Hippocampus

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Inhibition dominates in shaping spontaneous CA3 hippocampal network activities in vitro
Hippocampus - Tập 19 Số 2 - Trang 152-165 - 2009
Ernest C. Y. Ho, Liang Zhang, Frances K. Skinner
AbstractWe have assessed the balance of excitation and inhibition in in vitro rodent hippocampal slices exhibiting spontaneous, basal sharp waves (bSPWs). A defining signature of a network exhibiting bSPWs is the rise and fall in local field activities with frequencies ranging from 0.5 to 4.5 Hz. This variation of extracellular local field activities manifests at t...... hiện toàn bộ
Delayed effects of chronic variable stress during peripubertal‐juvenile period on hippocampal morphology and on cognitive and stress axis functions in rats
Hippocampus - Tập 14 Số 5 - Trang 636-648 - 2004
Ceylan Isgor, Mohamed Kabbaj, Huda Akil, Stanley J. Watson
AbstractAnimal studies on the effects of chronic variable stress during the peripubertal‐juvenile period on hippocampal structure and function are lacking. Twenty‐eight‐day‐old Sprague‐Dawley rats were subjected to random, variable physical or social stress regimens for 4 weeks. Hippocampal volume was found to continue to grow in all lamina examined during the tran...... hiện toàn bộ
Gonadal hormone modulation of hippocampal neurogenesis in the adult
Hippocampus - Tập 16 Số 3 - Trang 225-232 - 2006
Liisa A.M. Galea, Mark D. Spritzer, Jennifer M. Barker, Jodi L. Pawluski
AbstractGonadal hormones modulate neurogenesis in the dentate gyrus (DG) of adult rodents in complex ways. Estradiol, the most potent estrogen, initially enhances and subsequently suppresses cell proliferation in the dentate gryus of adult female rodents. Much less is known about how estradiol modulates neurogenesis in the adult male rodent; however, recent evidenc...... hiện toàn bộ
Mapping the electrophysiological and morphological properties of CA1 pyramidal neurons along the longitudinal hippocampal axis
Hippocampus - Tập 26 Số 3 - Trang 341-361 - 2016
Ruchi Malik, Kelly A. Dougherty, Komal Parikh, Connor Byrne, Daniel Johnston
ABSTRACTDifferences in behavioral roles, anatomical connectivity, and gene expression patterns in the dorsal, intermediate, and ventral regions of the hippocampus are well characterized. Relatively fewer studies have, however, focused on comparing the physiological properties of neurons located at different dorsoventral extents of the hippocampus. Recently, we repo...... hiện toàn bộ
Temporal manipulation of transferrin‐receptor‐1‐dependent iron uptake identifies a sensitive period in mouse hippocampal neurodevelopment
Hippocampus - Tập 22 Số 8 - Trang 1691-1702 - 2012
Stephanie J.B. Fretham, Erik S. Carlson, J. D. Wobken, Philippe Tran, Anna Petryk, M.K. Georgieff
AbstractIron is a necessary substrate for neuronal function throughout the lifespan, but particularly during development. Early life iron deficiency (ID) in humans (late gestation through 2–3 yr) results in persistent cognitive and behavioral abnormalities despite iron repletion. Animal models of early life ID generated using maternal dietary iron restriction also ...... hiện toàn bộ
Enrichment rescues contextual discrimination deficit associated with immediate shock
Hippocampus - Tập 25 Số 3 - Trang 385-392 - 2015
Gregory D. Clemenson, Star W. Lee, Wei Deng, Vanessa Rodriguez Barrera, Kei Iwamoto, Michael S. Fanselow, Fred H. Gage
Altered mossy fiber distributions in adult Fmr1 (FVB) knockout mice
Hippocampus - Tập 12 Số 1 - Trang 47-54 - 2002
Tammy L. Ivanco, William T. Greenough
AbstractThe fragile‐X mental retardation protein (FMRP) is greatly reduced or absent in individuals with fragile‐X mental retardation syndrome, a common, heritable form of mental retardation. Morphological studies suggest that this protein functions in normal synapse maturation and neuronal plasticity. Examination of human brain autopsy tissue has shown that fragil...... hiện toàn bộ
Discriminating accuracy of medial temporal lobe volumetry and fMRI in mild cognitive impairment
Hippocampus - Tập 19 Số 2 - Trang 166-175 - 2009
Anne M. Jauhiainen, Maija Pihlajamäki, Susanna Tervo, Eini Niskanen, Heikki Tanila, Tuomo Hänninen, Ritva Vanninen, Hilkka Soininen
AbstractWe investigated structural and functional changes in the medial temporal lobe (MTL) using magnetic resonance imaging (MRI) and compared the discriminative power of these measures with neuropsychological testing in mild cognitive impairment (MCI) and Alzheimer's disease (AD). Functional MRI (fMRI) was performed in 21 elderly controls, 14 MCI subjects, and 15...... hiện toàn bộ
The development of hippocampal interneurons in rodents
Hippocampus - Tập 16 Số 12 - Trang 1032-1060 - 2006
Lydia Danglot, Antoine Triller, Serge Marty
AbstractInterneurons are GABAergic neurons responsible for inhibitory activity in the adult hippocampus, thereby controlling the activity of principal excitatory cells through the activation of postsynaptic GABAA receptors. Subgroups of GABAergic neurons innervate specific parts of excitatory neurons. This specificity indicates that particular interneuron subgroups...... hiện toàn bộ
Maturation of the hippocampal formation and amygdala in Macaca mulatta: A volumetric magnetic resonance imaging study
Hippocampus - Tập 20 Số 8 - Trang 922-935 - 2010
Christa Payne, Christopher J. Machado, Nancy G. Bliwise, Jocelyne Bachevalier
AbstractMalformations of the hippocampal formation and amygdala have been implicated in several neurodevelopmental disorders; yet relatively little is known about their normal structural development. The purpose of this study was to characterize the early developmental trajectories of the hippocampus and amygdala in the rhesus macaques (Macaca mulatta<...... hiện toàn bộ
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