Biomedical Chromatography

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Determination of metformin and other biguanides in forensic whole blood samples by hydrophilic interaction liquid chromatography–electrospray tandem mass spectrometry
Biomedical Chromatography - Tập 26 Số 1 - Trang 1-5 - 2012
Lambert K. Sørensen
ABSTRACTMetformin is an anti‐diabetic drug in the biguanide class which also includes phenformin and buformin. Because of the potential adverse effects of the biguanides, a reliable liquid chromatography–tandem mass spectrometry method using pneumatically assisted electrospray ionization was developed for the quantification of the drugs in both live and post‐mortem...... hiện toàn bộ
HPLC‐ELSD determination of kanamycin B in the presence of kanamycin A in fermentation broth
Biomedical Chromatography - Tập 29 Số 3 - Trang 396-401 - 2015
Yong Zhang, Hui‐Min He, Jin Zhang, F Liu, Chao Li, Bing‐Wu Wang, Renzhong Qiao
AbstractA novel method for the direct determination of kanamycin B in the presence of kanamycin A in fermentation broth using high performance liquid chromatography with evaporative light scattering detector (HPLC‐ELSD) was developed. An Agilent Technologies C18 column was utilized, evaporation temperature of 40°C and nitrogen pressure of 3.5 b...... hiện toàn bộ
Quinidine oxidative metabolism. Identification and biosynthesis of quinidine 10,11‐dihydrodiol stereoisomers
Biomedical Chromatography - Tập 4 Số 2 - Trang 61-64 - 1990
R. Leroyer, O Varoquaux, Charles Advenier, M Pays
AbstractThe isocratic reversed phase high performance liquid chromatographic method proposed for quinidine metabolic studies facilitates particularly the separation of 10(R) and (S) isomers of quinidine 10,11‐dihydrodiols. The finding of each of these forms following a new synthetic pathway allows us to identify and quantify them in biological fluids. These two iso...... hiện toàn bộ
Structural characterization by chromatographic profiling of the oligosaccharides of human immunodeficiency virus (HIV) recombinant envelope glycoprotein gp120 produced in chinese hamster ovary cells
Biomedical Chromatography - Tập 2 Số 6 - Trang 260-270 - 1987
Tsuguo Mizuochi, Michael W. Spellman, Margot Larkin, Julie C. Solomon, Louisette J. Basa, Ten Feizi
AbstractThis report together with the paper by T. Mizuochi, M. W. Spellman, M. Larkin, J. Solomon, L. J. Basa and T. Feizi (1988) Biochem. J. 254, 599–603 describes the structural elucidation of the N‐linked oligosaccharides of the HIV envelope glycoprotein, gp120 (cloned from the HTLV‐III B isolate and expresse...... hiện toàn bộ
Characterization of maleuric acid derivatives on transgenic human monoclonal antibody due to post‐secretional modifications in goat milk
Biomedical Chromatography - Tập 20 Số 9 - Trang 843-856 - 2006
Ling C. Santora, Keith K. Stanley, Ira S. Krull, Karen M. Grant
AbstractA fully human antibody to tumor necrosis factor‐αwas expressed in the mammary glands of transgenic goats. The goat expressed antibody (gAb) is heterogeneous and has several isoforms due to typical cellular post‐translational modifications. In addition, one post‐secretional modification on gAb was discovered by high‐resolution cati...... hiện toàn bộ
Simple and extractionless high‐performance liquid chromatographic determination of rosiglitazone in human plasma and application to pharmacokinetics in humans
Biomedical Chromatography - Tập 18 Số 8 - Trang 613-615 - 2004
Kyoung‐Ah Kim, Ji Young Park
AbstractA simple and extractionless HPLC method using fluorescence detection was developed for the determination of rosiglitazone in human plasma. After deproteinization using perchloric acid the plasma samples were directly injected onto the HPLC system. The mobile phase was composed of acetonitrile (52%) and 20 mm ammonium acetate (48%, pH 7.5),...... hiện toàn bộ
Development and validation of a HPLC method for quantification of rivastigmine in rat urine and identification of a novel metabolite in urine by LC‐MS/MS
Biomedical Chromatography - Tập 25 Số 3 - Trang 353-361 - 2011
Karthik Arumugam, C. Mallikarjuna Rao, Ravindranath Reddy Gilibili, Ramesh Mullangi, Ganesan Subramanian, Sidhartha S. Kar, Averineni Ranjithkumar, Gopal Venkatesh Shavi, N Udupa
AbstractA sensitive, specific and accurate HPLC method for the quantification of rivastigmine (RSM) in rat urine was developed and validated. The method involves the simple liquid–liquid extraction of RSM and pyridostigmine as an internal standard (IS) from rat urine with tertiary methyl butyl ether. The chromatographic separation of RSM and IS was achieved with 20...... hiện toàn bộ
Identification, characterization and quantification of specific neuropeptides in rat spinal cord by liquid chromatography electrospray quadrupole ion trap mass spectrometry
Biomedical Chromatography - Tập 23 Số 9 - Trang 940-950 - 2009
Francis Beaudry, Catherine E. Ferland, Pascal Vachon
AbstractSubstance P and CGRP play a central role in neuropathic pain development and maintenance. Additionally, dynorphin A is an endogenous ligand of opioid receptors implicated in the modulation of neurotransmitters including neuropeptides, such as substance P and CGRP. This manuscript proposes a method to characterize, identify and quantify substance P, CGRP and...... hiện toàn bộ
Synthesis and analysis of aminochromes by HPLC‐photodiode array. Adrenochrome evaluation in rat blood
Biomedical Chromatography - Tập 17 Số 1 - Trang 6-13 - 2003
Fernando Remião, Nuno Milhazes, Fernanda Borges, Félix Carvalho, Maria de Lourdes Bastos, Francisco Amado, Pedro Domíngues, A. J. Ferrer‐Correia
AbstractThe catecholamine oxidation process induces cardiotoxicity and neurotoxicity. Catecholamines can oxidize to aminochromes through autoxidation or by enzymatic or non‐enzymatic catalysis. Although some toxic effects seem to be related to the formation of aminochromes there is still scarce information concerning the identification and evaluation of these compo...... hiện toàn bộ
A high‐performance liquid chromatography assay with a triazole‐bonded column for evaluation of d‐amino acid oxidase activity
Biomedical Chromatography - Tập 30 Số 3 - Trang 384-389 - 2016
Megumi Iwasaki, Yoshiyuki Kashiwaguma, Chihiro Nagashima, Mao Izumi, Ayano Uekusa, Sumiko Iwasa, Mayu Onozato, Hideaki Ichiba, Takeshi Fukushima
AbstractElution profiles of kynurenic acid (KYNA) and 7‐chlorokynurenic acid (Cl‐KYNA) were examined by high‐performance liquid chromatography (HPLC) using a triazole‐bonded stationary phase column (Cosmosil® HILIC) under isocratic elution of a mobile phase consisting of CH3CN–aqueous 10 mm ammonium formate between pH 3.0 and...... hiện toàn bộ
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