Enantioseparation of some clinically used drugs by HPLC using cellulose Tris (3,5‐dichlorophenylcarbamate) chiral stationary phase

Biomedical Chromatography - Tập 17 Số 2-3 - Trang 113-117 - 2003
Imran Ali1, Hassan Y. Aboul‐Enein1
1Pharmaceutical Analysis Laboratory, Biological and Medical Research Department (MBC-03-65), King Faisal Specialist Hospital and Research Center, PO Box 3354, Riyadh-11211, Saudi Arabia

Tóm tắt

AbstractThe chiral resolution of some clinically used drugs namely metoprolol, teratolol, tolamolol, nebivolol (β‐adrenergic blockers), econazole, miconazole (anti‐fungal agents), cromakalim (anti‐hypertensive agent) and etodolac (anti‐inflammatory agent) was achieved on cellulose tris (3,5‐dichlorophenylcarbamate) chiral stationary phase. The mobile phase used was 2‐propanol at 0.5 mL/min with detection at 220 nm. The separation factors (α) of these drugs ranged from 1.24 to 3.90 while the resolution factors were from 1.05 to 5.0. The chiral recognition mechanisms between the racemates and the chiral selector are discussed. Copyright ­© 2003 John Wiley & Sons, Ltd.

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Thông tin xuất bản

Biomedical Chromatography

Tập 17 Số 2-3

113-117

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