Biomedical Chromatography

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HPLC‐Q‐TOF‐MS/MS for analysis of major chemical constituents of Yinchen–Zhizi herb pair extract
Biomedical Chromatography - Tập 28 Số 4 - Trang 475-485 - 2014
Zhiwen Fu, Yun Ling, Zhixiong Li, Mingcang Chen, Zhaolin Sun, Chenggang Huang
ABSTRACTThe Yinchen–Zhizi herb pair (YZHP) consists of Herba Artemisiae Scopariae (Yinchen in Chinese) and Fructus Gardeniae (Zhizi in Chinese), and is mainly used to treat icteric hepatitis, itching skin and eczema. However, the bioactive constituents responsible for the pharmacological effects of YZHP are still unclear to date. In this work, a rapid and sensitive...... hiện toàn bộ
Determination of metformin and other biguanides in forensic whole blood samples by hydrophilic interaction liquid chromatography–electrospray tandem mass spectrometry
Biomedical Chromatography - Tập 26 Số 1 - Trang 1-5 - 2012
Lambert K. Sørensen
ABSTRACTMetformin is an anti‐diabetic drug in the biguanide class which also includes phenformin and buformin. Because of the potential adverse effects of the biguanides, a reliable liquid chromatography–tandem mass spectrometry method using pneumatically assisted electrospray ionization was developed for the quantification of the drugs in both live and post‐mortem...... hiện toàn bộ
HPLC‐ELSD determination of kanamycin B in the presence of kanamycin A in fermentation broth
Biomedical Chromatography - Tập 29 Số 3 - Trang 396-401 - 2015
Yong Zhang, Hui‐Min He, Jin Zhang, F Liu, Chao Li, Bing‐Wu Wang, Renzhong Qiao
AbstractA novel method for the direct determination of kanamycin B in the presence of kanamycin A in fermentation broth using high performance liquid chromatography with evaporative light scattering detector (HPLC‐ELSD) was developed. An Agilent Technologies C18 column was utilized, evaporation temperature of 40°C and nitrogen pressure of 3.5 b...... hiện toàn bộ
Investigation of the interactions between Chrysanthemum morifolium flowers extract and intestinal bacteria from human and rat
Biomedical Chromatography - Tập 30 Số 11 - Trang 1807-1819 - 2016
Jinhua Tao, Jin‐Ao Duan, Yiyun Qian, Dawei Qian, Jianming Guo
AbstractFlos Chrysanthemi, dried flower of Chrysanthemum morifolium Ramat, has drawn much attention recently owing to its potential beneficial health effects for human. Flos Chrysanthemi products are usually taken orally and metabolized by intestinal microflora. However, there ...... hiện toàn bộ
Determination of enantiomeric excess by chiral liquid chromatography without enantiomerically pure starting standards
Biomedical Chromatography - Tập 26 Số 10 - Trang 1241-1246 - 2012
Francisco Sánchez, A. Navas Dı́az, E. Sánchez Torreño, Alfonso Aguilar, Ignacio Medina Lama, Manuel Algarra
ABSTRACTA facile approach for the enantiomeric excess determination of enantiomeric mixtures without the necessity of pure enantiomer standards is presented. Promethazine and trimeprazine commercial nonracemic mixtures were used as cases study to probe the validity of the method. Chromatographic resolutions obtained with a chiral column AGP in reverse phase mode we...... hiện toàn bộ
Định lượng đồng thời atorvastatin và các chất chuyển hóa hoạt động trong huyết tương người bằng phương pháp sắc ký lỏng-khối phổ kế phối hợp sử dụng rosuvastatin làm chuẩn nội Dịch bởi AI
Biomedical Chromatography - Tập 20 Số 9 - Trang 924-936 - 2006
Ramakrishna Nirogi, Vishwottam Kandikere, Manoj K. Shukla, Koteshwara Mudigonda, S. Maurya, Ravikumar Boosi, Y. Anjaneyulu
Tóm tắtPhương pháp sắc ký lỏng-khối phổ kép (LC-MS/MS) đơn giản, nhạy cảm, chọn lọc và nhanh chóng đã được phát triển và xác thực để định lượng atorvastatin và các chất chuyển hóa hoạt động ortho-hydroxyatorvastatin và para-hydroxyatorvastatin trong huyết tương người sử dụng rosuvastatin làm chuẩn nội (IS). Sau ...... hiện toàn bộ
#Phương pháp sắc ký lỏng-khối phổ phối hợp #định lượng atorvastatin #chất chuyển hóa <jats:italic>ortho</jats:italic>-hydroxyatorvastatin #<jats:italic>para</jats:italic>-hydroxyatorvastatin #chuẩn nội rosuvastatin #huyết tương người.
Quinidine oxidative metabolism. Identification and biosynthesis of quinidine 10,11‐dihydrodiol stereoisomers
Biomedical Chromatography - Tập 4 Số 2 - Trang 61-64 - 1990
R. Leroyer, O Varoquaux, Charles Advenier, M Pays
AbstractThe isocratic reversed phase high performance liquid chromatographic method proposed for quinidine metabolic studies facilitates particularly the separation of 10(R) and (S) isomers of quinidine 10,11‐dihydrodiols. The finding of each of these forms following a new synthetic pathway allows us to identify and quantify them in biological fluids. These two iso...... hiện toàn bộ
Structural characterization by chromatographic profiling of the oligosaccharides of human immunodeficiency virus (HIV) recombinant envelope glycoprotein gp120 produced in chinese hamster ovary cells
Biomedical Chromatography - Tập 2 Số 6 - Trang 260-270 - 1987
Tsuguo Mizuochi, Michael W. Spellman, Margot Larkin, Julie C. Solomon, Louisette J. Basa, Ten Feizi
AbstractThis report together with the paper by T. Mizuochi, M. W. Spellman, M. Larkin, J. Solomon, L. J. Basa and T. Feizi (1988) Biochem. J. 254, 599–603 describes the structural elucidation of the N‐linked oligosaccharides of the HIV envelope glycoprotein, gp120 (cloned from the HTLV‐III B isolate and expresse...... hiện toàn bộ
Characterization of maleuric acid derivatives on transgenic human monoclonal antibody due to post‐secretional modifications in goat milk
Biomedical Chromatography - Tập 20 Số 9 - Trang 843-856 - 2006
Ling C. Santora, Keith K. Stanley, Ira S. Krull, Karen M. Grant
AbstractA fully human antibody to tumor necrosis factor‐αwas expressed in the mammary glands of transgenic goats. The goat expressed antibody (gAb) is heterogeneous and has several isoforms due to typical cellular post‐translational modifications. In addition, one post‐secretional modification on gAb was discovered by high‐resolution cati...... hiện toàn bộ
Development and validation of a sensitive and specific LC–MS/MS cocktail assay for CYP450 enzymes: Application to study the effect of catechin on rat hepatic CYP activity
Biomedical Chromatography - Tập 34 Số 3 - 2020
Van Nguyen, Michael J. Espiritu, Fawzy Elbarbry
AbstractA sensitive and specific liquid chromatography tandem mass spectrometric (LC–MS/MS) method that enables the simultaneous quantification of probe substrates and metabolites of cytochrome P450 (CYP) enzymes was developed and validated. These substrates (metabolites)—coumarin (7‐hydroxycoumarin), tolbutamide (4‐hydroxytolbutamide), S...... hiện toàn bộ
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