HPLC‐ELSD determination of kanamycin B in the presence of kanamycin A in fermentation brothBiomedical Chromatography - Tập 29 Số 3 - Trang 396-401 - 2015
Yong Zhang, Hui‐Min He, Jin Zhang, F Liu, Chao Li, Bing‐Wu Wang, Renzhong Qiao
AbstractA novel method for the direct determination of kanamycin B in the presence of kanamycin A in fermentation broth using high performance liquid chromatography with evaporative light scattering detector (HPLC‐ELSD) was developed. An Agilent Technologies C18 column was utilized, evaporation temperature of 40°C and nitrogen pressure of 3.5 b...... hiện toàn bộ
Quinidine oxidative metabolism. Identification and biosynthesis of quinidine 10,11‐dihydrodiol stereoisomersBiomedical Chromatography - Tập 4 Số 2 - Trang 61-64 - 1990
R. Leroyer, O Varoquaux, Charles Advenier, M Pays
AbstractThe isocratic reversed phase high performance liquid chromatographic method proposed for quinidine metabolic studies facilitates particularly the separation of 10(R) and (S) isomers of quinidine 10,11‐dihydrodiols. The finding of each of these forms following a new synthetic pathway allows us to identify and quantify them in biological fluids. These two iso...... hiện toàn bộ
Development and validation of a HPLC method for quantification of rivastigmine in rat urine and identification of a novel metabolite in urine by LC‐MS/MSBiomedical Chromatography - Tập 25 Số 3 - Trang 353-361 - 2011
Karthik Arumugam, C. Mallikarjuna Rao, Ravindranath Reddy Gilibili, Ramesh Mullangi, Ganesan Subramanian, Sidhartha S. Kar, Averineni Ranjithkumar, Gopal Venkatesh Shavi, N Udupa
AbstractA sensitive, specific and accurate HPLC method for the quantification of rivastigmine (RSM) in rat urine was developed and validated. The method involves the simple liquid–liquid extraction of RSM and pyridostigmine as an internal standard (IS) from rat urine with tertiary methyl butyl ether. The chromatographic separation of RSM and IS was achieved with 20...... hiện toàn bộ
Synthesis and analysis of aminochromes by HPLC‐photodiode array. Adrenochrome evaluation in rat bloodBiomedical Chromatography - Tập 17 Số 1 - Trang 6-13 - 2003
Fernando Remião, Nuno Milhazes, Fernanda Borges, Félix Carvalho, Maria de Lourdes Bastos, Francisco Amado, Pedro Domíngues, A. J. Ferrer‐Correia
AbstractThe catecholamine oxidation process induces cardiotoxicity and neurotoxicity. Catecholamines can oxidize to aminochromes through autoxidation or by enzymatic or non‐enzymatic catalysis. Although some toxic effects seem to be related to the formation of aminochromes there is still scarce information concerning the identification and evaluation of these compo...... hiện toàn bộ
Quantitation of oxcarbazepine and its metabolites in human plasma by micellar electrokinetic chromatographyBiomedical Chromatography - Tập 17 Số 4 - Trang 231-238 - 2003
Vincenzo Pucci, Ernst Kenndler, Maria Augusta Raggi
AbstractA reliable micellar electrokinetic chromatographic method for the determination of oxcarbazepine and its two main metabolites, 10‐hydroxycarbamazepine and 10,11‐trans‐dihydroxy‐10,11‐dihydroxycarbamazepine, in human plasma was developed. The separation and determination of the analytes was achieved using a system consisting of 60 ...... hiện toàn bộ
Simultaneous determination of four antiepileptic drugs in serum by high‐performance liquid chromatographyBiomedical Chromatography - Tập 16 Số 1 - Trang 19-24 - 2002
H. Levert, Pascal Odou, H. Robert
AbstractA high‐performance liquid chromatographic method has been developed for the simultaneous determination of oxcarbazepine, 10‐hydroxycarbamazepine, epoxycarbamazepine, carbamazepine, phenobarbital and phenytoin. After protein precipitation by acetonitrile, the supernatant was analysed on a C18 reversed‐phase HPLC column. Antiepileptic dru...... hiện toàn bộ