging measures of hippocampal activation in patients with mild cognitive impairment, AJNR Am J Neuroradiol, 27, 1622

10.1016/j.neurobiolaging.2003.08.002

10.1016/j.neurobiolaging.2005.09.012

10.1212/01.wnl.0000260698.46517.8f

10.1016/j.neuroimage.2006.12.036

10.1212/01.WNL.0000079053.77227.14

10.1212/01.WNL.0000160089.43264.1A

10.1007/s00415-006-0120-4

10.1002/ana.410300410

10.1002/hipo.20492

10.1038/nrn1009

10.1212/01.wnl.0000194240.47892.4d

10.1136/jnnp.2005.075341

10.1176/appi.ajp.161.11.1957

10.1016/S1053-8119(03)00361-6

10.1016/j.neuroimage.2005.09.017

10.1016/j.neurobiolaging.2005.10.002

10.1016/S0197-4580(00)00238-4

10.1016/j.neurobiolaging.2003.08.006

10.1017/S1041610206004303

10.1002/ana.20503

10.1212/01.wnl.0000250326.77323.01

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Hippocampus

Tập 19 Số 11

1055-1064

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