Bioscience Reports
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Cơ quản chủ quản: Portland Press, Ltd.
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Cell BiologyBiophysicsBiochemistryMolecular Biology
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Các bài báo tiêu biểu
Human mesenchymal stem cells - current trends and future prospective
Tập 35 Số 2 - 2015
Stem cells are cells specialized cell, capable of renewing themselves through
cell division and can differentiate into multi-lineage cells. These cells are
categorized as embryonic stem cells (ESCs), induced pluripotent stem cells
(iPSCs) and adult stem cells. Mesenchymal stem cells (MSCs) are adult stem cells
which can be isolated from human and animal sources. Human MSCs (hMSCs) are the
non-haem...
Apoptosis and apoptotic body: disease message and therapeutic target potentials
Tập 39 Số 1 - 2019
AbstractApoptosis is widely known as programmed cell death eliciting no
inflammatory responses. The intricacy of apoptosis has been a focus of an array
of researches, accumulating a wealth of knowledge which led to not only a better
understanding of the fundamental process, but also potent therapies of diseases.
The classic intrinsic and extrinsic signaling pathways of apoptosis, along with
regula...
Na+, K+-ATPase Isozyme Diversity; Comparative Biochemistry and Physiological Implications of Novel Functional Interactions
Tập 20 Số 2 - Trang 51-91 - 2000
Na+, K+-ATPase is ubiquitously expressed in the plasma membrane ofall animal
cells where it serves as the principal regulator of intracellularion
homeostasis. Na+, K+-ATPase is responsible for generating andmaintaining
transmembrane ionic gradients that are of vital importance forcellular function
and subservient activities such as volume regulation, pHmaintenance, and
generation of action potenti...
Chemical and Biological Parameters as Tools to Evaluate and Improve Heavy Metal Phytoremediation
Tập 20 Số 4 - Trang 239-258 - 2000
In this review, chemical and biological parameters are discussed thatstrongly
influence the speciation of heavy metals, their availability tobiological
systems and, consequently, the possibilities to usebioremediation as a cleanup
tool for heavy metal polluted sites. In orderto assess heavy metal availability,
a need exists for rapid, cost-effectivesystems that reliably predict this
parameter and,...
Generating, Partitioning, Targeting and Functioning of Superoxide in Mitochondria
Tập 17 Số 3 - Trang 259-272 - 1997
Recently, we proposed a hypothetical model of coexistence of “Reactive oxygen
cycle” with Q cycle and H+ cycle in mitochondrial respiratory chain to combine
both processes of univalent electron leak for production of superoxide and of
proton leak across inner mitochondrial membrane. This review presents a more
detailed description of this model and summarizes the supporting experimental
evidence o...
FOXA1: a transcription factor with parallel functions in development and cancer
Tập 32 Số 2 - Trang 113-130 - 2012
When aberrant, factors critical for organ morphogenesis are also commonly
involved in disease progression. FOXA1 (forkhead box A1), also known as HNF3α
(hepatocyte nuclear factor 3α), is required for postnatal survival due to its
essential role in controlling pancreatic and renal function. In addition to
regulating a variety of tissues during embryogenesis and early life, rescue
experiments have r...
Hepcidin: regulation of the master iron regulator
Tập 35 Số 3 - 2015
Iron, an essential nutrient, is required for many diverse biological processes.
The absence of a defined pathway to excrete excess iron makes it essential for
the body to regulate the amount of iron absorbed; a deficiency could lead to
iron deficiency and an excess to iron overload and associated disorders such as
anaemia and haemochromatosis respectively. This regulation is mediated by the
iron-r...
Abdominal obesity and colorectal cancer risk: systematic review and meta-analysis of prospective studies
Tập 37 Số 6 - 2017
The association between abdominal obesity (as measured by waist circumference
(WC) and waist-to-hip ratio (WHR)) and colorectal cancer (CRC) has not been
fully quantified, and the magnitude of CRC risk associated with abdominal
obesity is still unclear. A meta-analysis of prospective studies was performed
to elucidate the CRC risk associated with abdominal obesity. Pubmed and Embase
were searched ...
Gene editing and CRISPR in the clinic: current and future perspectives
Tập 40 Số 4 - 2020
AbstractGenome editing technologies, particularly those based on zinc-finger
nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and
CRISPR (clustered regularly interspaced short palindromic repeat DNA
sequences)/Cas9 are rapidly progressing into clinical trials. Most clinical use
of CRISPR to date has focused on ex vivo gene editing of cells followed by their
re-introducti...
Protein Detection Methods in Proteomics Research
Tập 25 Số 1-2 - Trang 19-32 - 2005
In proteomics research chemical as well as physical methods are used to detect
proteins subsequently to their separation. Physical methods are mostly applied
after chromatography. They are either based on spectroscopy like light
absorption at certain wavelengths or mass determination of peptides and their
fragments with mass spectrometry. Chemical methods are used after
two-dimensional electrophor...