Encoding versus retrieval of spatial memory: Double dissociation between the dentate gyrus and the perforant path inputs into CA3 in the dorsal hippocampus

Hippocampus - Tập 14 Số 1 - Trang 66-76 - 2004
Inah Lee1, Raymond P. Kesner2
1Department of Neurobiology and Anatomy, University of Texas Houston Medical School, Houston, Texas, USA
2Department of Psychology, University of Utah, Salt Lake City, Utah

Tóm tắt

AbstractThe hippocampus is an essential neural structure for spatial memory. Computational models suggest that the CA3 subregion of the hippocampus plays an essential role in encoding and retrieval of spatial memory. The perforant path (PPCA3) and dentate gyrus (DG)‐mediated mossy fibers (MFs) compose major afferent inputs into CA3. A possible functional dissociation between these afferent inputs was attempted using a simple navigation test (i.e., the modified Hebb‐Williams maze). Behavioral testing was combined with electrolytic lesions of PPCA3 or neurotoxic lesions of the DG, to eliminate each afferent input into CA3. Lesions in either afferent input into CA3 affected learning of an effective navigational path on the maze. The contributions of the two CA3 afferent inputs, however, were different regarding encoding and retrieval of memory measured based on indices operationally defined for the behavioral paradigm (i.e., encoding, the number of errors reduced within a day; retrieval, the number of errors reduced between days). The DG‐lesioned animals exhibited deficits regarding the encoding index, but not the retrieval index, whereas the PPCA3‐lesioned rats displayed deficits regarding the retrieval index, but not the encoding index. The results suggest that the two major afferent inputs of CA3 may contribute differentially to encoding and retrieval of spatial memory. © 2004 Wiley‐Liss, Inc.

Từ khóa


Tài liệu tham khảo

Amaral DG, 1994, The rat nervous system, 443

10.1016/0031-9384(89)90170-4

10.1016/S0166-4328(98)00144-2

10.1002/hipo.1077

10.1037/0735-7044.111.1.225

10.1002/(SICI)1098-1063(1996)6:6<567::AID-HIPO2>3.0.CO;2-E

10.1038/nn887

10.1046/j.1460-9568.1998.00087.x

10.1006/nlme.1999.3931

Lee I, 2001, Selective lesions of the perforant path in CA3 disrupt both encoding and retrieval of spatial memory. Program 315.5, Soc Neurosci Abs, 27

10.1002/(SICI)1097-0185(19990901)256:1<29::AID-AR5>3.0.CO;2-X

10.1002/cne.903390204

10.1037/0033-295X.102.3.419

10.1016/0166-2236(87)90011-7

10.1098/rstb.2001.0945

10.1523/JNEUROSCI.18-18-07535.1998

10.1073/pnas.92.21.9697

10.1016/0361-9230(90)90278-8

10.1016/0031-9384(75)90210-3

10.1037/h0083542

10.1002/(SICI)1098-1063(1996)6:6<601::AID-HIPO5>3.0.CO;2-J

10.1002/hipo.450020209

10.1002/hipo.450040319

10.1016/0006-8993(86)91246-1

10.1037/0735-7044.104.4.544

10.1002/(SICI)1098-1063(1999)9:6<668::AID-HIPO8>3.0.CO;2-9

Yeckel MF, 1998, Spatial distribution of potentiated synapses in hippocampus: dependence on cellular mechanisms and network properties, J Neurosci, 18, 438, 10.1523/JNEUROSCI.18-01-00438.1998

10.1126/science.2114039

Thông tin
Thông tin xuất bản

Hippocampus

Tập 14 Số 1

66-76

Thông tin tác giả