London taxi drivers and bus drivers: A structural MRI and neuropsychological analysis

Hippocampus - Tập 16 Số 12 - Trang 1091-1101 - 2006
Eleanor A. Maguire1, Katherine Woollett, Hugo J. Spiers
1Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, United Kingdom. [email protected]

Tóm tắt

AbstractLicensed London taxi drivers show that humans have a remarkable capacity to acquire and use knowledge of a large complex city to navigate within it. Gray matter volume differences in the hippocampus relative to controls have been reported to accompany this expertise. While these gray matter differences could result from using and updating spatial representations, they might instead be influenced by factors such as self‐motion, driving experience, and stress. We examined the contribution of these factors by comparing London taxi drivers with London bus drivers, who were matched for driving experience and levels of stress, but differed in that they follow a constrained set of routes. We found that compared with bus drivers, taxi drivers had greater gray matter volume in mid‐posterior hippocampi and less volume in anterior hippocampi. Furthermore, years of navigation experience correlated with hippocampal gray matter volume only in taxi drivers, with right posterior gray matter volume increasing and anterior volume decreasing with more navigation experience. This suggests that spatial knowledge, and not stress, driving, or self‐motion, is associated with the pattern of hippocampal gray matter volume in taxi drivers. We then tested for functional differences between the groups and found that the ability to acquire new visuo‐spatial information was worse in taxi drivers than in bus drivers. We speculate that a complex spatial representation, which facilitates expert navigation and is associated with greater posterior hippocampal gray matter volume, might come at a cost to new spatial memories and gray matter volume in the anterior hippocampus. © 2006 Wiley‐Liss, Inc.

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Tài liệu tham khảo

10.1016/j.neuroimage.2005.02.018

10.1016/j.neubiorev.2004.03.004

10.1073/pnas.91.23.11217

10.1073/pnas.121034798

10.1016/S0028-3932(97)00161-9

10.1016/S0896-6273(02)00830-9

10.1523/JNEUROSCI.20-06-j0005.2000

10.2307/2136404

10.1152/jn.1998.80.2.1002

10.1002/mrm.10050

10.1016/j.neuroimage.2003.09.062

10.1038/427311a

Duvernoy HM., 2005, The Human Hippocampus: Functional Anatomy, Vascularisation and Serial Sections with MRI, 10.1007/b138576

10.1126/science.2740902

10.1196/annals.1284.062

10.1097/00001756-199702100-00032

10.1002/hipo.20193

10.1038/73980

10.1016/S0896-6273(03)00095-3

10.1523/JNEUROSCI.18-17-07027.1998

10.1523/JNEUROSCI.23-13-05945.2003

10.1523/JNEUROSCI.14-12-07347.1994

10.1523/JNEUROSCI.1103-05.2005

10.1016/S0531-5131(03)00997-X

10.1097/00001756-199805110-00076

10.1002/(SICI)1098-1063(1998)8:4<313::AID-HIPO1>3.0.CO;2-I

Lezak MD., 2004, Neuropsychological assessment

10.1093/arclin/5.1.1

10.1038/271

10.1016/0028-3932(96)00022-X

10.1126/science.280.5365.921

10.1073/pnas.070039597

10.1002/hipo.10087

10.1111/j.1749-6632.2001.tb05830.x

10.1002/hup.266

10.1016/S1043-2760(98)00122-2

10.1038/431757a

10.2174/1573405054038726

Meyers JE, 1995, Rey Complex Figure Tests and Recognition Trial

10.1523/JNEUROSCI.13-09-03916.1993

10.1038/nrn843

10.1001/archpsyc.56.6.527

O'Keefe J, 1978, The Hippocampus as a Cognitive Map

10.1002/hipo.450030307

10.1016/0028-3932(71)90067-4

Osterrieth PA., 1944, Le test de copie d'une figure complexe, Archives de Psychologie, 30, 206

10.1006/nlme.1996.0007

10.1006/nimg.2002.1288

10.1038/86115

10.1016/0028-3932(81)90090-7

10.1002/neu.480270103

Spielberger CD., 1983, State‐Trait Anxiety Inventory for Adults (Form Y)

10.1016/j.neuroimage.2006.01.037

10.1002/hipo.1084

10.1073/pnas.97.9.4414

10.1523/JNEUROSCI.0693-05.2005

10.1136/jnnp.2003.017046

Ugurbil K, 1993, Imaging at high magnetic fields: Initial experiences at 4 T, Magn Reson Q, 9, 259

10.1016/j.neuron.2004.07.009

10.1159/000112985

Warrington EK., 1984, Recognition Memory Test

Weschler D., 1987, Weschsler Memory Scale‐Revised

Weschler D., 1998, Weschler Adult Intelligence Scale‐III UK

Weschler D., 1999, Weschler Abbreviated Scale of Intelligence

10.1006/nlme.2001.4008

10.1523/JNEUROSCI.4705-04.2005

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Hippocampus

Tập 16 Số 12

1091-1101

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