Biomedical Chromatography
SCOPUS (1986-1987,1989-2025)SCIE-ISI
1099-0801
0269-3879
Anh Quốc
Cơ quản chủ quản: WILEY , John Wiley and Sons Ltd
Lĩnh vực:
Clinical BiochemistryAnalytical ChemistryBiochemistryDrug DiscoveryMolecular BiologyPharmacologyMedicine (miscellaneous)
Các bài báo tiêu biểu
Rapid screening and identification of α‐glucosidase inhibitors from mulberry leaves using enzyme‐immobilized magnetic beads coupled with HPLC/MS and NMR
Tập 27 Số 2 - Trang 148-155 - 2013
ABSTRACTα‐Glucosidase plays important roles in the digestion and absorption of
carbohydrates in the small intestine. The inhibition of α‐glucosidase is
regarded as a potential way to treat diabetes. We established an approach to
screening α‐glucosidase inhibitors from medicinal plants using enzyme‐coated
magnetic bead. Using 1‐(3‐dimethyl‐aminopropyl)‐3‐ethylcarbodiimide and
N‐hydroxysuccinimide a...
Systematic LC‐MS/MS bioanalytical method development that incorporates plasma phospholipids risk avoidance, usage of incurred sample and well thought‐out chromatography
Tập 24 Số 1 - Trang 2-19 - 2010
AbstractThis treatise summarizes the underlying principle and the road map for
systematic LC‐MS/MS bioanalytical method development. The three themes that have
recently emerged as central to building quality during method
development—phospholipids, incurred sample and sound chromatographic
considerations—are the main focus of this article. In order to reduce the
bioanalytical risk associated with ...
Derivatization reagents in liquid chromatography/electrospray ionization tandem mass spectrometry
Tập 25 Số 1-2 - Trang 1-10 - 2011
AbstractLiquid chromatography/electrospray ionization tandem mass spectrometry
(LC/ESI‐MS/MS) is one of the most prominent analytical techniques owing to its
inherent selectivity and sensitivity. In LC/ESI‐MS/MS, chemical derivatization
is often used to enhance the detection sensitivity. Derivatization improves the
chromatographic separation, and enhances the mass spectrometric ionization
efficien...
Salting‐out assisted liquid/liquid extraction with acetonitrile: a new high throughput sample preparation technique for good laboratory practice bioanalysis using liquid chromatography–mass spectrometry
Tập 23 Số 4 - Trang 419-425 - 2009
AbstractAcetonitrile, an organic solvent miscible with aqueous phase, has seen
thousands of publications in the literature as an efficient deproteinization
reagent. The use of acetonitrile for liquid–liquid extraction (LLE), however,
has seen very limited application due to its miscibility with aqueous phase. The
interest in LLE with acetonitrile has been pursued and reported in the
literature by ...
Enantioseparation of some clinically used drugs by HPLC using cellulose Tris (3,5‐dichlorophenylcarbamate) chiral stationary phase
Tập 17 Số 2-3 - Trang 113-117 - 2003
AbstractThe chiral resolution of some clinically used drugs namely metoprolol,
teratolol, tolamolol, nebivolol (β‐adrenergic blockers), econazole, miconazole
(anti‐fungal agents), cromakalim (anti‐hypertensive agent) and etodolac
(anti‐inflammatory agent) was achieved on cellulose tris
(3,5‐dichlorophenylcarbamate) chiral stationary phase. The mobile phase used was
2‐propanol at 0.5 mL/min with de...
Simplifying sample preparation using fabric phase sorptive extraction technique for the determination of benzodiazepines in blood serum by high‐performance liquid chromatography
Tập 30 Số 6 - Trang 829-836 - 2016
AbstractFabric phase sorptive extraction (FPSE), a recently introduced novel
sample preparation technology, has been evaluated for the extraction of
benzodiazepines from human blood serum. FPSE utilizes a flexible fabric surface
as the substrate platform for creating sol‐gel hybrid organic‐inorganic sorbent
coatings. FPSE media can be introduced directly into the sample containing the
target analy...
Enantiomeric separation of 2‐arylpropionic acid nonsteroidal anti‐inflammatory drugs by HPLC with hydroxypropyl‐β‐cyclodextrin as chiral mobile phase additive
Tập 24 Số 8 - Trang 799-807 - 2010
AbstractThe enantio‐separations of eight 2‐arylpropionic acid nonsteroidal
anti‐inflammatory drugs (2‐APA NSAIDs) were established using reversed‐phase
high‐performance liquid chromatography with hydroxypropyl‐β‐cyclodextrin
(HP‐β‐CD) as chiral mobile phase additive for studying the stereoselective skin
permeation of suprofen, ketoprofen, naproxen, indoprofen, fenoprofen,
furbiprofen, ibuprofen an...
Structural characterization by chromatographic profiling of the oligosaccharides of human immunodeficiency virus (HIV) recombinant envelope glycoprotein gp120 produced in chinese hamster ovary cells
Tập 2 Số 6 - Trang 260-270 - 1987
AbstractThis report together with the paper by T. Mizuochi, M. W. Spellman, M.
Larkin, J. Solomon, L. J. Basa and T. Feizi (1988) Biochem. J. 254, 599–603
describes the structural elucidation of the N‐linked oligosaccharides of the HIV
envelope glycoprotein, gp120 (cloned from the HTLV‐III B isolate and expressed
as a secreted fusion protein after transfection of Chinese hamster ovary cells),
whic...
Applicability of bioanalysis of multiple analytes in drug discovery and development: review of select case studies including assay development considerations
Tập 20 Số 5 - Trang 383-414 - 2006
Định lượng đồng thời atorvastatin và các chất chuyển hóa hoạt động trong huyết tương người bằng phương pháp sắc ký lỏng-khối phổ kế phối hợp sử dụng rosuvastatin làm chuẩn nội Dịch bởi AI
Tập 20 Số 9 - Trang 924-936 - 2006
Tóm tắtPhương pháp sắc ký lỏng-khối phổ kép (LC-MS/MS) đơn giản, nhạy cảm, chọn
lọc và nhanh chóng đã được phát triển và xác thực để định lượng atorvastatin và
các chất chuyển hóa hoạt động ortho-hydroxyatorvastatin và
para-hydroxyatorvastatin trong huyết tương người sử dụng rosuvastatin làm chuẩn
nội (IS). Sau quá trình chiết xuất lỏng-lỏng đơn giản, các chất phân tích được
tách rời sử dụng pha đ...
#Phương pháp sắc ký lỏng-khối phổ phối hợp #định lượng atorvastatin #chất chuyển hóa <jats:italic>ortho</jats:italic>-hydroxyatorvastatin #<jats:italic>para</jats:italic>-hydroxyatorvastatin #chuẩn nội rosuvastatin #huyết tương người.