Abdominal obesity and colorectal cancer risk: systematic review and meta-analysis of prospective studies

Bioscience Reports - Tập 37 Số 6 - 2017
Yue Dong1, Jiao Zhou2, Yun Zhu3, Linhai Luo1, Tao He1, Hong Hu1, Hao Liu4, Yingliang Zhang1, Dan Luo5, Shuanglan Xu6, Li-Fen Xu7, Jianping Liu8, Jun Zhang1, Zhaowei Teng7
1Department of General Surgery, The People’s Hospital of Yuxi City, The 6th Affiliated Hospital of Kunming Medical University, Yuxi 653100, China
2Department of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
3Department of Nephrology, The People’s Hospital of Yuxi City, The 6th Affiliated Hospital of Kunming Medical University, Yuxi 653100, China
4Department of General Surgery, The First Affiliated Hospital of Dali Medical University, Dali 671000, China
5Department of Pediatrics, The First Affliated Hospital of Kunming Medical University, Kunming 650032, China
6Department of Respiratory, Yan’an Hospital of Kunming City, Kunming 650032, China
7Department of Orthopedic Surgery, The People’s Hospital of Yuxi City, The 6th Affiliated Hospital of Kunming Medical University, Yuxi 653100, China
8Department of Science and Education, The People’s Hospital of Yuxi City, The 6th Affiliated Hospital of Kunming Medical University, Yuxi 653100, China

Tóm tắt

The association between abdominal obesity (as measured by waist circumference (WC) and waist-to-hip ratio (WHR)) and colorectal cancer (CRC) has not been fully quantified, and the magnitude of CRC risk associated with abdominal obesity is still unclear. A meta-analysis of prospective studies was performed to elucidate the CRC risk associated with abdominal obesity. Pubmed and Embase were searched for studies assessing the association between abdominal obesity and CRC risk. Relative risks (RRs) with 95% confidence intervals (95% CIs) were pooled using random-effects model of meta-analysis. Nineteen prospective cohort studies from eighteen publications were included in this meta-analysis. A total of 12,837 CRC cases were identified among 1,343,560 participants. Greater WC and WHR were significantly associated with increased risk of total colorectal cancer (WC: RR 1.42, 95% CI 1.30, 1.55; WHR: RR 1.39, 95% CI 1.25, 1.53), colon cancer (WC: RR 1.53, 95% CI 1.36, 1.72; WHR: 1.39, 95% CI 1.18, 1.63), and rectal cancer (WC: RR 1.20, 95% CI 1.03, 1.39; WHR: RR 1.22, 95% CI 1.05, 1.42). Subgroup analyses further identified the robustness of the association above. No obvious risk of publication bias was observed. In summary, abdominal obesity may play an important role in the development of CRC.

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